查询词典 mutation

The primary subject of this paper is to (1) The negative-selection algorithm that can be detected abnormity is improved by the mutation mechanism of genetic algorithm.

本文所做的主要工作如下(1)借助遗传算法中变异的机制，对能检测出异常变化的阴性选择算法作了新改进。

But when his group stratified the cohort by mutation status, they observed differences in risk reduction."These results also generate the hypothesis that the protection conferred by risk-reducing salpingo-oophorectomy against specific cancers may differ between carriers of BRCA1 and BRCA2 mutations," Dr. Kauff told attendees."We found that it is highly protective against BRCA -associated gynecologic cancer in both 1- and 2-mutation carriers." And in breast cancer, his team observed a protective effect in BCRA 2 mutations.

当他的团队统计研究对象的突变状态时，他们观察到风险降低的差异性；Kauff医师向与会听众表示，这些结果也产生了藉由风险降低的输卵管卵巢成形术，对特定癌症所提供的保护效果或许会因BRCA1和BRCA2载体突变而有差异的假设；我们发现对这两种载体突变可以高度有效地对抗BRCA有关的妇科癌症；至于乳癌，他的团队观察到在BCRA2突变有保护效果。

But when his group stratified the cohort by mutation status, they observed differences in risk reduction."These results also generate the hypothesis that the protection conferred by risk-reducing salpingo-oophorectomy against specific cancers may differ between carriers of BRCA1 and BRCA2 mutations," Dr. Kauff told attendees."We found that it is highly protective against BRCA -associated gynecologic cancer in both 1- and 2-mutation carriers." And in breast cancer, his team observed a protective effect in BCRA 2 mutations.

当他的团队统计研究对象的突变状态时，他们观察到风险降低的差异性；Kauff医师向与会听众表示，这些结果也产生了藉由风险降低的输卵管卵巢成形术，对特定癌症所提供的保护效果或许会因BRCA1和BRCA2载体突变而有差异的假设；我们发现对这两种载体突变可以高度有效地对抗BRCA有关的妇科癌症；至於乳癌，他的团队观察到在BCRA2突变有保护效果。

The mutation R778L is the most common mutation of ATP7B gene in Chinese WD patients.

经检索2790del3是ATP7B基因新突变类型。R778L是中国人最常见的突变类型。

Patients were divided into two groups, those with gene Arg778Leu mutation in one group and the others in another group. Try to analyse and explore the correlation between gene mutation and clinical manifestation in WD patients.

将检测到该位点有突变和该位点无突变的患者分别归为一组，并与临床资料进行相关分析，探讨该突变点与临床表现型的内在联系。

The method is just like the QuikChange site-directed mutagenesis method except for its special primer. This pair of primers is composed of a long primer and a short primer which is central overlapped.Both of the Tm of 5\'sequence in long primer and Tm of 3\'sequence in short primer are above 66℃.The Tm of short primer is almost half of that of long primer.It is convenient to perform insertion or substitution mutation of DNA fragments larger than 20bp,In addition,it is highly applicable in research about the deletion mutation of DNA fragments larger than 2000bp.

我们实验室一直在寻找一种简单高效的可以用于基因的删除、插入及替代突变的方法，通过大量研究和实验发现，可以使用一种基于反向PCR原理，使用全新的引物设计的突变方法——&COP&突变法，该方法采用与QuikChange点突变法相同的操作步骤，其策略是设计一对中心重合的引物，长引物的5\'端序列和3\'端序列的Tm值均不低于66℃，短引物Tm值约为长引物一半，且与长引物中心重合互补。

Begg argues that all risk factors for breast cancer are overrepresented in incident cases of breast cancer, so that a sample of women who have been diagnosed with breast cancer and who are identified as mutation carriers are more likely to have other breast cancer risk factors than similar mutation carriers who are disease-free.

Dr。 Begg认为，所有的乳腺癌危险因子在乳腺癌病例中都被高估，所以一些已经被诊断为乳腺癌，且确认是某种基因突变的携带者妇女，比起具有相似的遗传突变的健康携带者，更可能是其他乳腺癌的危险因子导致疾病发生。

Begg argues that all risk factors for breast cancer are overrepresented in incident cases of breast cancer, so that a sample of women who have been diagnosed with breast cancer and who are identified as mutation carriers are more likely to have other breast cancer risk factors than similar mutation carriers who are disease-free.

Dr。 Begg认为，所有的乳腺癌危险因子在乳腺癌病例中都被高估，所以一些已经被诊断为乳腺癌，且确认是某种基因突变的携带者妇女，比起具有相似的遗传突变的健康携带者，更可能是其它乳腺癌的危险因子导致疾病发生。

A new mutation that was not inherited from either parent is called a de novo mutation.

一种不是由父母遗传的新突变称为从头突变。

A novel mutation, the P508L mutation, is found in the ALD gene of a Chinese patient with ALD.

发现中国ALD患者一个新的

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。