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Objective: To examine the effect of mRNA expression of estrogen receptor and IL-10 in unstimulated peripheral blood mononuclear cells in the pathogenesis of SLE.

目的：探讨未经刺激外周血单个核细胞雌激素受体 mRNA水平和白细胞介素10(IL-10) mRNA水平在系统性红斑狼疮发病中的作用。

Freshly isolated blood mononuclear cells were reversely penetrated by unstimulated human umbilical vein endothelial cells and cultured in medium containing GM-CSF, IL-4 and TNF- a .

此外，本实验还用重组人CEA痘苗病毒转染DC，构建DC疫苗，以求在CEA阳性肿瘤患者的生物治疗上有所突破。

Result Mononuclear cells from C57B/6J mouse bone marrow was stimulated with rmGM-CSF and rmIL-4, with the typical growing pattern of DCs. At the third day, the cells became round or roundlike, semi-adherent clustering just like clusters of grapes. And little mixed cells with long apophyses can been seen.

结果 C57BL/6J小鼠骨髓单个核细胞在rmIL-4和rmGM-CSF刺激下，符合DCs生长的一般规律，即从第3天开始，细胞形态变为圆形或者类圆形，半贴壁，呈&葡萄串&或者呈簇生长；其中还可见到少量长突起的杂细胞。

Methods:Semi-quantitative reverse transcriptase polymerase chain reaction was used to examine the expression of MRP gene in 65 bone marrow aspirates of AL patients and 15 normal volunteers peripheral blood mononuclear cells.

应用半定量逆转录-聚合酶链反应，检测了65例AL患者骨髓和15名正常人外周血单个核细胞中MRP基因的表达。

Methods The peripheral blood mononuclear ceils of healthy adult were induced to form EPCs.

方法诱导健康成人外周血的单个核细胞分化成内皮祖细胞。

Peripheral blood mononuclear cells from this patient were engrafted into NOD/SCID mouse in order to investigate the immune response to donor-type blood group antigens.

该患者的外周血单核细胞被移入NOD/SCID小鼠用于研究对于供者血型抗原的免疫反应。

Objective: Design and synthesize the oligodeoxynucleotides containing unm- ethylated CpG dinucleotides to screen out the optimal CpG-ODN that could markedly enhance the immune function of cord blood mononuclear cells in health newborns. Moreover, observe the action of CpG-1826 (5'-TCCATGACGTTC CTGACGTT-3') as the immune adjuvant of the hepatitis B vaccine on the pregnant mice and their neonatal mice.

目的：设计并合成含非甲基化胞嘧啶和鸟嘌呤二核苷酸的寡聚脱氧核糖核苷酸，以期筛选出对新生儿脐血单个核细胞免疫刺激作用较强的CpG-ODN；观察不同剂量CPG-1826(5'-TCCATGACGTTCCTGACGTT-3')辅助乙肝疫苗免疫孕鼠及仔鼠的作用。

Injection of rhIL-2 (200,100,50,25,12. 5 ku/kg) can inhibit mouse ear swelling, especially when dosage is 25～50 ku/kg. Injection of rhIL-2 (25 ku/kg) can inhibit rat plantar swelling. The function of mononuclear macrophage system was strengthened by hypodermic injection of rhIL-2( 100 ku/kg) once a day for 9 days. The decrease of mouse delayed-type hypersensitivity reaction induced by cyclophosphamide was extenuated by hypodermic injection of rhIL-2(50 ku/kg) once a day for 6 days. IL-2 has anti-inflammatory effects and immunomodulatory effects when administered in certain dosage.

RhIL-2注射液，剂量为20，10，5，2.5，1.25万u/kg时，对小鼠鼠耳肿胀模型有抑制作用，其中剂量为2.5～5万u/kg时，抑制率最大；剂量为2.5万u/kg时，对大鼠足拓肿胀模型有显著的抑制作用；rhIL-2注射液每日sc用药剂量为10万u/kg，连续给药9d后，可以明显增强小鼠单核吞噬细胞功能；rhIL-2注射液每日sc用药剂量为5万u/kg，连续给药6d后，可明显减轻由免疫抑制剂引起的小鼠迟发性变态反应降低的强度。rhIL-2在一定剂量范围内可以起到抗炎和免疫调节作用。

Liposome properties and biological behaviors can be controlled by surface modification. Attachments of hydrophilic polymers, such as poly, enable them to have a prolonged circulation time without being opsonized and recognized by mononuclear phagocytic system.

通过表面修饰可以改变脂质体的性质和生物学行为：在脂质体表面修饰亲水性高分子可以阻碍血浆成分的调理作用，减少脂质体被网状内皮系统识别和摄取，使脂质体具有长循环的特点；在脂质体表面修饰特异性的配基，能使脂质体具有主动靶向的特性。

TB is a kind of the parasitic bacterium and usually parasitizes in its host, mononuclear macrophage once invading the human body. In the infec- ted living body, it is the mycobacterial antigens instead of mycobacterial antibody that emerged in the organism at first.

基于结核分支杆菌是单核巨噬细胞内寄生菌，当感染机体后体内首先出现的是结核抗原，而结核抗原的检出不受宿主免疫状态的影响。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。