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In conclusion, these results suggested that (1) the ageing-associated decline in fertility of female KM mouse was due to a decrease in both quantity and quality of oocytes;(2) the ooplasm from young mice did not correct the meiotic errors of aged mice, and the ooplasm from aged mice did not induce abnormal segregation of meiotic chromosome of young mice, indicating that meiotic anomalies found in the oocytes of aged mice might be related to nucleus or chromosomes and relevant factors;(3) a critical nucleocytoplasmic ratio was essential for normal maturation and segregation of meiotic chromosomes of oocytes and development to 2-cell embryos.

本研究结果表明：（1）昆明白小鼠与衰老相关的生育力下降是其卵母细胞数量减少和质量下降的综合结果；（2）年轻小鼠卵母细胞细胞质不能纠正老龄小鼠GV的减数分裂错误，老龄小鼠卵母细胞细胞质也不诱导年轻小鼠的GV发生减数分裂错误，老龄小鼠卵母细胞减数分裂异常很可能与细胞核或染色体及其相关因素有关；（3）关键的核质比对卵母细胞正常的成熟、减数分裂染色体分离及2-细胞期胚的发育是绝对必需的。

Methods After taking triazolam and distilled water respectively, the mice sleeping-behavior state was observed and recorded; the ratio of sleeping mice was recorded after taking different of ingredients Eucommia ulmoides Oliv. combining with pentobarbital sodium at subliminal dose, and mice latent period and sleeping time at supraliminal dose. Measure the content of interleukin-1β(IL-1β) in mice brain with enzyme-linked immunosorbent assay, weigh spleen and thymus of mice.

通过观察记录日间小鼠睡眠行为状态，戊巴比妥钠阈下催眠剂量实验，延长戊巴比妥钠睡眠时间实验，酶联免疫吸附反应分别检测服用3种不同极性的提取部位、阳性对照物和空白对照组的小鼠脑组织中IL-1β含量，并结合脏器指数等综合分析。

Pre-experimental results showed, sensitivity varied among mice speaces, C57BL/6J mice were more sensitive to endotoxin than Balb/c mice, Balb/c mice were more sensitive than Kunming mice.

预实验的结果显示，C57BL／6J小鼠对内毒素的敏感程度大于Balb／c小鼠，Balb／c小鼠对内毒素的敏感程度大于昆明鼠。

Results The extract of Huanglian Xiangru Decoction with different proportions of herbs could inhibit pathological changes in lung of mice caused by FM1 strain of Influenzavirus A and lower lung index, indicating anti-influenza activities in vivo with antifebrile effects on febrile rats caused by yeast, resistance to acute inflammation of auricular swelling of mice caused by paraxylene, decreasing writhing times of mice caused by glacial acetic acid, and increasing pain threshold of mice caused by hot plate.

结果 不同比例的黄连香薷饮提取物可明显抑制甲Ⅰ型流感病毒FM1株引起的小鼠肺部病变、降低肺指数，有体内抗流感病毒作用，对酵母所致发热大鼠有退热作用，对二甲苯所致小鼠耳廓肿胀有抗急性炎症的作用，有减少冰乙酸致小鼠疼痛扭体次数和提高热板致痛小鼠痛阈值的作用。

Two different murine models (IFN γ or IL 4 gene knockout C57BL/6 mice,15 mice each strain) were contagiously infected with P.carinii by cohousing with P.carinii positive mice for 3,5,7 weeks as well as 15 gene un knockout C57BL/6 mice for infection control group.

分别用IFN γ或IL 4基因敲除的C5 7BL 6小鼠(各 15只作为动物模型)与未经基因敲除的C5 7BL 6小鼠(15只作感染对照组)，以密切接触的方式，使小鼠自然感染卡氏肺孢子虫；同时设非感染组 15只小鼠作阴性对照。

Objective: To investigate immunostimulatory activity of CpG ODN against immunosuppression mice, aged mice, pregnant mice and their newly born mice; To screen a CpG ODN that its immunostimulatory activity against human cord blood lymphocytes is stronger than others; To observe immunostimulatory activity of CpG ODN against premature infants cord blood lymphocytes and to observe its cytolysis against Kse2 cells.

摘要目的：探讨CpG ODN对免疫抑制小鼠、老年鼠、孕鼠及其新生小鼠的免疫刺激作用；筛选对人脐血淋巴细胞免疫刺激作用较强的一种CpG ODN；观察其对早产儿脐血淋巴细胞的免疫刺激作用及刺激NK细胞对K_(562)细胞的杀伤活性，为开发适合人类新型疫苗佐剂奠定基础。

Methods The model of cerebral ischemia and anoxia in mice was established by decollation and ligating common bicarotid artery the effect of BVF on the survival time of the mice,and the time of catching their breath after mice decollated,and mouse brain capillary vessel permeability were observed. The content of maiondialdehyde,activity of superoxide dismutasein the brain tissues of cerebral ischemia and anoxia mice were measured by TBA,NBT technology respectively.

采用小鼠断头、结扎双侧颈总动脉等脑缺血缺氧模型，观察苦菜总黄酮对脑缺血缺氧小鼠存活时间、断头小鼠喘息时间及脑毛细血管通透的影响；TBA法、NBT法测定小鼠脑缺血缺氧后脑组织MDA含量和SOD活性。

objective to study the anti-tumor activity and enhancing immune effect of phellinus linteus.methods the anti-tumor activity of phellinus linteus was estimated by the longevity of eac mice,the immune effect of tumorous mice was tested by the experiment of carbon particle expurgation and the il-2 concentration in serum of tumorous mice was determined by elisa.results phellinus linteus can prolong eac mouse's life and can increase the il-2 concentration in serum of tumorous mouse but can't affect the immune effect of tumorous mouse.conclusion chinese hurb phellinus linteus possess some antitumor power for tumor-loaded mice,but further research is needed.

目的 观察桑黄对肿瘤的抑制作用及对机体免疫功能的影响。方法以小鼠艾氏腹水癌的生命延长率评价桑黄的抗肿瘤作用，以炭末廓清实验观察荷瘤小鼠非特异性免疫功能，以elisa法测定荷瘤小鼠血清il-2浓度。结果桑黄对eac荷瘤小鼠的生存时间有延长作用，对荷瘤小鼠血清il-2浓度有提高作用，对荷瘤小鼠非特异性免疫功能无明显影响。结论中药桑黄对荷瘤小鼠具有一定的抗肿瘤能力，作用的强度和作用机制的深度还有待进一步研究。

Results The serum antibody level reached to 0.71±0.08-0.77±0.06 after genetic vaccine pCD-HCV1(100 μg/mouse) were inoculated into the mice(n=12) three or four times while blank vector pCD-SRα1 could not induce the mice(n=8) to generate antibody response in same way.After the antibody levels in mice(n=8) immunized by pCD-HCV1 had ascended to peak value(0.71), there was no trend of descending during the following 18 weeks of detection(0.68±0.06-0.75±0.07). Specific fragment of HCV cDNA identified by polymerase chain reaction from DNA extracted from the muscles of the mice after pCD-HCV1 had beed inoculated three months.

结果 基因疫苗pCD-HCV1(100 μg/只)3-4次接种小鼠后(n=12)，血清抗体水平达0.71±0.08-0.77±0.06，空载体pCD-SRα1免疫鼠血清抗体阴性；免疫鼠(n=8)抗体水平达高峰后(0.71)，持续检测18周未见下降趋势(0.68±0.06-0.75±0.07)；pCD-HCV1免疫小鼠3个月后，用聚合酶链反应仍可从肌肉组织中扩增出特异性HCV cDNA片段；免疫鼠PBMC对HCV合成肽CP9、基因重组抗原C、E1刺激后均出现增殖反应，刺激指数分别为4.07±1.58、3.88±0.70和3.69±1.30，与pCD-SRα1免疫鼠相比，差异有显著性(P.001)。

The mice were divided into three groups: a cardiac isograft of C57BL/6 to C57BL/6 mice; b cardiac allograft of Balb/c to C57BL/6 mice; c cardiac allograft of Balb/c to C57BL/6 mice with mfgl2 polyclonal antibody treatment.

采集移植心组织标本作病理学检查，以免疫组织化学方法测定mfgl2在移植心脏组织细胞上的表达，并对mgfl2的表达进行半定量分析。

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