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Objective To explore the effects of N -Has gene over expression on malignantly transformed human bronchial epithelial cell induced by anti-benzo pyrene-trans-7,8 dihydrodiol-9,10-epoxide (16HBE-T) using small hairpin RNA. Methods The recombinant plasmid pGPU6/GFP/Neo-NRas-566 including N-Has shHNA was transfected to 16HBE-T cells.

目的 用小发卡RNA(small hairpin RNA, shRNA)干扰技术沉默N-Ras基因表达,探讨N-Ras基因表达对二羟环氧苯并花转化人支气管上皮细胞(16HBE-T)恶性性状的影响。

This dissertation is relation to SrO(La2/3Sr1/3MnO3)n the manganese oxides with RP structure. We mostly studied the structure and electrical transport properties, The major studies are listed below: The classes of magnetoresistance were introduced, the electron and crystal structure and the mechanism of double exchange of manganite pervosike related to colossal magnetoresistance have been summarized. More attention had also been paid to the advance in the study of RP structure manganite and grain system. The principle and process of sol-gel method were introduced. With sol-gel method a series of different grain size La2/3Sr1/3MnO3 sample were prepared.

本文以Mn3+:Mn4+=2:1的Ruddlesden-Popper结构锰氧化物SrO(La2/3Sr1/3MnO3)n为研究对象,系统的研究了利用溶胶-凝胶法制备的n=∞的La2/3Sr1/3MnO3和n=2的La4/3Sr5/3Mn2O7两个系列样品的结构和电磁性质,主要内容包括以下几点:简单介绍了磁电阻效应的分类,概述了具有超大磁电阻效应的锰基钙钛矿氧化物的电子晶体结构和双交换等相关的物理机理,给出RP结构系列锰氧化物的晶体结构和电磁相图以及研究状况,分析了颗粒系统的研究进展。

In order to further understand the relation of structure and function of Tpo, we modify the Tpo gene, using PCR technique to acquire N end domain of Tpo---Tpo〓 and dimmer of N end domain of Tpo---Tpo〓both of them are able to stimulate proliferation of megakaryocyte.

为了进一步了解Tpo结构与功能的关系,获得新型Tpo重组产品,我们对Tpo基因进行了改造,得到了具有Tpo刺激活性的Tpo N端结构域及两个N端结构域构成的双体。

The results showed that the decomposition of 4-nitroimidazole began with the split of the C—NO2 bond in the temperature range of 185—210℃. The strongly oxidative product NO2 destroyed the instable annulus of 4-nitroimidazole instantly, all the other C=N, C=C, C—H and N—H bonds of the five membered ring were broken simultaneously, and the detected gas products of 4-nitroimidazole decomposition were NO2, CO2 and CO.

结果表明,4-硝基咪唑的催化热分解起始于其分子中C-NO2化学键的断裂,温度范围是185~210℃。C-NO2键的强氧化性的裂解产物NO2瞬间作用于4-硝基咪唑分子中不稳定的五员环,使化学键C=N、C=C、C-H和N-H同时被打破。4-硝基咪唑的气体分解产物包括NO2、CO2和CO。

This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物;其中:R 1 为选自基团和的部分;n为整数1或2;R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环;R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素;R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基;R 5 为OH或-OH 8 ;R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基,或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环;R 8 为具有1到12个碳原子的视情况经取代的烷基;或其互变异构体或医药学上可接受的盐。

The influences of N,N'-methene biacrylamide cross-linker,monomer concentration,polymerization time and temperature on swelling ratio were investigated,and reversibility of the hydrogels under various pH conditions at given temperature.

目的通过合成聚丙烯酸-co-α-甲基丙烯酸水凝胶,研究N,N'-亚甲基双丙烯酰胺交联剂、丙烯酸和α-甲基丙烯酸单体浓度、聚合时间对其水凝胶溶胀率的影响,以及温度和不同pH值时水凝胶的pH可逆性。

The optimal conditions were 30 ℃,28.26 lx,2 min,λ40nm, n (AgNO\-3)∶ n=2∶1,dosage of metol 0.5 g/L and dosage of hydroquinone 5 g/L.

适宜条件为 30℃,2 8.2 6lx,2min ,λ 4 0nm ,n(AgNO3 )∶n =2∶1,硫酸对甲胺基苯酚用量为 0 5g/L ,对苯二酚用量为 5g/L。

METHODS Seventy-two patients with intractable depression were randomly assigned into aripiprazole combined with venlafaxine group (studied group, n=36) and venlafaxine alone group (controlled group, n=36). The dose of venlafaxine was 25 mg, bid, for 7-10 d and added to 175-300 mgd^(-1); and that of aripiprazole was 5 mgd^(-1), all together for 6 wk as a course.

将72例难治性抑郁症病人随机分成阿立哌唑合用文拉法辛组(研究组,n=36)与单用文拉法辛组(对照组,n=36),文拉法辛剂量:起始25 mg,bid,7~10 d内加至175~300 mgd^(-1);阿立哌唑剂量:5 mgd^(-1),治疗6 wk。

Then, This HBM method develops the application prospect of the N-SearCut model and improves the practical project value of this model when searching minimal cutset of a graph using this method with N-SearCut model.

将其运用于N-SearCut模型对图的最小割集搜索之中,发展了N-SearCut模型的应用前景,提高了该模型的实际工程价值。

The n-th moment of a distribution is the expected value of the n-th power of the deviations from a fixed value.

分布的n 阶是指偏离固定值的n 次幂的期望值。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口,替代木托盘,免薰蒸,符合欧盟、北美各国对出口货物包装材料的法令要求;喷涂钢托盘适用于重载上货架之用,托盘表面根据需要制作成平板状、波纹状及间隔形式,满足不同的使用要求。

A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。