查询词典 mutation

Objective To study the p16 and K-ras mutation in benign and malignant pleural effusions.

目的：探讨p16和K-ras基因在良恶性胸水细胞中的突变情况及对肺癌的诊断作用。

1764 Nucleotide mutations of HBV was identified by cccDNA sequence analysis when detectable, or by PCR of HBV X gene segment spanning the mutation region. Sequence homology analysis was accomplished by using Entrez software.

其中，72例为肝细胞癌，18例为终末期肝硬化，对外科切除和穿刺标本的病理学分析表明这些人群普遍存在慢性活动性肝炎的病理背景。

Helicobacter pylori infection causes the defect of mismatch repair in eucaryotes, and microsatellite instability in gastric epithelial cells, which increases the spontaneous mutation of relative genes, and finally results in the susceptibility to tumors in human bodies.

H pylori 感染导致了真核细胞错配修复(mismatch repair， MMR)系统的缺陷，在胃上皮细胞中引起微卫星不稳定(micrsatellite instable， MSI)，使相关基因自发突变率增加，最终可导致机体对肿瘤的易感。

The possibility of researching gene mutation with the technique of gene chip was discussed. A new imagination to randomly determine DNA sequence in different living beings with the technique of gene chip was advanced. In this way, whether the encoding sequence gene in DNA of eukaryon organism has some regularity was studied.

进而提出新设想——采用基因芯片技术对不同生物群体随机抽样进行DNA测序，从而探讨在真核生物DNA分子链上编码序列遗传基因的变化是否有规则而非随机的，非编码序列遗传基因是否为生物进化过程中曾经有表达能力的结构基因，并分析可能获得的结果。

In the algorithms the tournament selection, partially matched crossover, exchanged mutation and elitist model to evolutes the individuals.

在执行算法操作时，采用联赛选择、部分匹配交叉、交换变异和优值保留相结合的方法来进化取优。

For ADRBK2 gene, systematically mutation screening was performed in all 21 exonic and flanking intronic regions through direct sequencing in 48 schizophrenia probands (including 16 Japanese and 32 Chinese probands) randomly selected from our subjects, and the detected variants and eight SNPs reported in the JSNP database were genotyped in 64 trios.

对于ADRBK2基因，在48名先证者(16名日本人和32名中国人)中进行突变筛查，对ADRBK2的21个外显子的所有序列及外显子与内含子邻接区域的部分内含子进行了测序；同时对突变筛查中发现的错义突变及JSNP数据库中的有关SNP，对64个核心家庭(16个日本人核心家庭，48个中国人核心家庭)的成员进行了基因分型。

For ADRBK2 gene, systematically mutation screening was performed in all 21 exonic and flanking intronic regions through direct sequencing in 48 schizophrenia probands (including 16 Japanese and 32 Chinese probands) randomly selected from our subjects, and the detected variants and eight SNPs reported in the JSNP database were genotyped in 64 trios.

对于ADRBK2基因，在48名先证者(16名日本人和 32名中国人)中进行突变筛查，对ADRBK2的21个外显子的所有序列及外显子与内含子邻接区域的部分内含子进行了测序；同时对突变筛查中发现的错义突变及JSNP数据库中的有关SNP，对64个杨L家庭(16个日本人核心家庭，48个中国人核心家庭)的成员进行了基因分型。

The incidences of mutation of exons 5 to 8 were 17.5%,12.5%,17.5% and 20%,respectively.

结果 40例肺鳞癌组织标本p53基因突变率为67.5%，其中外显子 5～8突变率分别为 17.5%、12.5%、17.5%、20%。

Objective To explore the disease-associated gene mutation of multiple exostoses by family analysis.

目的：经家系分析探索多发性外生性骨疣的相关基因变异。

Molecular genetic testing by targeted mutation analysis for the four common FAH mutations and sequence analysis of the entire coding region are clinically available and can detect mutations in greater than 95% of affected individuals.

分子遗传学检测（对 FAH 的四个常见突变的靶突变分析以及对整个编码区的序列分析）在临床上是可行的，这些检测能检出超过95%的患者中的突变。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。