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Methods The analgetic effect was demonstrated using pain models induced by acetic acid and hot board on mice. The Nvzhendan Granula antiinflammatory effect was demonstrated in rats using inflammatory models including auricle edema induced by xylene in mice,and paw edema induced by carrageenin.

采用醋酸和热板致痛法观察复方女真丹颗粒的镇痛作用;采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足肿胀炎症模型观察复方女真丹颗粒的抗炎作用。

the analgesic effect of water decoction of caulis spatholobi was observed by mice writhing test, mice tail-immersion test and hot-plate test,with three concentrations (25%,50% and 100%).

采用小鼠热板法、小鼠醋酸扭体法和小鼠热水缩尾法观察25%、50%和100%三种浓度的鸡血藤水煎液的镇痛作用。

The transmission electron microscope was used to observe the ultrastructural damage in the cere- bellar cortex of the pregnant mice and fetal mice.

结果 1、妊娠期母鼠接触MTBE浓度为400、800mg/kg.bw时,胎鼠大脑皮层、小脑皮层和海马nNOS和神经递质Glu的表达随着染毒剂量增加而减少(P.05)。

Results Being compared with the normal group, the PDS mice showed a slower growth of body weight and a lower body temperature, a shorter mean retention time of chyme in digestive tract and faster gastric emptying velocity, a lower gastrin content, and a higher motilin content. Also splenic and thymus indexes were found to follow a downtrend in the PDS mice. Three dosages of SJZD showed a restoration effect on the above all indexes, and the high dosage was the most effective one, especially.

结果脾虚证小鼠体重增长缓慢,体温降低、消化道内食糜平均滞留时间缩短、胃排空加快、胃泌素的量降低、胃动素的量升高,脾脏和胸腺指数降低。3种剂量的四君子汤对脾虚证小鼠以上各指标的变化均有明显的矫正作用,以高剂量效果最佳。

The old mice maintained liver function efficiency comparable to six-month-old mice.

这些年老的老鼠保持了与6个月大的老鼠一样高效工作的肝脏。

MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型,分析灌胃小鼠各药的量效和时效关系,比较其效价强度和效能;②采用戊四唑惊厥模型,比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率;③采用药效法,运用数学模式及参数来模拟各药在体内的药效动力学过程;④制备大鼠皮层定位注射青霉素点燃模型,采用RM6240C型多道生理信号采集处理系统记录脑电图,比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响;⑤采用HPLC法测定海马区癫痫相关递质的含量,比较各药对Glu、Asp、Gly、GABA的影响。

The study of mechanism of its anti-inflammationThis experiment shows that NTL can inhibit the edema of hind paw induced by fresh egg white in adrenalectomized rat, reduce the weight of thymus in rat, increase the content of hepatic glycogen ,but decrease eosinophil of mice through experimentalstudy of effect of NTL on edema of hind paw induced by fresh eggwhite in adrenalectomized rat, weight of thymus in rat, content ofhepatic glycogen and eosinophil of mice. The results indicate that NTL has the analogous function to cortin.

抗炎机理研究通过虎斑游蛇对去肾上腺大鼠蛋清性足跖肿胀、对大鼠胸腺重量和对小鼠肝糖原含量及对小鼠嗜酸性粒细胞数量影响的实验研究,表明虎斑游蛇能够抑制去肾上腺大鼠蛋清性足跖肿胀,使小鼠胸腺的重量减轻,增加小鼠肝糖原的含量而减少嗜酸性粒细胞的数量,提示虎斑游蛇具有肾上腺皮质激素样作用。

For further investigation, we constructed cardiomyocyte-specific RGS4 transgenic mice and crossbred them with GC-A-KO mice.

我们构建心肌特异的RGS4转基因小鼠并将它与GC-A基因敲除小鼠杂交以做进一步研究。

METHODSThe auricle inflammation models were made with xylene and croton oil to investigate the effects of Purslane extracton auricel swelling in mice.The acetic acid twisting body test and the hotplate test were used for the study of analgesic effects of the ethyl acetate extract in mice.

方法]采用二甲苯及巴豆油致小鼠耳廓炎症的方法,观察马齿苋提取物对小鼠耳廓肿胀度的影响;采用扭体法和热板法,观察对小鼠镇痛作用的影响。

Objective: To observe the effect on the expression of BDNF and bFGF in cerebral cortex of C57BL/6 mice infected with Cryptococcus neoformans. Methods: Forty- eight C57BL/6 female mice were randomly divided into experiment group (received 10^6 cells of C.

文章摘要:目的:观察C57BL/6小鼠感染新生隐球菌后对大脑皮质BDNF和bFGF表达的影响,并探讨BDNF和bFGF在新生隐球菌感染过程中的作用及其意义。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

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