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Therefore, based on documents reports, through contrastive observation of 20-month-old natural senile mice, this study has confirmed that the anaplasia of subacute senile model mice was obviously similar to the features of 20-month-old naturally physiological senile mice. Mice in both two groups displayed dull color patterns, slow movements, insensitive responses and decrease of growth rates of body weight; hepatic and brain tissues in the mice presented senile features of sero-enzyme such as decrease in SOD activity, increase in content of lipid perhydrides and so on.

为此,本研究在文献报道基础上,通过与20月龄自然老化鼠的对比观察,证实:亚急性衰老模型鼠的退行性变化与20月龄自然生理性老化鼠特征的相近之处鲜明可见。2组均出现毛色暗淡,少有光泽,动作迟缓,反应不灵敏,体重增长率下降;肝、脑组织出现SOD活力下降,脂质过氧化物含量增高等血清酶学的老化特征。

Results The GRK5 protein level in Parkinson's disease α-synuclein transgenic mice was increased to different degrees compared with that in non-transgenic littermate control mice, and the protein and mRNA expressions of GRK5 in 9-month old A53T mutant mice were higher than those in NLC mice, but there were no significant changes in the 3 month and 6 month old A53T mutant mice.

结果 各组帕金森病α-synuclein转基因小鼠与阴性对照小鼠相比,GRK5蛋白表达水平均有不同程度的增加,并且随着转入的h-α-syn蛋白表达水平的高低而有所变化。3月龄和6月龄帕金森病转基因模型小鼠与同月龄阴性对照组小鼠相比,GRK5的mRNA和蛋白水平没有变化;而9月龄帕金森病转基因模型小鼠与同月龄阴性对照组小鼠相比,GRK5的mRNA和蛋白水平都有所增加。

To observ the toxicity of infected mice and establish mice reproductive toxicity model;②To observe the infected BALB/c female mice ovulation quantums and ovum chromosome;③To observe the oestrogenic hormone( FSH, LH, E2 )level of infected BALB/c female mice;④To observe zygote developmental condition before nidation;⑤To observe embryonic development condition of infected mid-gravidity mice to research the reproductive toxicity and development toxicity of toxoplasma gondii to the BALB/c female mice.

目的: 本实验采用弓形虫感染BALB/c雌鼠,①观察染虫雌鼠的毒性反应,建立生殖毒性的小鼠模型;②染虫雌鼠排卵情况及卵母细胞染色体的变化;③染虫雌鼠性激素(FSH、LH、E2)水平的变化;④着床前受精卵的发育情况;⑤孕中期鼠染虫后胚胎的发育情况,探讨弓形虫对雌鼠生殖功能及胚胎发育的毒性作用。

Results In the aspect of oocyst intensity discharged from mice, femal BABL/C mice were more than the male, the 50 day-old mice(26 g~28 g) were more than the 25 and 75 day-old, mice in 15 mg/L group were more than those in the and mice infected after immunosuppressed for 3 days were more than those infected after immunosuppressed for –6,-3,0,6,9 days.

结果 雌性小鼠排卵囊强度均较同日龄雄性小鼠大,而不同日龄小鼠中又以50日龄(26 g~28g)小鼠排卵囊量最多;各剂量组小鼠中,15 mg/L组排卵囊强度较其他各组大,10 mg/L组小鼠次之;免疫抑制时间各组中,免疫抑制3天后感染的小鼠排卵囊强度较其他组大。

The8 transgenic mice lactated naturally .and centrifuge to discard the fatness and the acid. At last ,we got the serum of the milk of 5 transgenic mice and 2 normal mice , checked the human insulin in serum by RlA.The result of the CPM show that two transgenic mice are conspicuous excess to the other transgenic mice and normal mice .and the mount of human insulin achieve respectively to 250uIU/ml ,376 ulU/ml.

转基因小鼠自然泌乳以后,收集到5只转基因小鼠和2只阴性小鼠的乳汁,脱脂脱酸以后,在乳清中用放射免疫检测方法检测胰岛素的表达量,结果其中两只转基因小鼠的表达量明显高于其它小鼠,表达量达到250uIU/ml和376uIU/ml,进一步的蛋白质定性和活性检测正在继续进行中。

Results In dioestrous mice, many iNOS+ cells were found in the stroma of endometrium. There was no obvious differences between the immunized mice and the control mice. In the uterus on 3 day of pregnancy, however, there was obvious difference about the iNOS quantity in uterus between the immunized and the control mice. There was strong positive reaction on the epithelia of endometrium and the endometrial gland in the lamina propria in control mice, while the staining of iNOS in the uterus of SA-30 immunized mice was very weak, only a few of iNOS+ cells were observed in the myometrium.

结果 SA-30免疫后对间情期小鼠子宫内的iNOS没有明显影响,无论是免疫组还是对照组,在子宫内膜基质中均有大量阳性细胞分布,两者无明显差异;在妊娠第3d时,对照组的小鼠子宫中有较多iNOS表达,阳性标记主要集中在内膜上皮及固有膜中的子宫腺上,经SA-30免疫的小鼠子宫中,iNOS表达则显著减少,整个内膜标记极弱,只在子宫肌层内有少量iNOS阳性细胞分布。

Results In dioestrous mice, many iNOS+ cells were found in the stroma of endometrium. There was no obvious differences between the immunized mice and the control mice. In the uterus on 3 day of pregnancy, however, there was obvious difference about the iNOS quantity in uterus between the immunized and the control mice. There was strong positive reaction on the epithelia of endometrium and the endometrial gland in the lamina propria in control mice, while the staining of iNOS in the uterus of SA-30 immunized mice was very weak, only a few of iNOS+ cells were observed in the myometrium.

结果 SA-30免疫后对间情期小鼠子宫内的iNOS没有明显瘙痒影响,无论是免疫组还是对照组,在子宫内膜基质中均有大量阳性偏瘫细胞分布,两者无明显瘙痒差异;在妊娠第3d时,对照组的小鼠子宫中有较多iNOS表达,阳性标记主要集中在内膜上皮及固有膜中的子宫腺上,经SA-30免疫的小鼠子宫中,iNOS表达则显著减少,整个内膜标记极弱,只在子宫肌层内有少量iNOS阳性偏瘫细胞分布。

ResultsResina Draconis had no obvious effects of decreasing the serum glucose level in normal mice, but could decrease the serum glucose level in alloxan induced diabetic mice. Also, Resina Draconis improved the sucrose resistance in normal mice and diabetic mice and increased insulin in normal mice. Some of components of Resina Draconis had been measured in serum sample.

结果龙血竭提取物对正常小鼠空腹血糖无明显降低作用,能降低四氧嘧啶糖尿病模型小鼠的空腹血糖水平,能改善小鼠对蔗糖的耐受力,增加正常小鼠的胰岛素分泌,血清样本中有药物成分检出。

ResultsResina Draconis had no obvious effects of decreasing the serum glucose level in normal mice, but could decrease the serum glucose level in alloxaninduced diabetic mice. Also, Resina Draconis improved the sucroseresistance in normal mice and diabetic mice and increased insulin in normal mice. Some of components of Resina Draconis had been measured in serum sample.

结果龙血竭提取物对正常小鼠空腹血糖无明显降低作用,能降低四氧嘧啶糖尿病模型小鼠的空腹血糖水平,能改善小鼠对蔗糖的耐受力,增加正常小鼠的胰岛素分泌,血清样本中有药物成分检出。

Results: B6-Co mice showed higher sterile rate, and significant lower average litter size and survival rate at weaning than the normal B6 mice, but the time interval between deliveries was shorter in the mutant population. During the first two weeks after birth, the growth performances were not significant between the mutant mice and the normal ones, but after that, the mutant mice grew much slower. The differences were significant in the indexes of eyes, lungs, thymuses, and adrenal glands between the genders. At the same time, the differences were significant in the organ indexes, such as lungs, adrenal glands, uterine and testicles between the normal phenotype mutant mice and the abnormal ones. And these two kinds of mice showed different amount of hemoglobin and red blood cell.

结果:B6-Co小鼠不育率22%、平均产仔数5.62±2.55只、离乳成活率56.59±41.22显著低于正常的B6小鼠,而胎间隔29.50±10.50天比正常B6小鼠短。B6-Co小鼠出生后2周内生长发育与正常B6小鼠基本一致,2周后,其生长发育慢于正常B6小鼠。B6-Co小鼠雌雄间的眼球、肺、胸腺、肾上腺的脏器指数差异有统计学意义。B6-Co表型异常小鼠与B6-Co表型正常小鼠相比,肺、肾上腺、子宫、睾丸的脏器系数差异有统计学意义。B6-Co小鼠表型异常小鼠在血红蛋白和红细胞数量上异于B6-Co表型正常小鼠。

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相关中文对照歌词
The Best Laid Plans Of Mice And Marionettes
We Are Mice
Mice & Gods
Blind Mice
Three Blind Mice
Sugar Mice
Of Mice And Men
Mice Eat Cheese
Thank You (Falettinme Be Mice Elf Agin)
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