查询词典 mutations

Objective: To ascertain the feasibility of detecting p53 gene mutations for early diagnosis of lung cancer using the samples from fibroptic bronchoscopic examination.

摘 要：目的：探讨纤支镜检查标本的p53基因突变检测用于肺癌早期诊断的可行性。

Lower doses lead to cells that have repaired themselves incorrectly and which may be at increased risk of developing cancerously owing to these mutations.

较低剂量导致细胞修复了自己的错误，并可能在风险增加发展中国家的cancerously由于这些基因突变。

We are seeing mutations. Cannibalistic hunger. Typical human behavior is now entirely absent.

我们看见了变化，那是一种只有人肉才能制止的饥渴，典型的人类行为现在完全没有了。

Dr. Cardona said she anticipates mutations in the virus.

Cardona博士表示，她预期病毒会突变。

It has been reported that F185K and C280S mutations of HIV1 integrase would improve the enzyme solubility, and the catalytical activity of the enzyme was the same as that of the wildtype enzyme in vitro.

coli中进行整合酶基因表达，SDSPAGE鉴定表达产物，亲和层析纯化蛋白，酶联免疫吸附实验方法测定整合酶的生物学活性。

Low genetic variation has probably resulted from the refugial nature of these populations since the last glaciation rather than from recurrent pollen dispersal between Chilanshan and Alishan populations of these 2 Chamaecyparis species. Two Hinfl restriction site differences were found in the trnV-trnM intergenic spacer between C. formosensis and C. taiwanensis. Fragment length difference as well as point mutations in the petG-trnP intergenic spacer between C. formosensis and C. taiwanensis were also found.

如此低的遗传变异可能是因为现今之红桧与台湾扁柏族群为冰河期存在之大族群的残留小族群，而未必是花粉散播所提供之基因交流极为频繁所造成。trnV-trnM基因间区间序列在红桧与台湾扁柏两者间有两个HinfI之酶切点之差异，在PetG-trnP基因间区间序列也发现台湾扁柏与红桧之间有限制酶片段长度及其他点突变。

The function of the crystallins proteins, the mutations in crystallin genes and associated phenotypes are summarized.

就晶状体蛋白的功能、品状体蛋白基因突变及其导致的先天性白内障表型进行综述。

However, in view of all the bronchoscopic samples, there was no statistically difference between cytopathologic positive results(11.8％) and the incidence of p53 gene mutations(14.1％).

其中以痰的p53突变率最高（27.6％(t=2.0200，P＜0.05)，但活检组织的p53突变率明显低于病理学阳性结果（t=2.3300，P＜0.05），而综合分析所有痰、灌洗、刷检和活检标本的细胞学和病理学阳性率则与p53突变率之间无明显差异。

Results The whole genome of CVB4 jlu06 strain consisted of 7 395 nucleotides encoding 2183 amino acids, which showed high homologies to other CVB4 strains, with the mutations of 10 amino acids. Phylogenetic analysis proved that CVB4 jlu06 strain showed close relationship to HumanCB4 and POLG_CXB4 strains while showed remote relationship to CXB2 strain. Unlike other non-diabetogenic strains, CVB4 jlu06 strain showed common amino acids with diabetogenic strains at 4 sites in 3A region of non-structural protein.

结果 CVB4 jlu06株基因组全长7395个核苷酸，编码2183个氨基酸，与其他CVB4株的同源性较高，且发生了10个氨基酸的变异，与HumanCB4和POLG_CXB4亲缘关系较近，与CXB2亲缘关系较远；CVB4 jlu06株与具有潜在致糖尿病性病毒株，在非结构蛋白3A区4个位点有共同的氨基酸，与非致病毒株不同。

According to the clock that ticks off the increase in diversity of the DNA of a group of animals due to the accumulation of random mutations, this "population bottleneck" occurred at the beginning of the Younger Dryas.

通过统计出这群动物由于随机变异的积累所产生的DNA变异的情况，从而推算出种群变异的时间，发现这种&种群数瓶颈&恰恰发生在新仙女木期的开始阶段。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。