查询词典 mutation

Beta-thalassemia major is a serious hereditary hemolytic anemia which does great harm to human being.It is a monogenic disease characterised by a reduced synthesis of beta-globin chains,which dues to the Doint mutation or deletion of beta-globin gene and its control region.It not only decreases the hemoglobin level,but breaks the balance of alpha/beta synthesis ratio.The major cellular pathogenetic mechanisms in beta thalassemia are based primarily on the deleterious effects produced by the accumulation of the excess alpha globin chain.These excess alpha-globin chains cannot form stable tetrameric structure and deposit in erythroid cells.They cause large ineffective erythropoiesis on their own,accelerate red cells destruction,and lead to hemolysis.

地中海贫血是一种对人类健康危害严重的遗传性溶血性贫血病，是因β-珠蛋白基因及其调控序列的点突变或缺失致使β-珠蛋白肽链合成减少或完全停止，这不仅使患者血红蛋白水平降低，而且使原来在数量上与之持平的α-珠蛋白肽链相对过剩，这些相对过剩的游离α-珠蛋白肽链并不能形成稳定的四聚体，它们沉积在红细胞中导致了大量无效红细胞生成和红细胞寿命缩短，引起了严重的溶血性贫血。

Increase in plasma tHcy correlates with homozygous mutation of thermolabile MTHFR and decrease in activity of MTHFR. Higher level of folate in the body can interfere the relationship between plasma tHcy and activity of MTHFR.

体内tHcy增高与MTHFR热敏感性基因纯合突变、酶活性下降有关；体内叶酸水平高低影响tHcy与MTHFR酶活性相关性。

The method of mutation breeding and the current research situation of Thiobacillus ferrous oxide are summarized,and some problems in the process of breeding are discussed.

综述了氧化亚铁硫杆菌诱变育种的方法以及诱变育种的研究现状，并对诱变育种过程中的一些问题进行了探讨。

In the past, Tradescantia micronucleu test and tradescantia stamen hair mutation test were used to monitor the pollution of the environment.

以往的研究主要以紫露草微核试验和雄蕊毛突变试验为指标进行环境污染监测。

According to the advance of research of tradescantia ecotoxicology all the world, this paper summarized the advance of research and significance of new problem of Tradescantia micronucleu mechanisms and tradescantia stamen hair mutation mechanisms, and the development of the probe test technology, quantification test technology and tradescantia ecotoxicogenome and so on in order to give a reference to research the tradescantia molecular toxicology.

文章从国内外紫露草生态毒理的研究现状出发，针对紫露草微核产生及雄蕊毛突变机制这类新问题的研究现状及意义，以及探针检测技术、定量检测技术和紫露草的生态毒理基因组学的发展等方面进行综述，为紫露草分子毒理上的研究提供参考。

Operation rules for three kinds of point mutation of DNA sequences (transition, transversion and transformation) are derived.

3推导出DNA序列点突变的运算法则。

The variations consisted of point mutation (transition,transversion and deletion).

变异主要为点突变，包括碱基置换和缺失。

The results of genetic analysis, such as GC content, transition/transversion rate ratios, synonymous substitution rates, indicated that the br fragments with high level of genetic divergence are faced with both purifying selection and bias mutation pressure.

随后的遗传分析，包括GC含量、转换与颠换的比率、同义突变率分析，表明br基因间具有较高的遗传分歧程度，并面临着净化选择和偏倚突变压的双重抑制。

In order to enhance the trehalose production, Y7 was used for mutation with EMS. Through primary screening and compound screening, strain L61 with high-yielding trehalose and deep neutral trehalase activity was screened.

实验对出发菌株Y7进行了EMS诱变处理，通过初筛、复筛，从中选育出一株能高产海藻糖同时具有较低海藻糖分解酶活性的菌株L61。

MtDNA mutation result in insulin deficiency by tricarboxylic acid cycle obstruction.

此外，细胞线粒体的异质性决定其突变的致病效应不同。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。