查询词典 neuron

Objective To investigate the interrelationship between the expression of VEGF and the oncosis of neuron after ICH by establishing the rat ICH model through the expression of oncosis of neuron after ICH and the cell location of VEGF-positive cells in perihematoma and the expression of VEGF. Methods The rat ICH model was induced by two-step.

目的 通过建立大鼠脑出血动物模型观察血管内皮生长因子在出血灶周的细胞定位和动态表达变化和脑出血后神经细胞胀亡时程表达以探讨两者之间的相关性。

Get the neonate Sprague-Dawley rats medulla spinalis, through the conventional primary cell culture procedure, we use the method of difference adherence time and get the motor neurons of anterior spinal cord. When the neuron is in maturity, we make the mechanical injury model in vitro. All the models were divided into four groups: group A is control group; group B is 100μM ATP group; group C is 100μM ATP+20μg/ml suramin group and group D is 100μM ATP+10μM ouabain+10μg/ml Thapsigargin group. Culture the four groups neurons, after one day, we count the motor neuron, observe the survival and activity of neurons through MTT shade selection experiment, use flow cytometry to analyze the percentage of apoptosis of motor neurons of anterior spinal cord and detect the expression of protein p-GSK-3β(ser9) through Western-Blot technology.

方法取新生大鼠脊髓，通过常规的原代细胞培养程序，采用差速贴壁法分离出大鼠脊髓前角运动神经元，培养成熟后制作神经元机械损伤体外模型，分为A组：对照组、B组：100μMATP组、C组：100gMATP+20μg/ml Suramin组和D组：100μM ATP+IOμM Ouabain+10μg/ml Thapsigargin组，对各组机械损伤的运动神经元进行培养，1天后分别进行运动神经元计数、MTT比色实验观察运动神经元的存活及活性、流式细胞仪分析机械损伤的脊髓前角运动神经元凋亡百分率和Werstern Blot技术检测p-GSK-3β(ser9)的表达。

H reflex recovery curve examimation shows that electric acupuncture can obviously suppress neuron excitability of motor neuron pool in cornu anterius medullae spinalis, decrease accentuatal tension of muscle and Liddell and Sherrington reflex.Conclusions: electric acupuncture can relieve spasm of limbs after cerebral apoplexy.

实验结果说明：针刺阳陵泉缓解脑卒中后肢体偏瘫痉挛状态，可能与针刺刺激提高了中枢神经系统中抑制性氨基酸递质受体的表达，使受体数量增加、敏感性提高，从而提高了抑制性神经递质的效率，使下位中枢运动神经元兴奋性受到抑制有关。

The amount of neuron at 2st week for EG and CC were 36.50±1.78/EF and 19.70±3.71/EF respectively, with the percentage of (43.60±4.83)% and (39.04±3.87)% for EG and CG, which had significant difference (P.05) Conclusion: Self-assembled IKVAV peptide nanofibers, which can degrade the neuron mortality as well as promote neurite sprouting and growth, is a bioactivity scaffold, it can serve as a superordinary nerve tissue engineering scaffold.

自组装IKVAV多肽纳米支架能降低神经元的死亡率，并诱导轴突的发生和生长，具有支架及生物活性双重作用，可作为神经组织工程支架材料。

ResultsThere was no expression of Caspase-3 in group A. The expression of Caspase-3 in group C was decreased compared with that in group B（P＜0.01. In groups B and C, expansion and vacuolization of mitochondria, swollen neurons and apoptotic bodies appeared, which suggested that WBH could induce neuron injury, and the neuron injury in group C was more severe than that in group B.

结果A组大鼠海马区神经元无Caspase-3表达，B、C两组大鼠海马区神经元有Caspase-3表达，B组较C组Caspase-3表达平均灰度值减小。B、C两组大鼠海马神经元超微结构发生改变、细胞器水肿，部分线粒体空化，内质网稀疏，突触前膜、后膜结构不完整，可见自噬体结构；B组大鼠的神经元超微结构损害较C组轻。

To explain relationship between the effect of CLD on senile Demention and neuron in hippocampal area. The change of natural aging mice's neuron in hippocampal area were studied by applying microscope and transilluminating electric microscope. Results: Comparing with the young control, the old control mice's hippocampus had less small pyramid cells, the nerve cells denaturalizing and their branches reducing in the microscope. Hippocampal nerve cells were degenemiceing, with nucleus membrance crinkling like wave shape were not clear, and chromatin condensing with high electron density, heterochromatin accruing, part cell organs inclosing nucleus, nucleus condensing in the EM.

为了阐明菖龙丹抗老年性痴呆作用与海马区神经元结构的关系，运用光镜和透射电镜观察了菖龙丹对自然衰老小鼠海马区形态的影响，结果显示老年对照组小鼠光镜下海马锥体细胞较青年对照组数量减少，细胞体积变小，神经元变性，分枝减少；电镜下海马神经细胞发生退化改变，核膜皱缩，呈波浪状，膜结构不清晰，核染色质浓缩，电子密度高，异染色质较多，部分胞浆细胞器向细胞核聚集，有的可见细胞核固缩。

Methods: The study was designed to observe SS and influence of serum CD_4~+、CD_8~+、IL-2、IL-6、TNF-α, splenic lymphocyte transformation rate, the expression of SS、SSTR-2 in spinal cord、PAG、NRM and hypothalamus the coexistence of SS and enkephalinergic neuron in back corner of spinal cord, the coexistence of SS and 5-HT neuron in NRM by using methods of behavioral nociceptive threshold test, measure of foot's cubage, flowcytometry, MTT, radioimmunity, HPLC-ECD, immunohistochemistry, laser confocal microscope on FAC-induced hyperalgesia.

以弗氏完全佐剂诱发的炎症痛模型大鼠为研究对象，应用行为学痛阈观察、足跖容积测定、流式细胞检测法、MTT法、放射免疫法、高效液相电化学法、免疫组织化学技术法、激光共聚焦技术等方法，观察SS和电针对痛阈、大鼠CD_4~+、CD_8~+、IL-2、IL-6、TNF-α水平和脾淋巴细胞转化率等指标的影响，以及SS、SSTR-2在脊髓和PAG、NRM及下丘脑部位的表达、在脊髓SS与脑啡肽能神经元的共存现象及在NRM中与5-HT能神经元的共存情况。

GFAP overexpessed but NOS neuron decreased, distorted and pale. The glia in SM-DB complex of ONR hypertrophied, but NOS neuron no degeneration. The increased GFAP immunoreactivity and the morphometric and cytological changes in SM-DB complex astrocytes may reflect a sustained upregulation of cellular activity with the insults of neurons, resulting in hypertrophy of glial perikarya and cell processes.

老年减退组星形胶质细胞的细胞体密度较老年正常组和青年组明显增加（P 在GFAP免疫细胞化学和NOS组织化学双重染色的切片上，老年减退大鼠SM-DB星形胶质细胞明显肥大，突起粗壮弯曲，GFAP超量表达，而NOS阳性神经元数量减少，胞体变形，突起减少，染色深度下降。

On the other hand, previously differentiated neuron and astrocyte may also re-express nestin, which may indicate the recovery and plasticity of neuron and astrocyte.

另一方面，已分化的神经元和星形胶质细胞再表达胚胎期蛋白nestin，可能有利于神经元和星形胶质细胞修复。

Based on the return map and the principle of closed vectors, a new method is proposed to extract unstable periodic orbits embedded in chaotic attractors. As examples, the UPOs embedded in chaotic attractors of Logistic, Hénon and Lorenz are extracted respectively by this method. And our results of Skewed Hénon map also be compared with Nusse's. These results suggest that this method is valid for unstable periodic orbits from period one to period infinite of arbitrary dimension chaotic system. The dynamic considerations of spiking and UPO coding for individual neuron and neural system under external periodic and chaotic exciting stimulus also be studied in this dissertation. A lot of spiking phenomena, such as synchronization, period, and chaos appear alternatively with the changing of the stimulus frequency. For the small stimulus frequency the neuron could completely convey the periodic signal in synchronous anti-phase into interspike intervals sequences. For the slow time–scale chaotic input, the output two ISI sequences are reciprocally related to input signals, and their oscillation wave shape in time course can be derived from that of the input signals variation, furthermore, the similar input sequence and order of UPOs, distribution of LES and value of KYD remain in attractors reconstructed from ISI sequences.

发现周期信号在单个神经元传递过程中，随着激励频率的改变，神经元输出的峰峰间期interspike interval时间序列呈现出周期、混沌和准周期的交错变化，特别当外加激励信号频率较低时，周期信号可以通过神经元ISI序列以反相同步的周期运动形式传递下去；同时无论是周期还是混沌激励信号，在神经系统中的传递均与其自身强度和神经元之间的耦合强度的大小密切相关；快变时间尺度的混沌激励信号在耦合的神经系统传递过程中，会造成大量基本信息的丢失；而慢变时间尺度的混沌激励信号在神经系统传递中，它的非线性特征信息，如混沌吸引子、不稳定周期轨道、Lyapunov指数谱和分形维数，会通过系统输出的ISI序列部分地重现出来，如与输入慢变时间尺度的混沌激励信号相比，神经系统输出的ISI序列具有：相似几何形状的混沌吸引子、相近的Lyapunov指数谱和分形维数、局部结构相同的不稳定周期轨道的排列方式。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。