查询词典 miracle drug

Distribution of an ionizable drug across a membrane at equilibrium is determined by the drug's pKa （the pH at which concentrations of un-ionized and ionized forms of the drug are equal） and the pH gradient, when present.

一种能解离的药物透过生物膜到达分布平衡取决于药物的pKa（药物的非解离型和解离型浓度相等时的pH）和当时的pH梯度。

Distribution of an ionizable drug acro a membrane at equilibrium is determined by the drug's pKa （the pH at which concentratio of un-ionized and ionized forms of the drug are equal） and the pH gradient, when present.

一种能解离的药物透过生物膜到达分布平衡取决于药物的pKa（药物的非解离型和解离型浓度相等时的pH）和当时的pH梯度。

It showed that drug-resistant genes are important mechanism in which MRSA showed drug resistance of macrocyclic lactones antibacterials;The Panton-Valentine Leukocidin gene in Multiple drug-resistance MRSA were higher than.

多重耐药的MRSA中红霉素耐药基因ermA/B/C检出率较高，是MRSA对大环内酯类抗生素耐药的主要机制；杀白细胞毒素基因PVL检出率较高，是MRSA的重要致病因子。

In this study, we investigate the heat-induced inhibition of drug-metabolizing enzyme activity in mice fed with freeze-dried, heated freeze-dried or half amount autolyzed freeze-dried Brussels sprouts powder. 0.5% ethoxyquin diet was fed to another group of mice as a positive control. The study mice, four per group, were fed a diet consisting of 20% Brussels sprouts for 7 days. Each group had its own pair-fed group. We found significantly greater inductions of glutathione S- transferase, quinine reductase, and phase Ⅱ drug-metabolizing enzyme activities in groups fed within freeze-dried and heated freeze-dried Brussels sprouts than their pair-fed groups. These findings indicate that intestinal microflora still can hydrolyze glucosinolates without plant myrosinase activity, though the alteration of cytochrome- P-450 1A (CYP1A, a phase Ⅰ drug-metabolizing enzyme) induction was only 1.4-fold.

本实验欲进一步探討加热处理之抱子甘蓝对phase Ⅰ与phase Ⅱ解毒酵素活性之影响差异，实验分三组，抱子甘蓝(1)冷冻乾燥组（glucosinolate未裂解）(2)加热冷冻乾燥组(3)半量之裂解冷冻乾燥组（glucosinolate已裂解），(4)and 0.5% ethoxyquin diet was used as a positive control以2%重量混合成饲料，餵以小白鼠（4只／组）7天，结果发现，在第(2)组小白鼠GST phase Ⅱ酵素）活性显著上升，显示在植物裂解酵素不存在之状况下，肠胃道之微生物仍可促进裂解反应，但由CYP1A活性增加不显著（仅1.4倍）看来，根据定义：单独phase Ⅱ酵素活性增加，为monofunctional induction/inducer，可加速致癌物之代谢。

This course mainly includes the basictheories of Drug Toxicology, the toxic effects of drugs and their assessing methods, as well as the application of Drug Toxicology in the nonclinical drug safety evaluation.

本门课程主要包括药物毒理学基础理论，药物的各种毒性作用和评价方法，以及药物非临床安全性评价的毒理学研究内容。

The development of a new kind of radioactive drug includes the research work in its technological process, quality requirements, preclinicopharmacological study and clinical study, The research unit, when designing the technological process for a new drug, muststudy the physical and chemical properties, purity (including pureness of radionuclide), testing method, pharmacology, toxicity, nuclein animal dynamics, radiospecific activity, dosage, pharmaceutical forms and stability of that radioactive drug.

研制单位在制订新药工艺路线的同时，必须研究该药的理化性能、纯度及检验方法、药理、毒理、动物药代动力学、放射性比活度、剂量、剂型、稳定性等。

The sort of new drug of TCM,the declare of new drug of TCM and the manufacture of new drug of TCM(including technics research, establishment of quality standard, pharmic research, toxicology research and clinic research) are introduced systematically.

该课程系统介绍中药新药分类、申报和研制的基本知识、技能，主要内容包括中药新制剂工艺研究、质量标准的制定及稳定性试验、药效学研究、毒理学研究、临床研究。

Both Fas and NO can lead chondrocyte apoptosis respectively and cause articular cartilage destruction. IGF-Ⅰ, TGF-β, bFGF, BMP and other growth factors are polypeptide agents that can influence cell activity by signal convection. They can accelerate chondrocyte proliferation and proteoglycan synthesis, play the local regulation action on formation and plerosis of bone and cartilage tissue by autocrine or paracrine. They have the ability to induce cartilage formation. Some investigations showed that growth factors can influence chondrocyte metabolism, synthesis of specific Ⅱ type collagen and proteoglycan by co-operation and inhibition. 1. 3 Situation of OA therapeutics The therapeutic methods of OA mainly comprised non-drug treatment, drug treatment, operation treatment, tissue and genetic engineering, et al. Drug treatment is the chief method among them.

若其活性发生改变，则将导致关节软骨基质成分的丢失和进行性破坏；软骨细胞凋亡与OA的发病密切相关，Fas与NO可各自独立介导软骨细胞凋亡，造成关节软骨破坏；IGF-Ⅰ、TGF-β、bFGF、BMP等生长因子是一组通过细胞间信号传递影响细胞活动的多肽因子，具有促进细胞生长、增殖与合成等作用，可通过自分泌或旁分泌方式对骨和软骨的形成和修复起局部调节作用，可促进软骨细胞增殖、分化与蛋白多糖的合成，具有较强的诱导软骨形成的能力，研究表明多种生长因子相互促进、相互抑制，以协同或拮抗方式影响软骨细胞代谢，影响软骨细胞特异性Ⅱ型胶原和蛋白多糖的合成分泌。

Methods 230 cases of lacrimal duct obstruction with chronic dacryocystitis divided randomly into two groups.90 cases in group 1 were given operation of laser assisted dacryocytoplasty combining local drug remedy after dashing out the pyoid secretion at once,140 cases in group 2 were not only dashed out the pyoid secretion but also given antibacterial drug, then given operation of laser assisted dacryocytoplasty combining local drug remedy after inflammation was stable. All cases were callback after a week, and followed up more than 6 months.

方法随机选择230名患有慢性泪囊炎泪道阻塞的患者分为两组。1组90名患者冲出脓性分泌物后马上行泪道激光手术联合局部药物治疗，2组140名患者不仅冲出脓性分泌物，且加强抗感染，炎症稳定后再行泪道激光手术联合局部药物治疗，一周后复查，观察两组疗效，追踪半年以上。

Blue and white art blue Calico click here to view all news picture blue Calico prosperity to zhangdongsun'liberty qinhan, dynasies,《the recorded on the volume:" drug anatkina Budd-by plastering drug yeum, pteroceltis, dry it drug, xiamaling sattle, human and bird, peom and 衾-mantle of all colors, and sufficient."

蓝与白的艺术世界——蓝印花布点击此处查看全部新闻图片蓝印花布源于秦汉，兴盛于唐宋时期，《图书集成》卷中记载：&药斑布-以布抹灰药而染青，候干，去灰药，则青白相间，有人物、花鸟、诗词各色，充衾幔之用。&

You can snipe the second and third union leaders from this position.

您可以鹬第二和第三工会领袖从这一立场出发。

Aiming at the currently shortage of XML streams quality detecting, this paper proposes a new forecasting method of XML streams quality by least squares support vector machines, which is used the method of XML keys' vector matrix as windows, and vector product wavelet transform to multilevel decompose and refactor the XML streams series, that can fulfill real-time checking demand of XML quality, and ensure constraint, consist- ency and integrality. For even more adapting net load, it proposes a control strategy by weight and adaptive adjustment to ensure XML streams quality.

针对当前XML数据流质量检测存在的不足，提出构建XML键的矢量矩阵作为窗口，利用矢量积小波变换多级分解与重构XML数据流，再结合最小二乘支持向量机对XML数据流质量进行预测的一种方法，满足XML数据流质量重构时实时检测的要求，保证XML数据的约束性、一致性与完整性；为了更好的适应网络负载，采取加权与自适应窗口调整等调度策略充分保证XML数据流的质量检测。