查询词典 mutations

They found mutations in the ALK gene that cause it to be constantly active in helping cells proliferate.

他们发现引起神经母细胞瘤的ALK基因突变一直很活跃这助长了细胞的增生。

They found ALK mutations in 12 percent of 194 tumor samples from children with the aggressive, high-risk form of the disease.

他们在194例患有侵袭性、高危神经母细胞瘤的儿童肿瘤样本中发现，有12%的样本有ALK基因突变。

Genes can occasionally undergo changes, called MUTATIONS, to new allelic forms.

基因也会发生偶然的变异来形成新的等位形式，称之为突变。

Two other missense mutations (G288R and 711D) and a 1944-bp genomic deletion coding for exons 16 to 19 in the FLNA gene were identified in 3 additional, smaller, unrelated families affected by alular dystrophy, which demonstrates the responsibility of FLNA as a cause of XMD.

在另外3个患瓣膜营养不良症非该家族成员中，我们证实有两个编码外显子16和19的基因错义（G288R和711D）和一个基因缺失。这证明FLNA是XMD的致病重要原因。

This testing method can be used for detection of characterized point mutations in β-thalassemia, which is convenient, reliable and economical for prenatal gene diagnosis of β-thalassemia with a broad prospect in aristogenesis.

MASPCR技术适合于检测β-地中海贫血已知点突变类型，是一种简便、可靠、经济的产前基因诊断方法，具有广阔的优生科学应用前景。

Objectives To search for mutations in NOTCH3 gene in four Chinese families with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

方法对 4个经临床和病理检查证实的CADASIL家系中的先证者作NOTCH3基因编码区外显子 1～ 12的聚合酶链反应和DNA测序，对家系 2和 4中的部分亲属也作了同样的检查。

Objective To explore effects of mutations in the tyrosine methionine aspartic acid aspartic acid motif of hepatitis B virus polymerase gene on lamivudine therapy.

目的 探讨乙型肝炎病毒多聚酶酪氨酸蛋氨酸天冬氨酸天冬氨酸基序变异对拉米夫定抗病毒疗效的影响。

To date mutations in 16 autosomal genes have been suggested to be causative of FDCM.

到目前共发现了16个常染色体基因突变与家族性扩张型心肌病相关。

Five missense mutations in the most commonly altered PTP were biochemically examined and found to reduce phosphatase activity.

在人类肿瘤细胞中表达野生型而不是突变型PTPRT可以抑制肿瘤生长。

The Cry1Ac5 domainⅢhas a distant relationship with other Cry1 proteins and its longβ18-β19 loop possesses a unique tryptophanat residue 544 and a unique asparagineat the loop apex(residue 546),as well as two consecutive serinesfrom residue 547 to 548.Alanine scanning mutations within the loop were initially generated and all mutants could produce bipyramidal crystals and express 130 kDa protoxins.

利用Swiss-Model服务器和Swiss-pdb Viewer软件建立了Cry1Ac5蛋白的三维结构模型，并利用Clustal W和DS ViewerPro软件对比分析了其与其它Cry蛋白之间的差异，发现Cry1Ac5的结构域Ⅲ与其它Cry1蛋白的亲缘关系较远，其结构域Ⅲ上的β18-β19 loop比Cry1Aa、Cry2Aa、Cry3Aa和Cry4Aa蛋白对应的loop长，其组成的残基中色氨酸(W544)、连续的丝氨酸(S547、S548)和loop顶点的天冬酰氨(N546)在Cry蛋白中都是独特的残基分子成分。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐