查询词典 microglia

IL-1 is elevated in tissue homogenates of temporal lobe and in cerebrospinal fluid from patients with AD. In Alzheimer patients activated immunoreactive IL-1+microglia are increased sixfold over those presenting in age matched controls and the activated IL-1+ microglia are involved in the evolution of diffuse plaque to the diagnostic neuritic plaque. IL-1 is produced by astrocytes and microglia which are components of senile plaques and induced astroglia proliferation.

AD患者颞叶脑组织及脑脊液中发现IL-1含量增高，并且IL-1免疫反应阳性的小胶质细胞比同龄的对照组高6倍，IL-1免疫反应阳性的小胶质细胞与弥散性淀粉样沉淀斑块发展成为具有诊断意义的神经纤维斑块有关。

Moreover, using the intracerebral injection of LTA to evaluate the direct effect of LTA on developing microglia, we showed that ramified microglia labelled with OX-42 or ED-1 progressively retracted their processes then became amoeboid form, indicating that microglia were activated in response to LTA.

另外，利用脑内注射脂壁酸来探讨脂壁酸直接刺激小神经胶细胞的反应，结果显示在注射处有些受OX-42和ED-1标志的分枝状小神经胶细胞，渐渐的收回突起转变成圆形，显示小神经胶细胞有被活化的情况。

Using GSA-〓 lectin histochemistry, the first appearance of microglia occurred at E13, usually stained as scattered amoeboid cells. From then on, the number of microglia increased steadily, reached a peak at postnatal day 7 (P7), and then reduced gradually to adult level. Generally the morphological form of microglia undergoes transformation from early rounded or ameboid to adult resting ramified as they differentiate during development.

使用凝集素GSA-〓亲和组织化学染色，本实验最早观察到小胶质细胞在胚胎13天（E13），为散在分布的圆形或阿米巴样细胞，随后细胞数量逐渐增多；总体而言小胶质细胞的形态遵循着由圆形或阿米巴样逐渐转向纤细分枝状的演变规律，不同阶段细胞形态各有其特点，在不同区域也存在差异；小胶质细胞的数量在生后第七天（P7）达到高峰，其后开始逐步降低直至成年。

Results 1、The CD11b-positive microglia were dyed low brown with small bacilliform cell bodies,ramified morphology,thin and long protuberance in CON and NIC group;In LPS group,the CD11b-positive microglia were dyed chocolate brown with more big roundish cell bodies,thicker and shorter processes;Most CD11b-positive microglia were dyed brown with bacilliform cell bodies,ramified morphology and few cells were dyed deep brown with more big roundish cell bodies,thicker and shorter protuberance in NIC+LPS group.

结果 1、CON组与NIC组CD11b阳性小胶质细胞胞体小，呈杆状，突起细长，染成浅棕色：LPS组小鼠脑内CD11b阳性小胶质细胞胞体增大，呈圆形，突起粗而短，染成棕褐色；NIC+LPS组少量CD11b阳性小胶质细胞胞体增大，圆形，突起变粗变短，染成深棕色，多数呈杆状，突起少、细长，染成浅棕色。

METHODS: The level of intracellular calcium of human microglia grown on coverslip,which was loaded by calcium-probe,Fluo-4,and then treated in various experimental processing,was detected by confocal microscopy with time resolution mode.The binding of gp120 to human microglia was determined with confocal microscopy or flow cytometry after treatment with gp120 and stained with anti-gp120-FITC antibody.Phosphorylation of ERK within human microglia with or without gp120 stimulation was analyzed with confocal microscopy following the direct immuno-staining with anti-phosphorylated ERK antibody.

用钙离子探针Fluo-4标记粘附在盖玻片上的人小胶质细胞，运用共聚焦显微镜以荧光强度为指标实时观察各种条件下的细胞内钙离子水平的变化；用gp120处理并用anti-gp120-FITC进行染色，运用共聚焦显微镜术和流式细胞术分析人小胶质细胞与gp120结合情况；用抗磷酸化ERK 抗体免疫荧光方法进行染色，运用共聚焦显微镜术和流式细胞术进行ERK磷酸化水平分析。

PARTⅡCharacteristic of MMP-9 Activation in Microglia and itsCytokines Secretion after HSV-1 infectedObjective: To investigate the characteristic of MMP-9 activation in microglia and itscytokines secretion.Methods: Balb/c mice were injected intracerebrally with herpes simplex virus type 1(HSV-1) to form herpes simplex encephalitis.

第二部分HSV-1感染小胶质细胞后MMP-9及炎性因子分泌特点研究目的：研究单纯疱疹病毒(HSV-1)感染小胶质细胞系BV2后炎性因子的表达特点，探讨BV2细胞可否作为小鼠单纯疱疹病毒性脑炎模型的替代研究对象。

In addition, the microglia condition medium could attenuate the increase of the phagocytosis and migration abilities of microglia induced by kainite or LPS.

另一方面，此小神经胶细胞条件培养液可以抑制小神经胶细胞因kainate或LPS处理而增加的吞噬及移行的能力，达到抑制小神经胶细胞的活化。

On the other hand, rat primary mixed glia culture was employed to verify the effects of LPS, IFN-γ and Aβ42 oligomers on activating microglia. LPS, IFN-γ, Aβ42 oligomers plus IFN-γ, and Aβ42 oligomers alone effectively activated microglia by changing cell morphology from ramified to amoeboid.

另一方面，利用大鼠的初级胶细胞混合培养来证明LPS、IFN-γ和Aβ42 oligomers对於活化微小胶细胞的影响，我们发现LPS、IFN-γ、Aβ42 oligomers加上IFN-γ和Aβ42 oligomers单独处理皆可以将微小胶细胞的形态由分枝状变成阿米巴状。

While clearance of Abeta probably results in part from microglia-mediated inflammation, it can be microglia independent.

因此，确定小胶质细胞在Abeta清除中的作用对于AD的治疗很重要。

Since microglia is the immune cell in the brain, it plays a defense and monitoring role.

微小胶质细胞为脑中的免疫细胞，扮演著监控与防御的角色。

Hanna: That's over now, isn't it?

都结束了，对吗

You must be ill. You look so pale.

你一定是病了，你的脸色苍白。