查询词典 mutation

By assuming a common mutation rate of the cpDNA-IGS regions, our inferred timings of these events (0.82-4.39 Mya) broadly agrees with both previous geological and molecular estimated time of drainage rearrangements in this region.

基于叶绿体核苷酸平均替代速率，我们推测出了不同分支间的隔离时间大约在0.82-4.39Mya之间，结果与已有的鱼类分子系统的研究结果基本一致，也与现有的地质学文献关于红河改道的时间一致。

MDS is a heterogeneous and common group of clonal hematological disorders characterized by a multi-step process which begins with a somatic mutation in the pluripotential stem cell, and a high rate of tranformation into acute myeloblastic leukemia.

MDS是造血干细胞恶性克隆性疾病，呈现多系改变、多阶段进展两大特征，最终往往发展成AML。

Mutation in the nebulin gene is a disease-causing factor of nemaline myopathies, and this case report presents a specific loss of the nebulin's SH3 domain in the Z-disc.

Nebulin基因突变是细棒状肌病的病因，此病呈现在Z盘nebulin的SH3区域缺损情形。

So far transgenic knockout models of AQP1, AQP3, AQP4 and AQP5, and a knock-in model introducing a point mutation (T126M) that causes autosomal recessive nephrogenic diabetes insipidus in human have been successfully established. Significant progresses have been made in characterizing the physiological functions of these AQPs by systematic mouse phenotype studies.

目前AQP1、3、4、5基因敲除和AQP2基因点突变的基因敲入小鼠模型（模拟人类常染色体隐性遗传尿崩症）已成功建立并广泛用于表型研究，在AQP水通道蛋白生理功能方面获得许多重要进展。

To investigate distribution of gene mutations in LPL exon 9 in Chinese population and to study the possible effects of the mutation on plasma lipids, variants were screened by PCR-SSCP and DNA sequencing. Ser~(447)→stop polymorphism was identified by PCR-RFLP . the plasma lipids in stop447 carrier group and stop447 noncarrier group were compared and analysis.

为探讨中国人群LPL基因外显子9常见突变的种类、频率以及其可能产生的影响，我们利用聚合酶链反应-单链构象多态性分析和DNA测序技术及PCR-RFLP技术检测出我国人群的LPL外显子9基因突变、基因型和等位基因频率，确定了中国人群Ser~(447)→stop这一多态性位点。

It was confirmed that the mutation of nonconservative animo acids in DAF could improve the activities of DAF and the positive charges on the surface of DAF were necessary for its binding with

并证实了DAF分子的非保守性氨基酸突变可提高其活性。

By comparing the amino acids sequences of SCRs of different regulators of complement activation and homologous structure units of DAF in different species, the conservative and nonconservative amino acids in DAF were determined. The possible activity sites were analysed and mutation amino acids sites to construct the mutant library were defined.3. Constructing and evaluating of yeast display mutant library on DAF scaffold.

SCRs多重序列比较及DAF突变位点的选择通过对补体调控蛋白家族成员、不同种属DAF分子的同源结构单位SCR的氨基酸序列进行多重序列比较，确定了DAF分子中的保守性氨基酸和非保守性氨基酸，并根据已有的实验结果，对DAF分子可能活性位点进行了分析，确定了构建酵母细胞表面呈现库的突变氨基酸位点。

Then they examined PTEN in nonhereditary breast tumors from 297 patients and tumors from 34 women who had inherited the BRCA1 mutation.

于是，他们提取297名非遗传性乳腺癌患者和34名有BRCA1 基因变异的遗传性乳腺癌患者的肿瘤细胞进行检查。

Then they examined PTEN in nonhereditary breast tumors from 297 patients and tumors from 34 women who had inherited the BRCA1 mutation.

研究人员检查了297例非遗传性乳腺癌患者肿瘤中PTEN基因，同时也检查了34例具有BRCA1突变的遗传性乳腺癌中的PTEN基因的情况。

Then they examined PTEN in nonhereditary breast tumors from 297 patients and tumors from 34 women who had inherited the BRCA1 mutation. In most cases, the protein that PTEN produces was undetectable in tumor cells, but clearly present in nearby normal cells.

然后他们检查了297名患非遗传性乳房肿瘤的妇女和34名遗传了BRCA1变异并患肿瘤的妇女，发现在大多数情况下，肿瘤细胞里检测不到由PTEN产生的蛋白质，但在附近正常细胞的周围明显存在由PTEN产生的蛋白质。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。