查询词典 mutation

It includes as follows:(1) That the right acceptance probability to decide the initial value temperature should be 0.6 are presented by experiment. For the first time, crossover and mutation operator are used in populations to calculate the initial value of temperature. At least the initial value of temperature is 〓.(2) Replacing random change operator with crossover and mutation operators.

2使用遗传算法中交配与突变代替模拟退火算法中随机扰动操作，对两种操作方法进行定性分析，得到突变和交配操作与随机扰动方法在本质上的一致性；同时首次提出在不同温度条件下，使用不同的比例因子，控制参与交配与突变的基因位数，实现了二次使用模拟退火算法的过程。

Results EROD activities in liver of wild crucian from Zhangtan, Jiangjunyan, Fuyang and Wenyan (23.51±4.17, 16.79±7.39, 18.74±5.16, 18.65±8.86 nmol/) were significantly higher than that of Jiekou (7.84±2.42 nmol/g promin), and no difference was observed between the other sites and Jiekou. Three dose groups (0.25, 0.50, 1.00L/dish water sample extracts) were used in Ames test. Reversional mutation rate of TA98 colony exposed to extracts from Zhangtan was 2.21, 3.39, 6.95 without S9, and 2.70, 4.07, 6.23 with S9, respectively. The revesional mutation of TA100 colony was 2.55, 2.81, 5.36 without S9, and 1.73, 2.86, 4.14 with S9, respectively. Reversional mutation rate of TA98 colony exposed to 1.00L/dish extracts from Jiangjunyan with S9 was 2.22, and there was a dose-response relationship in reversional colony count. Ames tests of the other extracts were negative.

结果 樟潭、将军岩、富阳、闻堰点位野生鲫鱼肝EROD酶活性分别为(23.51±4.17)，(16.79±7.39)，(18.74±5.16)，(18.65±8.86)nmol/，明显高于街口[(7.84±2.42)nmol/]，其他点位与对照比较差异无统计学意义；樟潭水样浓集物在浓度为0.25，0.50，1.00 L/皿时在不加与加S9条件下，TA98回变菌落突变率MR值分别为2.21，3.39，6.95，2.70，4.07，6.23；TA100回变菌落MR值分别为2.55，2.81，5.36，1.73，2.86，4.14；Ames试验结果为明显阳性；将军岩水样浓集物在浓度为1.00 L/皿且加S9条件下TA98MR值为2.22，且在浓度为0.25，0.50，1.00 L/皿加S9条件下TA98回变菌落数呈剂量－反应关系，MR值分别为0.88，1.98，2.22；Ames试验结果为弱阳性；其他点位均为阴性。

All the LOH on 〓 and 〓 was observed in invasive ductal carcino- ma, carcinoma simplex, medulary carcinoma and scirrhous carcino- ma, no deletions at these sites were observed in any invasive lobular carcinoma and others. These results imply an etiological difference.P53 gene is a hot point gene in the occurrence and development of breast, cancer. PCR-SSCP analysis was performed to detect P53 gene point mutation in the region between exon 5 and 8, 5 of 12 (41. 6%) stage I breast cancer patients contain mutation of P53, 3 of 5 patients were accompanied by 〓 deletion. These results suggested that point mutation and allelic loss of P53 gene are two vi- tal genetic events in earlier stage of breast tumorigenesis.

我们还发现，〓和〓位点LOH均分布在乳腺浸润性导管癌、单纯癌、髓样癌及硬癌中，在浸润性小叶癌和某些特殊类型乳腺癌中全部为LOH阴性，上述位点LOH可能与某些组织学类型乳腺癌的发生有关。P53基因是乳腺癌形成过程中的一个热点基因，本研究对12例Ⅰ期乳腺癌组织标本中P53基因热点区域第5、6、7、8外显子点突变进行了测定，发现41.6％（5／12）的病人有P53基因一个或多个点突变，其中3例同时伴有〓位点LOH，表明P53基因点突变和等位基因缺失是发生在乳腺癌形成早期的一个重要遗传学事件。

Lusters of mutations in CP region, a A-to-C mutation at necleotide 1726, a A-to-T mutation at nt 1727 and a C-to-G mutation at nt 1730, were observed in eight of eleven AsCs developing acute exacerbation, Moreover, the clustering mutations were found negative in the state of AsC and positive after acute exacerbation in a subject.

P聚集变异与AsC首次肝炎急性发作有关。 11例中，8例出现CP聚集变异。且 1例在AsC状态时无CP变异，肝炎发作时出现CP聚集变异。(3)CP聚集变异合并CP双变异的乙肝患者，表现为重型肝炎或迅速进展为肝硬化；HBVDNA高水平；HBeAg/抗HBe转换。

The results showed:①Anthocyanin content in mature fruits was 132170 U·g-1FW in bud mutation which was very significantly higher than that in'Ralls'(49140 U·g-1FW);②Activities of PAL and UFGT were almost the same between the two materials, but CH I and DFR activitieswere significantly high in bud mutation, which were related to the increase of anthocyanin levels in the mutant;③Bagging treatment inhibited anthocyanin synthesis of bud mutation. But anthocyanin content had significantly increased after removing the bags. Activities of CHI and UFGT increased rap idly and were much higher than those in the control after the bag removal. The increase was consistentwith the imp rovement of anthocyanin levels.

结果显示：①在果实发育期间，芽变果皮的花青苷含量明显高于'国光'，尤其是成熟期芽变果皮花青苷含量为132170 U·g-1FW，而'国光'仅为49140 U·g-1FW；②在果实发育期间，两个品种间PAL 和UFGT的酶活性无明显差异，但芽变的CHI和DFR酶活性明显高于'国光'，表明芽变花青苷合成能力的提高与CHI和DFR酶活性高有关；③套袋抑制芽变果皮花青苷的合成，但解袋后花青苷的含量极显著升高，解袋后4种酶的变化趋势差异较大， CHI和UFGT活性均迅速升高，明显高于对照，这与解袋后花青苷迅速合成相吻合。

Compared with the exchange and mutation operation in genetic algorithm ,crossover operation becomes helpless when adaptive value of most individules in demes have little difference.The algorithm falls into local solution and can't be solved by exchange. Although mutation can make it shake off local convergence and jump out of local solution, denteric mutation may destroy the produced module that is constructive to form the optimal solution.

相比遗传算法中的交换和变异操作，当种群的多数个体适应值相差不大时交叉操作就显得无能为力，算法陷入局部解而不能由交换解决，突然变异能够使之摆脱局部收敛而跃出局部解，但是后期的变异可能破坏已产生的对形成最优解有建设性作用的模块。

All three exons including splice sites were screened. Results Two of the 25 patients with advanced retinopathy of prematurity showed point mutation in the non-read frame of the third exon of the ND gene. Similar analyses of the first and second non region failed to detect additional mutation, including splice bites. None of the controls resealed similar mutation.

结果 2例患儿的第3外显子的非读码框架基因序列经银染后可见2条异常条带出现，并经直接测序验正发生基因的点突变由T到C，而外显子1及2以及其剪接区均未发现突变对照组未发现相同突变。

Together with the cited sequences of other species (cattle, zebu cattle and buffalo), the molecular phylogenetic tree was therefore built to probe phylogenetic relationship between Bovine subfamilies, Total 5 variation sites were examined and two types of mutation, transition and transversion, were observed, with the overage percentage of nucleotide variation of 1.66%. It demonstrated the poverty of polymorphism at exon 5 of GH gene of three bovine species. There was only one missense mutation out of 5 mutation sites which led to the shift between leu and val amino.

结果表明，在雷琼牛、巴州牦牛和巴州蒙古牛中共检测到5个变异位点，核苷酸取代方式仅有转换和颠换，核苷酸平均突变率仅为1.66%，说明这3个牛种GH基因外显子5多态性较为贫乏；5个变异位点中仅有1个为错义突变，导致亮氨酸和缬氨酸的转换，但该突变在牛种中分布有差异。

3 Was a suitable concentration scope. 4.Mutagenic effect of single-hybrid treated with EMS-mineral oilWhen the pollens of single-cross Xinong No.2 were treated with 0.67 ×10-3 ,white grain mutation and light yellow grain mutation were found in M2 ,and sweet grain mutation , white ear and light yellow ear with steady genetic character were got in Ma.

得到了白粒、浅黄粒突变体；M3出现了甜粒突变体，并得到遗传性状稳定的白色、浅黄色特用玉米果穗。

A frameshift mutation at base position 217 of exon 1 and a T/C missense mutation at base position 59 of exon 3 were found in Yingjing angora rabbit with a high frequency; a T/C same-sense mutation at base position 3 of exon 3 was found with similar frequency in three rabbit breeds.

在外显子1的217位检测到由TCT三碱基插入引起的移码突变，在外显子3的59位和3位分别发生了错义突变由T→C和同义突变由T→C。通过计算发现各位点不同的基因型和等位基因频率在3个兔品种中存在较大的差异，位点A、B在长毛兔和肉兔中均有各自的优势基因型和等位基因。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。