查询词典 mutation

In vitro, K-ras mutation ASODN could apparently inhibit the growth of Patu 8988 cells （ in a certain degree of dose-dependent and time-dependent manner）,induce apoptosis and decrease the expression of K-ms protein and K-ras mRNA in contrast with SODN, RODN and control groups.

针对K-ras基因第12密码子点突变的反义寡核苷酸可明显抑制人胰腺癌Patu 8988细胞生长，促进细胞凋亡，其机制可能是通过下调K-ras蛋白和K—ras mRNA表达而起作用。

Objective To detect the gene mutation of a family with piebaldism.

目的研究1个斑驳病家系的基因突变情况。

The Cys788Arg mutation may be the main cause of piebaldism in this family.

Cys 788 Arg突变可能为此家系斑驳病的主要原因。

Multiple familial trichoepithelioma is a benign skin tumor related to the pilosebaceous apparatus and inherited in autosomal dominant manner. Attentions have been focused on the mapping and mutation of the disease gene. But the clinical features of MFT are not clearly analyzed in Chinese.

多发性家族性毛发上皮瘤是一种皮肤附属器的良性肿瘤，是常染色体显性遗传性疾病，目前的研究集中在其致病基因的定位及突变上，但对该病的临床分析不够透彻。

The mutation potential of ethephon was by investigated the micronucleus test of bone marrow polychromatophilic erythroblastsPCE cells and sperm shape abnormality test in mice.

为测定乙烯利对人体健康的影响，采用小鼠骨髓细胞微核试验和小鼠精子畸形试验分别检测了乙烯利对小鼠体细胞和生殖细胞的致突变性。

The results indicated that whole H-OLE1 gene could complement fad1 mutation in H. polymorpha recipient lacking △9-fatty acid desaturase. However UFA requirement that Saccharomyces cerevisiae ole1 mutant displays was complemented only by ORF of H-OLE1 driven by S.

发现完整的H-OLE1基因可互补缺乏△9-脂肪酸去饱和酶活性的多形汉逊氏酵母营养缺陷型fad1突变体，却不能互补相应的酿酒酵母ole1突变体，而由酿酒酵母GAP表达框架和H-OLE1 ORF组成的嵌合基因可互补上述ole1突变体。

A single point mutation in intervening sequence 2 (IVS2) of human mitochondrial arginyl-tRNA synthetase gene causes abnormal cleavage of its transcript, resulting in pontocerebellar hypoplasia.

人线粒体精氨酰-tRNA合成酶基因2号内含子中的一个单点突变导致该基因的转录本被异常剪接，造成脑桥小脑发育不全。

We studied the mutation of PDS gene in children diagnosed to have prelingual non-syndromic hearing loss with concomitant bilateral large vestibular aqueduct and Mondini's dysplasia. We tried to find the correlation between non-syndromic hearing loss in local patients and PDS gene, and to establish the basic data of PDS gene mutations in Taiwan.

本篇研究之目的，乃对於患有非症候群学语前听障并合并双侧大前庭导水管及Mondini氏发育异常（Mondini's dysplasia）的儿童，作基因的分析，尝试找出本土非症候群听障与PDS基因的关连性，以建立台湾地区PDS基因突变的基本资料。

We have sequenced the coding region of Cx26 gene from 190 Taiwanese patients with prelingual deafness and 120 unrelated normal individuals. In the deaf patients, three mutations were found: missense mutation, 551G to A and deletion, 235delC and 299-300delAT.

收集120位听力正常人及190位听障孩童对Cx26基因进行多型性比对发现有5种多型性，其中有4种多型性是之前已被发表的：79G→A(V27I)、109G→A(V37I)、341A→G(E114G)及608T→C(I203T)，另发现有一个新的多型性(558G→A)。

Objective Analysis for germline mutation in mismatch repair genes, hMLH1 and hMSH2, in hereditary nonpolyposis colorectal cancer patients and presymptomatic diagnosis in HNPCC families.

目的 通过分析遗传性非息肉性大肠癌患者错配修复基因的遗传性突变，对患者的家族成员进行遗传咨询和症状前的基因诊断。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。