查询词典 mutations

Objective To investigate the relationship between the two common glucose-6-phosphate dehydrogenase (G6PD) gene mutations in Chinese and their clinical manifestations.

目的 探讨中国人中两种常见葡萄糖-6-磷酸脱氢酶(G6PD)基因突变与临床表现的关系。

However, most mutations are deleterious.

然而，大多数突变是有害的。

Approximately 30% of many populations carry the heightened arousal mutations, while around 60% carry the depressant mutation.

大约30％的人群携带者性欲增高的基因变异，约60％的人携带性欲抑制的基因变异。

In the final chapter, we apply the tubular mutations of the derived category of a derived tubular algebra to Lie algebra.

第五章我们讨论标准代数导出范畴自等价—tubular mutation在李代数中的应用。

In the fourth chapter, using algebraic method, we prove that tubular mutations are auto equivalences of the derived category of a derived tubular algebra, and apply this method to the case of tame concealed algebras, which generalizes a result of Meltzer .

第四章我们用纯代数的方法证明：tubular mutation是tubular型标准代数的导出范畴的自等价，并把该方法应用到tame concealed代数，从而推广Meltzer的结果。

Humanity in the short term to削平hills, rivers diverted, within a hundred years the global forest by 50%, this destructive interference caused by mutations in the environment, causing many species to lose their homes, reduced to the position of extinction, and this the situation is still continuing.

人类能在短期内把山头削平、令河流改道，百年内使全球森林减少50%，这种毁灭性的干预导致的环境突变，导致许多物种失去自己的家，沦落到灭绝的境地，而且这种事态仍在持续着。

Truncation mutations in the adenomatous polyposis coli protein are responsible for familial and sporadic colonic tumours. Except for its function as a role in regulating b-catenin, recent studies show that APC has additional roles in cytoskeletal regulation. It binds to microactin and microtubules directly and indirectly. Furthermore, APC plays an important role in mediating the detraction of chromosome.

编码APC蛋白(adenomatous polyposis coli， APC)基因的缺失突变会导致家族性和散发性的结肠癌，APC蛋白除了能直接参与Wnt信号途径调节b-catenin的浓度之外，最近的研究表明APC蛋白能够与细胞骨架的主要成分微管和微丝直接或间接结合，通过调节微管的解聚和聚合，间接调节染色体的分离，作为潜在的细胞骨架调节分子将细胞骨架与重要的细胞信号转导通路紧密联系在一起。

Rare missense mutations were found in the Dicer and Drosha genes, but their presence or absence did not correlate with the level of expression.

Dicer 和Drosha基因检查却几乎没有发现错配的变异，但是无论出现或不出现变异都与表达水平无关。

Methods Fifty pairs of fresh colorectal cancer and homologous normal tissues were genotyped with Identifiler Kit and the mutations generated in cancer tissues were determined. The mutation rates, the numbers of locus matched without identical allele (A0), 1 identical allele (A1), or 2 identical alleles (A2) and the number of total identical alleles IA(subscript n were calculated. Frequency distributions of A0, A1, A2 and IA were compared among CR-N group, unrelated individual pairs and full sibling pairs. Discrimination functions were established for individual identification from tumor tissues with discriminatory analysis.

用Identifiler系统对50对新鲜结直肠癌组织及其身源正常组织组进行STR分型，计算CR-N组中变异STR基因座及全不同基因座数(A0)、半相同基因座数(A1)、全相同基因座数(A2)和共有等位基因数IA(下标 n，比较CR-N组、无关个体对组和全同胞对组中上述参数的分布差异，通过判别分析建立判别函数。

Conversely, there is also the same amount of evidence that mutations show no epistasis or antagonistic interactions (each additional mutation has a disproportionally small effect).

相反，也有相同数量的证据表明突变没有上位效应，或者是突变没有拮抗的互作（每增加一个突变，只产生小的、不成比例的影响）。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。