查询词典 mitochondria

The full-length Bid is inactive. Cleaved by caspase 8,the carboxy-terminal portion of Bid then translocates to mitochondria and is sufficient to trigger cytochrome c release. This is the key regulatory step in apoptosis.

它具有可被caspase 8酶切调控、高效地诱导细胞色素c从线粒体泄漏到胞浆中的功能，从而在细胞凋亡中起着重要的作用，因而倍受人们的重视。

Upon induction of apoptosis by diverse stimuli, Bax undergoes a conformational change and translocates to mitochondria, where it oligomerizes and forms pores that allow the release of cytochrome c and other cytotoxic foctors.

在被不同刺激诱导后，Bax的构象发生改变并转移到线粒体上。在线粒体膜上，它形成低聚物并使线粒体膜形成孔，使细胞色素c和其它细胞毒性因子可以排出。

However, a steady input of evidence for the transcription-independent function of p53 in apoptosis has been accumulating recently. Although a detailed mechanism has not yet been determined, recent data have revealed that upon an apoptotic stimulus, p53 translocates into mitochondria to interact directly with Bcl-2 or Bcl-xL to displace and activate proapoptotic Bax signaling.

但是，还有研究证明p53也通过转录非依赖的形式来调节细胞凋亡，尽管这个作用的机制还没有被详细的阐明，但是最近的研究报道说明了，p53可以直接转移定位到线粒体上，与Bcl-2或者Bcl-xl结合后，从而使Bax游离下来并活化。

In heathlty cells, AIF protein is normally confined to mitochondrial intermembrane space. However, after apoptosis is induced, AIF protein can be released from mitochondria and translocates into nucleus leading by its nuclear localization signal.

正常情况下，AIF蛋白定位于细胞线粒体膜间隙，当有凋亡信号刺激时，AIF分子从线粒体释放到细胞浆，再通过其核定位信号转位到细胞核中，直接引起染色体凝集和DNA的大片段(~50kb)断裂，导致细胞凋亡。

In order to establish the simple extraction method of wheat mitochondrial DNA, this study investigated the effects of triturating material, exacting mitochondria and exacting and purifying mtDNA from yellow seedling of wheat, respectively.

为了建立小麦线粒体DNA快速提取体系，以小麦黄化苗为材料，分别研究了材料的研磨、线粗体的抽提和mtDNA的提取及纯化过程中众因素的影响。

Results After 3 months of kidney radiation by 15 Gy of Cs137 γ-rays, the changes with kidney shrank, Bowman's capsules straitened or disappeared, glomerular swelled, some epithelia denaturalized or died were observed. Mitochondria tumefied and the cristae shortened, lessened and disordered. Urine β2-MP rose evidently. It was lowered significantly the renal 25-OH-D-1α-hydroxylase activity and its mRNA expression. The dry and ash weight, BMD of femur and lumbar were significantly reduced, volume and width of bone trabecula were distinctly decreased and the space increased in model group. The Pyd / Cr increased and ALP decreased as well.

结果 15Gy 137Cs-γ射线肾局部照射3个月后肾脏体积缩小，肾小球肿大，Bowman氏囊囊腔狭窄甚至消失，部分肾小管上皮细胞变性、坏死，线粒体肿胀，体积增大，线粒体嵴变短、减少、排列紊乱；尿β2-MP显著增加；肾1α羟化酶活性及1α羟化酶mRNA基因表达量明显下降；肾辐射组股骨干重、灰重、腰椎和股骨BMD明显降低；骨小梁体积和骨小梁宽度减少，骨小梁间距增加，MAR减小；腰椎压缩和股骨三点弯最大载荷明显降低，Pyd / Cr值明显增加，ALP显著降低。

It uncouples oxidative phosphorylation but, unlike the aflatoxins, does not induce mitochondrial swelling or hinder Ca2+-induced swelling of mitochondria.

它解开氧化磷酸化但不像黄曲霉毒素类，不能诱导线粒体肿胀或阻止Ca2+诱导的线粒体肿胀。

The result shew, Chromatin broke into pieces which dispersed around the irregular nucleus, nuclear outer member disintegrated; Mitochondria condensed, cristae of which disintegrated partly; The endoplasmic reticulum dilated, vesiculated, gradually disintegrated; A great number of dense granules appeared in the cell. To sum up: Enrichment of heavy metals in Eriocheir sinensis, Macrobrachium nipponease, Cipangopaludina cathayensis is obviou""

综上所述：我们首次证明上海地区沼虾、河蟹、园田螺对重金属元素富集能力要明显强于淡水鱼类；肝、鳃是鱼、虾、蟹体内重金属富集的主要部位；Hg和Cr为高富集元素，Cd是中富集元素，Cu和Pb为低富集元素；罗氏沼虾对镉离子和锌离子的96小时的半致死浓度（LC50）分别为0.115mg/L和0.68mg/L；首次证明锌离子、GSH在一定范围内可以抵抗镉离子对罗氏沼虾肝胰脏破坏。

These results suggest that aloe-emodin induced apoptosis and inhibited invasion in PSC cells were mediated through mitochondria dependent and Ras-MAPK pathways. It implies the possibility that

以上结果说明了芦荟大黄素可能作为一种有效治疗舌咽癌细胞的抗癌药物。

Biological activities of SPThe inhibitory effect of SP on oxidation of lipids and the acitivity of lipoxygenase, the scavenging or quenching effect of SP on free radicals, and the influences of SP on the malonaldehyde content in mice liver juice, liver mitochondria and liver red blood cell were studied. The results showed that SP can inhibit the auto-oxidation of lard and soybean oil at 60 and can inhibit the activity of lipoxygenase significantly; SP also had scavenging effect on hydroxylradicals generated by Fenton system with IC50 value 6.220 mg/ml, under the concentration range of 1 mg/ml-50mg/ml, the scavenging rate of SP to -OH increased strongly when the concentration of SP increased, the maximum scavenging rate was 85.4%.

大豆多肽的生物活性研究研究了大豆多肽抗油脂氧化、抑制脂肪氧合酶及清除自由基的作用，以及对小鼠肝组织匀浆、肝线粒体和红细胞丙二醛含量的影响，结果显示：在60℃时，大豆多肽对猪油与豆油的自动氧化均有一定的抑制作用：对脂肪氧合酶的抑制作用显著：对Fenton体系产生的羟基自由基具有明显的清除作用，其IC_(50)值为6.220mg／ml。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。