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Furthermore, abnormal morphology, shrinkage and reduced density of dendritic spines and defects in LTP were observed in brains of the patients suffering from mental retardation and neurodegenerative diseases; many mutant genes found from these patients encode component proteins of signal transduction for neuronal plasticity. These studies on synaptic plasticity would certainly promote making the effective prevention and treatment procedures for mental and neurodegenerative diseases.

此外，在精神迟滞性疾病和神经退行性疾病患者脑内记录到异常的LTP，并发现神经元的树突棘数量减少，形态上产生畸变或萎缩，同时发现，产生突变的基因大多编码调节突触可塑性的信号通路蛋白，故突触可塑性研究也将促进精神和神经疾病的预防和治疗。

The data indicated that Tet was a potent G2 checkpoint abrogator and enhanced the cytotoxicity of X-ray in human p53 mutant breast cancer and colon carcinoma cells.

我们的研究表明，Tet在体外对肿瘤细胞的细胞毒作用较弱，它是一种G2期细胞阻滞清除剂，能显著增加X-射线对人乳腺癌细胞和人结肠癌细胞的杀伤作用。

RESULTS:①A total of 178 injected and survived zygotes were replanted. Thirteen mice were born with the birth rate of 7%.

结果：①178只注射pcDNA3.1-mutant LMNA后的存活受精卵移植至假孕鼠输卵管后，出生13只子代鼠，出生率只有7%；58只注射pcDNA31 -mutant LMNA后的存活受精卵移植到假孕鼠输卵管后，在移植后12~15 d的受体母鼠子宫内收集到1只活胚和5只死胚。

An Escherichia coli library of StEP-derived uricase mutant clones was screened two active and identical mutant uricase genes were obtained.

以筛选具有较原生态尿酸氧化酵素活性为高之变种尿酸氧化酵素。

Due to potential instability of the prophages carrying the stx gene, in this study, the prophage of O157:H7 86-24 strain was cured with serial passages of bacteria, confirmed by PCR and DNA sequencing. The cultural supernatant of O157 prophage curing mutant was inoculated into Vero cells, indicating that the prophage curing mutant of O157 lost the toxigenicity to Vero cells.

由于原噬菌体本身具有潜在的不稳定性，本研究以O157：H7 86-24为始发菌株，将其进行传代培养，筛选原噬菌体消除菌株，对原噬菌体在O157基因组中的整合位点进行分析，并用Vero细胞对原噬菌体消除菌株的细胞毒性进行鉴定。

Low chlorophyll b rice mutant and the wild type rice (Zhenhui 249) were used to study the effects of low chlorophyll b on themiostability of photosystem Ⅱ in mutant by measuring their changes in chlorophyⅡ fluorescence parameters and polyphasic chlorophyⅡ fluorescence transients under different temperature treatments.

通过测定不同温度处理后水稻低叶绿素b突变体及其野生型（镇恢249）叶绿素荧光参数和快速荧光诱导动力学曲线的变化，研究了低叶绿素b对突变体光系统Ⅱ热稳定性的影响。

The VVA0326- mutant carrying a deletion of the GGDEF domain displayed smaller colony morphology on LB plate while compared to the wild type. No difference in colony forming units was found indicating that growth rate is not likely a major factor to confer the phenotype of small colony. In addition, VVA0326- appeared to swim better than wild type bacteria on the swimming plate. VVA0326- grew better, while VVA0328- mutant, which carried a deletion of the EAL domain, grew worse than wild type when the bacteria were cultured on CAS plate at 30°C. This implied that changes in surface structures of the mutants affected the bacterial susceptibilities to HDTMA contained in CAS plate.

缺损了包含一个GGDEF功能区域的突变株 VVA0326-，培养在LB的洋菜胶上，呈现出较小的生长菌落，在测定单位菌落数的结果发现，VVA0326-在生长速度上，相较於野生株并没有不同，因此我们推论生长速率并不是造成菌落变小的主要因子，除此之外，VVA0326-在游泳的分析培养皿中游的比野生株快，在CAS的分析培养皿上，与野生株比较，VVA0326-有比较好的生长状态，而缺损了包含一个EAL功能区域的突变株VVA0328-，却有被抑制生长的现象，可能是因为突变株影响了表面的结构，进而改变了细菌对於HDTMA的敏感层度。

Four further single mutants ofN546(N546G,N546D,N546K,N546Δ), three double mutants and a triple mutant were constructed,and toxins were purified by isoelectric precipitation and an AKTA purifier 100 system.When bioassayed against H.armigera using purified toxins,N546ALC_(501.67μg/mLshowed 1.78 times increased toxicity than wide-type Cry1AcLC_(50 2.98μg/mL,and mutant N546D,N546K and N546Δshowed a great loss in toxicity.

对N546进一步突变，获得了突变子N546G、N546D、N546K和删除突变N546Δ及3个双突变和1个三突变，利用等电点沉淀法和AKTApurifier 100系统纯化了毒素蛋白，生测发现N546ALC_(50为1.67μg/mL对棉铃虫毒力比野生型Cry1AcLC_(50为2.98μg/mL提高了1.78倍，而N546D、N546K和N546Δ的毒力则降低了80～90%。

In order to screen out fine pastures adapted to the east seashores of China,Spartina patens mutant lines induced by low energy heavy ion were grown in a simulating the seashore condition outdoors.A comparison of biomass and photosynthetic ability among 10 mutant lines had been carried out,contents of main organic and inorganic nutritients and main heavy metals in above-ground parts of each line were assayed.

为从经低能重离子诱变的狐米草突变系中筛选出适合在滩涂生长、营养丰富的牧草株系，在前文比较了模拟滩涂环境种植的各突变系生物量和光合能力的基础上，本文进一步检测了几种主要有机和无机营养成分含量以及几种主要重金属污染元素在各突变系地上部分的积累量。

Restriction mechanism for fiber elongation of Lil mutant grown in Held There were abnormities of ultra structure in 9 DPA fibers of Lil mutant whencompared with wild type: thinner cytoplasm, less functional organelles such as Golgi body and endoplasmic reticulum, ect, and more starch grains.

在田间条件下突变体纤维伸长受抑制的原因与野生型比较，突变体开花9d后的纤维细胞在细胞形态学上存在异常：细胞质染色较浅，各种功能性细胞器如高尔基体、内质网等少，有较多的淀粉粒等。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。