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Based on biological experiments, mango glycoside is used as raw material; under the condition with phenol and hydroiodic acid, carbon-carbon bonds are broken to produce the crude product of mango aglycone; the crude product is separated and purified through silica gel column chromatography so that the mango aglycone is separated; the yield rate reaches 12 percent, the purity is higher than 95 percent, and the reproduction performance is good; the IGTT of C57BL/6 normal mice is effectively improved with the norathyriol; and simultaneously the quantity of insulin secretion induced by glucose in vivo for the C57BL/6 normal mice can be improved with the norathyriol.

通过生物学实验证明，本发明所涉及的以芒果苷为原料，在苯酚和氢碘酸条件下，使得碳-碳键断裂，制备得到芒果苷元粗品，再通过硅胶柱层析分离纯化得到芒果苷元的方法使得其产率可达12％、纯度大于95％，且重现性好；norathyriol可使C57BL/6正常小鼠IGTT有明显改善；同时norathyriol可提高C57BL/6正常小鼠体内葡萄糖诱导的胰岛素分泌量。

Zeta potential was -44.23 millivolt. Viscosity was 1.83 mpa. All of which were coincided with physical desire. In addition, the tests of PHGF liposomes including irritation, hemolysis, pyrogen, anomaly toxicity and hypersensibility, proved that the preparation reached the standard of intravenous injection entirely. Taking glutamic pyruvic transaminase and malondialdehyde in mice as index, studies on pharmacodynamics after hepatic injure caused by tetrachloromethane in mice indicated that GPT level (P.001) and MDA yieldment P

以小鼠CCli急性中毒性肝损伤为模型，以动物血清中谷丙转氨酶（GP水平与肝脏中丙二醛p A烨成量为指标，进行PHGF脂质体的药效学试验，结果表明P＊＊F脂质体能显著降低GP T水平o＜0刀01）与MD A 生成量厌＜o.05）；大鼠组织形态的观察表明高剂量＊＊＊F脂质体能使肝脏 0 内皮细胞增生活跃，提高肝细胞的免疫功能，对受损肝细胞具有修复作用；同样小鼠碳廓清试验也显示PHGF脂质体较市售粉针具有更好的机体免 p 疫作用o功刀01），达到制剂设计目的，获得较好的结果。

METHODS: D-galactose (1 000 mg·k-1·d-1 ) was injected into mice hypodermically for 8 weeks to induce aging animal model, and Vit-E (100 mg·kg-1; 250 mg·kg-1) was administered for 6 weeks by ig at the 3rd week of making model. After Vit-E treatment for 8 weeks, water maze test was used to determine the ability of mice's learning and memory. The activities of glutathione peroxidase and succinate dehydrogenase, the content of nitric oxide and activity of nitric oxide synthase in the brain tissue were detected separately.

小鼠连续皮下注射D-半乳糖（1 000 mg·k-1·d-1）8周制备衰老模型，并于第3周开始给予维生素E（100 mg· kg-1；250 mg· kg-1）处理；8周后采用水迷宫测定小鼠学习记忆能力，并取脑组织测定谷胱甘肽过氧化物酶和琥珀酸脱氢酶活性，测定一氧化氮含量和一氧化氮合酶活性。

In mice for 3 days to make immunity hypofunction mice model and given selenocarrageenan syrupus by gastric gavage for 30 days.

小鼠腹腔注射80mg/kg环磷酰胺诱导免疫抑制小鼠模型；硒化卡拉胶口服液连续灌胃30d，每天1次。

There was no significant difference in the average dosage between patients with and without hypohidrosis in each age group. However, there was a significant difference in the average age between patients with and without hypohidrosis in each dosage group.Both developing and mature mice were treated with a low (20 mg/kg/day) and high dose (80 mg/kg/day) of topiramate for four weeks. Each group contained 12 mice.

在控制年龄因素的影响(来源：Abe0e0eBC论文网www.abclunwen.com)后，托吡酯剂量对泌汗障碍的发生无显著影响；而在控制剂量因素的影响后，年龄仍显著影响泌汗障碍的发生。2周龄和2月龄小鼠随机分配至托吡酯低剂量组(20 mg/kg/d)、高剂量组(80 mg/kg/d)和对照组，每组12只。

Methods Eighty Kunming mice were equally randomized into 8 groups: normal group, model group, vitamin E 90 mgkg^(-1d^(-1) group, high-and low-dose RPM protein 20 and 5 mgkg^(-1d^(-1)respectively groups, high-and low-dose RPM anthraquinone glycoside 28 and 7 mgkg^(-1d^(-1) respectively groups, combination (low-dose RPM protein and low-dose RPM anthraquinone glycosides) group. Except the normal group, the mice in other groups received subcutaneous injection of D-galactose to indue the aging model.

选用昆明种小鼠80只，随机分为8组：正常组，模型组，维生素E组（剂量为90mgkg^(-1)d^(-1)），何首乌蛋白质高、低剂量组（剂量分别为20、5mgkg^(-1)d^(-1)），何首乌蒽醌苷高、低剂量组（剂量分别为28、7mg kg^(-1)d^(-1)），AGRPM与PRPM混合组（混合组，均取两者低剂量）；除正常组外，其他组均采用长期（7周）皮下注射D-半乳糖复制衰老小鼠模型。

Methods Eighty Kunming mice were equally randomized into 8 groups: normal group, model group, vitamin E (90mg.kg-1.d-1) group, highand lowdose RPM protein (20 and5 mg.kg-1.d-1 respectively) groups, high and lowdose RPM anthraquinone glycoside (28 and 7mg.kg-1.d-1 respectively) groups, combination (lowdose RPM protein and lowdose RPM anthraquinone glycosides)group. Except the normal group,the mice in other groups received subcutaneous injection of Dgalactose to indue the aging model.

选用昆明种小鼠80只，随机分为8组：正常组，模型组，维生素E组（剂量为90mg·kg-1·d-1），何首乌蛋白质高、低剂量组（剂量分别为20、5mg·kg-1·d-1），何首乌蒽醌苷高、低剂量组（剂量分别为28、7mg·kg-1·d-1），AGRPM与PRPM混合组（混合组，均取两者低剂量）；除正常组外，其他组均采用长期（7周）皮下注射D半乳糖复制衰老小鼠模型。

Methods and Results— Thoracic aortic segments from 8-week-old female B6 and C3H apolipoprotein E–deficient mice were transplanted into the infrarenal aorta of 10-week-old female F1 mice.

方法和背景：将8周大雌性B6和C3H载脂蛋白E缺陷老鼠的胸主动脉节段移植到10周大雌性F1老鼠的肾下主动脉。

Methods Kunming stain male mice were implanted the S180 sarcoma cell in the left hint inguen subcutaneously as an experimental in situ animal model. 7 days after implantation , the mice were given 75mGy whole-body y-ray radiation.

本实验目的在于探讨低剂量辐射对小鼠种植肿瘤细胞的凋亡、细胞周期以及凋亡相关蛋白bcl-2的影响，为低剂量辐射的临床应用提供理论依据。

Methods The effects of O325H were investigated in normal KM mice and two kinds of type 2 diabetic mice by intragastric garage.

灌胃给药，观察O325H对正常小鼠的糖耐量以及对两种2型糖尿病小鼠的降糖降脂作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。