查询词典 mutationally

Although a few TK genes have been shown to be mutationally altered in specific human cancers (1), it is not known how many or how often members of the TK gene family are altered in any particular cancer type.

尽管有少数TK基因被报道在特定的人类肿瘤中有突变，但对整个TK基因家族中有多少个基因多少次在某一特定肿瘤类型中有突变，还是个未知数。

Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

因而IDH1似乎是作为一种肿瘤抑制因子而存在，一旦通过突变使之灭活，则可能会部分的通过HIF-1α途径参与肿瘤的发生。

Subsequent studies of mutationally altered AMPK activity explained the dominant mode of disease inheritance and the phenotypes of cardiac glycogen accumulation and preexcitation in the conduction system.

随后，PRKAG2突变改变AMPK活性的研究解释了疾病显性遗传的模式、心脏糖原积累及传导系统中预激的表现型。

Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

因而异柠檬酸脱氢酶-1(IDH1)似乎是作为一种肿瘤抑制因子而存在，一旦通过突变使之灭活，则可能会部分的通过缺氧诱导因子亚单位α（HIF-1α）的途径而参与肿瘤的发生。

Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

研究者认为，IDH1具有肿瘤抑制子的作用，一旦IDH1发生突变失活则导致HIF-1通路发生改变促进肿瘤发生。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。