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The result indicates that Bassia rapa L. 65%, 95% alcohol extract and water extract can prolong the survival time of mice in hypoxia under ordinary pressures significantly. It can also prolong the survival time of mice with acute cerebral ischemia and sodium nitrite significantly, and increase the number of erythrocytes and the content of hemoglobin. It demonstrates that Bassia rapa L. extract has anti-hypoxia activity.

结果表明,芫根水提取物、65%乙醇提取物及95%乙醇提取物均能明显延长模型小鼠在常压缺氧、急性脑缺血性缺氧及亚硝酸钠中毒时的存活时间,并可增加外周血象中红细胞数与血红蛋白含量,显示芫根提取物具有抗缺氧活性。

Methods After formation of the experimental diabetic mice models by injecting alloxan with the dose of 120 mg/kg body weight, 30 experimental diabetic mice (20 ± 2g at the beginning) were divided into four groups at random, Group A were given physiological saline as control group, While Group B and C were given low dose ( 125 mg/kg bw) and tfigh dose (250 mg/kg bw) LTN respectively, Group D were given Dimethyl Biguanide Hydrochlorie Aeid.

方法体重(20 2)g清洁级BALB/C小鼠30只腹腔注射四氧嘧啶(120 mg/kg)建立糖尿病动物模型,并将其随机分成4组,分别用生理盐水、低剂量(125mg/kg)和高剂量(250mg/kg)香菇多糖以及盐酸二甲双胍灌胃,试验期21 d,观察、比较香菇多糖的作用。

Objective: Bletilla Striata polysaccharide was used to stimulate the whole blood of the ICR mice. The mRNA and protein levels of all the inflammatory factors and coagulation factors in the whole blood were determined at different time intervals in order to investigate the molecular mechanism of BSP on the pathway of inflammation and coagulation. Methods:The whole blood was obtained from the ICR mice and stimulated by BSP.

目的:用白芨多糖刺激全血,检测不同刺激时间全血中各种炎症因子和凝血因子在mRNA水平和蛋白质水平的表达量,探讨白芨多糖作用于炎症和凝血通路的分子机制。

objective the effects of anthocyanin pigment from maize purple plant on resisting lipid peroxidation were investigated.methods the inhibition of anthocanin pigment from maize purple plant was examined in vitro that autcoxudation of lecithin liposome system induced by fe2+.50 mice were randomly divided into 5 groups.vehicle and different dose anthocyanin pigment from maize purple plant were given respectively,and then experimental injury of mice liver was induced to make use of bromobenzene and the content of mda was determined in liver homogenate.results the inhibition rates of anthocyanin pigment from maize purple plant on linoleic acid oxidation was higher that of ascorbic ascorbic acids.the content of mda in homogenate in middle and high dose of pigment were significantly lower than that in low dose and the injured control group.there were no significat differences in the content of mda in homogenate between low dose group and injury control group.conclusion the anthocyanin pigment from maize purple plant have the capability to resist lipid peroxide.

目的 探讨玉米紫色植株色素抗脂质过氧化的作用。方法体外实验测定玉米紫色植株花色苷色素在fe2+引发的卵磷脂脂质体体系中抗氧化活性。体内实验,取50只小鼠随机分成5组,分别给予溶媒和不同剂量的色素,然后采用溴代苯致实验性肝损伤,测定肝匀浆的丙二醛含量。结果在由fe2+引发的卵磷脂脂质体体系中玉米紫色植株色素对脂质过氧化有明显的抑制作用,抑制率随样品的浓度增高而增大,并且明显优于抗坏血酸。在溴代苯致小鼠实验性肝损伤模型实验中,中、高剂量组的丙二醛含量均低于损伤模型组。低剂量组和损伤模型组比较丙二醛含量差异无统计学意义。

Methods Spontaneous aged dementia mice were screened out from 21 months old Kunming mice and then were divided randomly into 4 groups, namely control, westernmedicine, lower dosage Bugan Yangsui formula and higher dosage Bugan Yangsui formula group.

从 21 月龄昆明种小鼠筛选出自发老年性痴呆鼠,随机分为 4 组即空白对照组、西药对照组、补肝养髓小剂量组、补肝养髓大剂量组、另设老年学习记忆正常组。

Results In lead poisoning group, the pathological changes in genital glands of mice were obtained; sperm count, linear movement sperm and live sperm rate decreased; the elevated motionless sperm, cacospermia and primary spermatocyte chromosome aberration rate were found. In Haierfu group, the pathological changes in genital glands of mice ameliated to different degree, sperm count, linear movement sperm and live sperm rate elevated, and motionless sperm, cacospermia and primary spermatocyte chromosome aberration rate decreased.

结果 醋酸铅染毒组雄性小鼠的生殖腺有不同程度的病理学改变,精子计数、直线运动精子数、活精子率下降,而静止不动精子数、精子畸形率和初级精母细胞染色体畸变率升高;海尔福治疗组小鼠的生殖腺病理学改变有不同程度的改善,精子计数、直线运动精子数、活精子率有所升高,而静止不动精子数、精子畸形率和初级精母细胞染色体畸变率有所降低。

The immuneological functions of watery extract, sixty-five and ninety-five percent of ethanol extracts of Caesalpinia Sappan L. in mice were studied. It was reviewed that extracts had effects on the production of hemolysin antibody by CRBC and meshy endothelium phagocytosis function in mice.

利用水、65%、95%乙醇提取物进行了免疫药效学的动物实验研究,考察了上述提取物对红细胞所致的小鼠溶血素抗体生成的影响以及小鼠网状内皮系统对血流中惰性碳粒的吞噬功能的影响。

Although the couplets number and morphology are similar in both genotypes, fluorescence assay showed significantly decreased bile secretion into canalicular space of hepatocyte couplets in AQP8 null mice compare with wild type mice.

为了避免胆管对胆汁形成修饰作用,我们使用胆盐刺激小鼠,加快胆汁分泌的速度,结果仍显示,AQP8基因敲除小鼠的胆汁分泌量明显少于野生型小鼠。

ResultsBoth wild and cultivated Polygonun capitatum could inhibit cotton-induced granuloma of mice, and inhibit twisting response of mice obviously.

结果野生与栽培头花蓼对小鼠腹腔毛细血管通透性、小鼠足肿胀、小鼠耳肿胀和棉球肉肿等炎症具有明显的抑制作用;对醋酸引起的扭体反应有明显的镇痛作用;相同剂量的野生与栽培头花蓼之间没有明显差异。

Analgesic action of wild and cultivated Polygonun capitatum was observed by aceticacid-induced twisting test.ResultsBoth wild and cultivated Polygonun capitatum could inhibit cotton-induced granuloma of mice, and inhibit twisting response of mice obviously. In the same dose, there had no significant difference between wild and cultivated Polygonun capitatum.

结果野生与栽培头花蓼对小鼠腹腔毛细血管通透性、小鼠足肿胀、小鼠耳肿胀和棉球肉肿等炎症具有明显的抑制作用;对醋酸引起的扭体反应有明显的镇痛作用;相同剂量的野生与栽培头花蓼之间没有明显差异。

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