查询词典 mutations

Results Mobiligy shifts of SSCP in exon 5 of presenilin-1 was detected in 4 cases with Alzheimer,s disease. Two missense mutation were found in the patients by DNA sequence analyse, one mutation was Leu 130 Met and the other was Vall 57 Leu.Another 11 patients showed one single strend shifted rapidly. But none mobility shifts of SSCP were found in patients with vascular dementia and normal controls. Conclusions It is shown that mutations in exon 5 of presenilin-1 also exist in the patients with sporadic Alzhemer?

结果 发现4名SAD患者的PCR产物SSCP分析发生泳动异常，DNA序列分析发现：这4名SAD患者的130号密码子发生了CTG→ATG错义突变(388位点发生C→A突变)，使编码的氨基酸由亮氨酸变为蛋氨酸(Leu 130 Met)；157号密码子发生了GTG→CTG错义突变(469位点发生G→C突变)，使编码的氨基酸由缬氨酸变为亮氨酸(Val 157 Leu)，另有11名患者SSCP表现为一条单链增快，其性质待定。

Even with the latest DNA sequencing technology, the researchers had to design a special strategy to search for the vanishingly rare mutations.

~* H/ R# l8 L' H 即便是使用最先进的DNA测序技术，研究者们还是要设计专门的策略来寻找正在消失的稀少突变。

Mutations of G-A transition was found in coden 175 of exon 5 of p53 gene in one mutated case of SCC, this resulted in CGC changed to CAC in codon 175 in p53 gene and amino acid change from arginine to histidine in p53 protein.

所有被检的基癌、鳞癌和Bowen病均未见p53基因外显子7突变。

The point mutations of the 12th coden of ras gene and p53 E5 and E7 gene were studied in 40 cases w ith laryngeal squamous cell carcinomas by PCR-SSCP(polymerase chain reaction-s ingle stranded conformational polymorphism).

应用多聚酶链反应-单链构像多态性分析方法分析40例喉鳞状细胞癌H-ras，K-ras，和N-ras基因的第12密码子，p53 基因第5，7外显子中点突变的情况。

"It is now generally conceded by protein chemists that most functional proteins would be difficult to reach or interconvert through a series of successive individual amino acid mutations"Denton, 1985, p.

&现在蛋白质化学家一般都承认，大多数有功能的蛋白质都难以通过一系列连续的不同氨基酸变异而形成或互换&。

Data mutations may be writes or record appends.

数据变动可以是写或记录追加。

Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates［J］.

表2 26例成人白血病患者肿瘤和正常细胞线粒体DNA突变情况

That best form became the next parent, begetting other mutations.

那个最佳形态成为下一个父代，产生其他变体。

That best form became the next parent, begetting other mutations.

那个最佳形态成为下一个父代，带来其他变异。

It turns out that pandas have mutations in two copies of a taste gene called T1R1, which encodes a protein that senses the savory taste of meats, cheeses, broths and other high-protein foods.

原来是大熊猫在称之为 T1R1 的味觉基因的两个备份中有突变；T1R1 编码一种感受肉类、奶酪、肉汤和其它高蛋白食品的香喷喷味道的蛋白质。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。