查询词典 mutations

The D-loop region was found to be a hot spot for somatic mutation in mtDNA of the tumors. The results revealed that 45.7 %(16/35) of the HCCs carried somatic mutation in the D-loop region, and the most mutations are homoplasmy.

过去的研究显示：粒线体DNA D-loop 区域是发生体突变的好发点，本论文的结果显示有45.7 %(16/35) HCC含有D-loop 区域体突变且多为同质性。

Thus most mutations show in the phenotype only when they are homozygous.

表型的变化只有在纯合状态才能表现出来。

No homozygous deletions were found in the MTS1 gene,while point mutations were found in 2 of 18 bladder cancers.

研究表明在多种肿瘤细胞中存在着MTS1基因的纯合缺失和点突变［3～7］。

These properties produce robust systems that limit the catastrophic consequences of transposon mobilization, which can result in the accumulation of deleterious mutations, changes in gene expression patterns, and conditions such as gonadal hypotrophy and sterility.

这些属性特征构成了一个限制由转座元件活动所造成的严重后果的系统，从而防止转座子侵袭所带来的突变积累，基因表达谱的改变，以及生殖腺发育不良和不育。

It was very impossible that those mutations of GX epidemic strains of CSFV can cause the incompleted protection of HCLV vaccine.

GXLZ与GXNN和HCLV、Shimen的氨基酸序列对比发现，在E_2基因B、C高变的抗原区，GXLZ、GXNN在710、713、725、孙石静：广西猪瘟流行毒株E。

To investigate the relationship between mutations in exons 12 and 23 of the ABCB4 gene and intrahepatic cholestasis of pregnancy.

摘 目的：探讨ABCB4基因外显子12和23的突变与妊娠期肝内胆汁淤积症发病的关系。

Signal peptide sequence was removed lest it couldnt be recognized by Bacillus subtilis, gene coding for mature peptide was ligated to downstream of sacB signal peptide sequence of pWB980 to form a new ORF and generate pWB980-LipA, gene coding for its chaperone was also amplified and ligated to the downstream of LipA to generate a secretion/expression vector pWB980-LipAB.thechaperone gene was sequenced and analyzed by multiple alignments, resulted showed that there were mutations of nucleotides(1～7) and amino acids (1～2) with the other reported genes.

为了防止枯草芽孢杆菌信号肽酶不能识别脂肪酶的信号肽，切除掉脂肪酶的信号肽编码序列，与枯草芽孢杆菌分泌表达质粒pWB980连接并与质粒上的SacB信号肽构成一个完整的开放式阅读框，获得重组质粒pWB980-LipA，因为该脂肪酶的活性表达需要一个特异性分子伴侣帮助折叠成有活性的构象，将脂肪酶分子伴侣基因串连到脂肪酶基因的下游，获得重组分泌表达载体pWB980-LipAB并且测序分析分子伴侣的基因序列和氨基酸序列并与其它报导的序列进行了比对，发现有1到7个碱基的差异和1到2个氨基酸残基的突变。

Calyciforus in Donghu Lake. The reproductive pattern of parthenogenesis provides the species cloning matrilineally, and keeping the most parental mutations.

东湖作为一个中型湖泊，其环境条件的季节变化是可以预测的，因此萼花臂尾轮虫休眠卵的产生是有一定规律的。

RESULTS: The common MELAS mutations were not found in this case, but a 276-bp deletion was detected in the mitochondrial DNA between 3 314 bp and 3 589 bp.

结果：患者不存在能引起MELAS的较常见的突变，但在线粒体3314～3589之间有276 bp的碱基缺失。

Our bodies accumulate lipofuscin and oxygen free-radical damage and random DNA mutations and numerous other microcellular problems.

我们的身体不断遭受着褐脂质，氧游基的损害以及偶然的 DNA 突变和其它细胞问题的折磨。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。