查询词典 mutant

Methods Mimicry and speculation on possible displaced amino acids in proper positions of peptide increased the biological effects of TNFR blocking peptide by compote modeling. The original peptide and its mutant were synthesized. The competitively inhibitory effects on green fluorescence protein-tumor necrosis factor fusion protein with TNFR were compared between original peptide and its mutant (receptor competitively inhibitory binding assays). The inhibitory effects on cytotoxicity were compared between original peptide and its mutant.

通过计算机模建，模拟并推测提高TNFR封闭肽生物学效应需置换的位点和氨基酸；合成原封闭肽和突变肽；受体竞争抑制结合实验比较原肽与突变肽对绿色荧光蛋白－肿瘤坏死因子融合蛋白结合TNFR的竞争抑制效应；细胞毒作用抑制实验比较原肽与突变肽对TNFR的封闭效应。

The results are as follows: the dwarf mutant A846 pertain to half-dwarf type, which height is about 38.64 cm on average, preponderating over the half-height of the wild-type, the elongation stage of the mutant represent dwarf character, internode elongation patterns of caulis are similarly the sh-type dwarf mutant, in which the first internode shows specific reduction, the elongation of these cells in the elongation zone immediately above the IM was dissimilar to the wild-type, longitudinal length of parenchyma cells were curtate, also the first internode exhibit markedly, which average is under the corresponding internode of the wild-type, the differentiation of the IM of each internodes of stem was similar to wild-type, as well as the number of internodes and the length of sheath of flag leaf.

结果表明：突变体A846平均株高38.64cm，大于野生型株高的一半，为半矮秆类型；其矮生性在拔节期显著表现；主茎茎秆各节间收缩比例不一，穗下第一节间显著缩短，与sh-型突变体类似；茎秆各节间居间分生组织细胞分化正常，由居间分生组织分化的细胞延伸受到不同程度的阻碍；各节间基本组织细胞纵向长度相应缩短，穗下第一节间缩短比例最大，其平均值小于野生型的一半；主茎节间数目与旗叶的叶鞘长类似于野生型。

It proved that yellow-mutant belongs to the type of absence of chlorophyll; etiolation had relation to the lack of chlorophyll.The biology characteristic of the yellow-mutant cultured in vitro was investigated. The results showed that the mutant behaved etiolation character in different temperature and illumination time condition.

在离体培养条件下，探讨了桑树黄化突变体的生物学特性，发现在不同温度及光照条件下均表现黄化特征，证明该突变体叶色黄化与否与温度变化无关，不属于温敏型或光敏型叶色突变体，但突变体的黄化程度受温度影响而有一定的变化。

Change 6: Mutant Larvae aren't so Mutant After All: Mutant Larvae definitely got kicked in the jaw on this one. They're almost completely useless now. You choose: spend 300 on a new hatchery and have it done for you, or click every ten seconds on your hatchery to produce extra larvae. I'll take the first one, thank you very much. What was once possibly the coolest mechanic the Zerg has now disappeared like Jimmy Hoffa. Maybe we'll find it in the Giants stadium too. Perhaps this nerf was necessary because of the ubiquitous nature of the Queen. In that case… nope, still a bad idea.

变化6：变异幼虫几乎完全无用，你可以选择：使用300水晶来建造一个新的基地为你工作，或是每10秒点击你的基地来或则一个额外的幼虫，而我会选择第一个，这个可能是虫族最酷的一个机制现在也消失了，也许这个削弱在女王可以重复建造后是必须的，但是这仍然是个坏主意，我对这个改变评分C-。

A human promyelocytic leukemia cell mutant (HL-60-AR) with deficiency in HGPRT and resistance to 8-AG was established by treat〓nt of the HL-60 cells with MNNG and prescreened in 0.3% agar RPMI-1640 semisolid medium containing 8-AG. The mutant cells show the following characteristics:(1) resistant to cytotoxic action of 8-AG and growing vigorously in medium containing 20ug/ml 8-AG;(2) capable of forming 〓〓 colonies in soft agar medium in the presenee of 8-AG:(3) highly sensitive to HAT selective medium and fail to growing in HAT medium of form colonies in soft agar medium containing HAT;(4) completely deficinet in HGPRT activity; and (5) no radioactive silver grains over the mutant cells due to the absence of -hypoxanthine incorporation showed by radioautography.

一、用MNNG诱变和8-AG进行抗性筛选，成功地建立了一株抗高浓度8-AG和完全缺失HGPRT活性的人早幼粒白血病细胞突变株(HL-60-AR)，该细胞能抵抗8-AG的毒性作用，对HAT选择培养基十分敏感，检测不到HGHRT活性，不能参入〓H一次黄嘌呤。

Root hairs of wild type were intensely induced in the presence of NAA, while the gls mutant was insensitive to NAA induced root hair initiation; Lateral roots of the wild type were dramatically decreased when treated with 2,4-D, while the gls mutant was insensitive to 2,4-D induced reduction in lateral root initiation; The seminal root length of wild type showed no obvious changes by the treatment with IAA, but the gls mutant was supersensitive to IAA with dramatic reduction in seminal root length, suggesting that the interactions of GLS gene with different hormones may involve different mechanisms.

外源NAA 处理强烈诱导野生型根毛发生，而gls突变体则不敏感；外源2，4-D处理，野生型侧根急剧减少，gls突变体则不敏感；外源IAA处理，野生型种子根长变化不明显，而gls突变体超敏，种子根长迅速变短，表明GLS基因与不同激素有不同的互作机制。

In this study,we focused on the functional analysis of HOXD 13 p.Q317R mutant and polyalanine expansion mutant.PartⅠ:Functional Analysis of the HOXD13 p.Q317R Mutant Associated with Syndactyly TypeⅤHox gene encodes a family of transcription factors of fundamental importance for body patterning during embryonic development.

第一部分HOXD13同源盒p.Q317R点突变的功能分析同源盒基因(homeobox genes，Hox genes)编码一个高度保守的转录因子家族，在决定胚胎期细胞的定向分化与增殖以及调控机体组织器官的发育过程中起关键性作用。

Because homeotic gene mutation and floral organ variation is a direct relationship,therefore the mutant application is the current functional genomics study developmentdirection. We discovered one mutant ah from line 458, which was a line ofthe twin-seedling strain W2555.ln this study, we have investigated the morphogenesisprogress, genetic analysis of mutant traits and molecular tagging of related gene.

目前，由于在水稻中发现的花器官突变体很少，所以对水稻花发育的研究主要是利用双子叶植物MAS-box基因的保守序列设计引物，在水稻基因组或者cDNA文库中筛选与双子叶植物花器官发育相对应的MADS基因，因为同源异型基因的突变与花器官的变异是直接对应的关系，所以突变体的应用是当前功能基因组学的发展方向。

During the first two weeks after birth, the growth performances were not significant between the mutant mice and the normal ones, but after that, the mutant mice grew much slower. The differences were significant in the indexes of eyes, lungs, thymuses, and adrenal glands between the genders. At the same time, the differences were significant in the organ indexes, such as lungs, adrenal glands, uterine and testicles between the normal phenotype mutant mice and the abnormal ones. And these two kinds of mice showed different amount of hemoglobin and red blood cell.

结果：B6-Co小鼠不育率22%、平均产仔数5.62±2.55只、离乳成活率56.59±41.22显著低于正常的B6小鼠，而胎间隔29.50±10.50天比正常B6小鼠短。B6-Co小鼠出生后2周内生长发育与正常B6小鼠基本一致，2周后，其生长发育慢于正常B6小鼠。B6-Co小鼠雌雄间的眼球、肺、胸腺、肾上腺的脏器指数差异有统计学意义。B6-Co表型异常小鼠与B6-Co表型正常小鼠相比，肺、肾上腺、子宫、睾丸的脏器系数差异有统计学意义。B6-Co小鼠表型异常小鼠在血红蛋白和红细胞数量上异于B6-Co表型正常小鼠。

Elegans were significantly decreased after exposure to ENIs（p.05）; also the brood size and the lifespan of C. elegans were significantly reduced after exposure to ENIs（p.05）. Moreover, after exposure to ENIs, the lifespan of mev-1 mutant hermaphrodites was shorter than that of wild type（p.05）, indicating that mev-1 gene mutant could result in more sensitivity of the mutant hermaphrodites to ENIs exposure than the wild type.

结果表明：空气负离子暴露可显著加速野生型和mev-1突变型线虫发育（p.05），缩短寿命（p.05），与野生型相比，空气负离子暴露对mev-1突变线虫寿命影响更大（p.05）；空气负离子暴露可显著降低线虫后代数量（p.05），原因可能在于空气负离子暴露显著诱导性腺细胞凋亡的增加（p.05）。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。