查询词典 mutation

Ten years after diagnosis, 13.6% of the women with a genetic mutation had experienced a recurrence similar to previously found rates for women with nonhereditary cancers treated with BCT.

在明确诊断后的10年，13.6％有基因突变的女性出现肿瘤复发，与以前使用BCT治疗的非遗传性乳腺癌女性相似。

Asked by Medscape Oncolo gy to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said:"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis."

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论，未参与此研究的Franklyn医师表示，这是一个重要的研究，因为它纳入了此一少见甲状腺癌的许多病患，特别是此癌症的偶发或者非遗传变化，且展现出突变与预后有关的可能性；此外，该研究有潜在的临床冲击，但是首先，这些发现需要有其他研究证实重现；这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

Asked by Medscape Oncology to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said: \"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis.\"

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论，未参与此研究的Franklyn医师表示，这是一个重要的研究，因為它纳入了此一少见甲状腺癌的许多病患，特别是此癌症的偶发或者非遗传变化，且展现出突变与预后有关的可能性；此外，该研究有潜在的临床冲击，但是首先，这些发现需要有其他研究证实重现；这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

Over the past two decades, there have been several approximate methods that adopt different mutation models and used for estimating nonsynonymous and synonymous substitution rates based on protein-coding sequences across species or even different evolutionary lineages.

比较基因组分析是研究生物进化关系的基本工具，非同义替换率和同义替换率的计算是研究分子进化动力学的重要内容。在过去的二十多年，基于马尔科夫链的核酸替代模型一直在不断发展。

Results Only unstable random mutations happened in 29 sites with nonsynonymous vs synonymous mutation ratio of 1.42 during 50 passages in 2 serials without maternal antibodies.

LG1株H9N2在没有抗体的鸡胚的传代过程中，仅发生少数碱基的不稳定随机变异，且多为无义突变。

Over the past two decades, there have been several approximate methods that adopt different mutation models and used for estimating nonsynonymous and synonymous substitution rates based on protein-coding sequences across species or even different evolutionary lineages.

近日，中国科学院北京基因组研究所基因组科学及信息重点实验室通过引入新的参数构造模型，发展了一个新的ka/ks算法，该研究成果在近期出版的 Biology Direct 杂志上发表。比较基因组分析是研究生物进化关系的基本工具，非同义替换率和同义替换率的计算是研究分子进化动力学的重要内容。

In coding region of CBF4, SNP frequency is 1 SNP per 96.4 bp, one nonsynonymous mutation was detected from 25 av、203 av and 244 av accessions, which is the 205th site amino acid variation: glynval caused by the 1034th site (corresponding to 19696 site nucleotide of GenBank No.AB015478 as 1) nucleotide variation : GnT.

在编码区，SNP的频率为每96.4 bp一个SNP，其中发现25 av、203 av和244 av 3个生态型CBF4基因区域1034位(以GenBank登录号AB015478序列第19696位的核苷酸为1)碱基变化：GnT，引起第205位氨基酸变化：glynval。

In coding region of CBF4, SNP frequency was 1 SNP per 96.4 bp, one nonsynonymous mutation was detected from 25av, 203av and 244av accessions, which was the 205th site amino acid variation: gly?

在编码区，SNP的频率为每96.4 bp 1个SNP，其中1034位以GenBank No。

Methods Targeting the most common mutation types at codon 526 and codon 531 of Rifampiein Resistance Determining Region of rpoB gene from Mycobacterium tuberculosis ,labeled probes （526CAC, 526TAC, 531TCG and 531TTG） were designed to detect 38 Rifampin-resistant clinical isolates with known RRDR sequence, 24 Rifampin-sensitive clinical isolates with wild type sequence of RRDR and 5 nontuberculous mycobacteria isolates, then a method using real-time PCR was established.

方法针对结核分枝杆菌rpoB基因利福平耐药决定区（Rifampicin Resistance Determining Region，RRDR）526密码子和531密码子常见的突变形式设计探针（526CAC，526TAC，531TCG和531TTG），应用已知rpoB基因RRDR区序列的38株利福平耐药临床分离株和24株利福平敏感临床分离株以及5株非结核分枝杆菌菌株建立荧光定量PCR检测基因突变的方法。

In the second part of this study, skin and muscle fibroblasts were cultured from nine patients with chronic progressive external ophthalmoplegia syndrome for studying the relationship between mtDNA mutation and free radical scavenging enzymes. The skin and muscle fibroblasts from these CPEO patients carried different mtDNA mutations at different levels.

因此，我针对CPEO病人的皮肤和肌纤维母细胞的mtDNA突变和氧化性损伤进行分析，我以南方墨渍法分析皮肤和肌肉纤维母细胞的DNA，发现这9位病人所含的mtDNA突变差异性极大，有4，977 bp、 4，366 bp、 6，190 bp、约10 kb的大片段mtDNA断损突变和粒线体tRNALeu基因的A3243G点突变。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。