查询词典 mutations

PURPOSE: Acquired somatic uniparental disomy is commonly observed in myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, or secondary acute myelogenous leukemia and may point toward genes harboring mutations.

目的：在骨髓增生异常综合征、骨髓增生异常/骨髓增生新生物或继发性急性髓细胞白血病中常见后天性体细胞单亲二倍体，并且可能涉及基因突变。

Many of the changes caused by these mutations will be unnoticeable; however, by chance a mutation may occur in a gene that produces a phenotypic change.

很多的变化所造成的，这些突变会unnoticeable ，但是，一个偶然的机会， A突变可能发生在一个基因所产生的表型变化。

Here we report frequent somatic mutations in the heterotrimeric G protein alpha-subunit, GNAQ, in blue naevi (83%) and ocular melanoma of the uvea (46%).

我们在此报道了蓝痣(83%)和眼葡萄膜黑素瘤(46%)中异源三聚体G蛋白α亚单位——GNAQ——的屡次突变。

Cardiac hypertrophy is one of adaptive responses of the heart to a variety of pathological stimuli, including hypertension, myocardial infarction, congenital heart disease, heart valvula disease, and perturbations in sarcomeric function due to altered expression or mutations of contractile proteins. Increase in wall tension and hormonal stimuli are thought to directly activate various membrane-bound receptors and signal transduction cascade within cardiomyocytes resulting in the activation of immediate early genes and responsive genes such as c-jun, c-fos, c-myc, egr-1, ANF, BNP. Then the expression of construction proteins such as MLC-1, skeletal α-actin was unregulated.

中文题名hhlim基因的表达调节及其与心肌细胞肥大发生之间的关系副题名外文题名 hhlim gene expression regulation and its role in development of cardiomyocyte hypertrophy 论文作者郑斌导师温进坤韩梅学科专业生物化学与分子生物学研究领域\研究方向学位级别博士学位授予单位河北医科大学学位授予日期2003 论文页码总数106页关键词心肌细胞肥大基因表达心肌肥厚 hhlim基因馆藏号BSLW /2003 /R542.2 /33 心肌细胞肥大是高血压、心脏瓣膜病、急性心肌梗塞及先天性心脏病等临床常见疾病的一种并发症，是心肌细胞对多种病理刺激的一种适应性反应。

In viticulture, a clone refers to a vine variety that is selected for specific qualities which result from natural mutations.

在葡萄栽培领域，一株单体指的是由于自然的突变，而产生的具有特殊品质的葡萄品种。

The statistical analysis of this large set of mutations has led us to propose a diagnostic strategy that should help with the molecular work-up of optic neuropathies.

这一大系列基因突变的统计学分析引导我们提出一个诊断策略，可以帮助我们对视神经病变进行分子学的诊断检查。

Analysis of these mutations and cloning the corresponding loci will shield light on the underlying molecular mechanism in the control of floral asymmetry and facilitate our understanding on the evolution of the zygomorphic development.

对这些突变体的分析和基因克隆有助于阐明两侧对称花型发育的调控机制和理解两侧对称花型的进化途径。

These changes and mutations only have an effect at the point where a new zygote is created.

这些转变只在受精卵产生时才起作用。

Abnet CC, Huppi K, Carrera A, et al. Control region mutations and the' common deletion' are frequent in the mitochcndrial DNA of patients with esophageal squamous cell carcinoma.

肿瘤是多因素、多步骤发展的产物，各种致癌物既然能有效地作用于mtDNA引起其产生与肿瘤相关的遗传改变，那么mtDNA在肿瘤细胞中的生物学意义必将得到重视。

Some gene mutations of rob gene of the 5 E.coli isolates were related to animal species and to the level of drug resistance by affecting on the expression level of AcrAB efflux pump.

不同源性大肠杆菌的rob基因的核苷酸序列与其动物源性有关，该基因的核苷酸序列的个别突变位点可能影响AcrAB外输泵的表达水平，进而影响其多重耐药水平。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。