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AIM: To evaluate the effects of Brucine on restraining transplanted tumor growth, prolonging the mice survival time, and to examine its influence on immune organ index in mice transplanted with tumor cells.

目的：评价马钱子碱对移植性肿瘤模型荷瘤小鼠的肿瘤抑制作用和生存时间的影响。

Type Ⅱ collagen-induced arthritis in mice,which shares similar characteristics with rheumatoid arthritis,was used as the mode for RA in this study,by taking the incidence,arthritis index,the level of anti-collagenase Ⅱ antibody,the histo-pathological changes as quotas,we observed cantharis plaster's effect on the model by applicating it on acupoints,and measured the splenic interleukin-1 β level of collagen-immunized mice.

采用与类风湿性关节炎特征相似的小鼠胶原诱导性关节炎(Collagen-induced arthritis，CIA)模型，以关节炎发病率、关节炎指数、抗Ⅱ型胶原抗体水平、组织病理学改变等为指标，观察了斑蝥膏穴位敷贴对此模型的影响，并检测了胶原免疫小鼠脾脏白介素-1β水平。

Methods the models of xylene-induced ear edema in mice, hind paw edema induced with carrageen in rats, granuloma induced with cotton ball in rats, and capillary permeability increase induced with acetic acid in mice were used to observe the anti-inflammatory effects.

目的 研究岗梅水提取物的抗炎作用。方法采用二甲苯致小鼠耳廓肿胀法、角叉菜胶致大鼠足跖肿胀法、大鼠棉球肉芽肿法和醋酸致小鼠毛细血管通透性增高法观察岗梅水提取物的抗炎作用。

Methods Analgesic effects of Shengning suppository were observed with pain model mice by acetic acid or hot plate test. Antiinflammatory effects were studied with ear acute edema model induced by dimethylbenzene in mice and rat foot edema model induced by carrageen, and antipruritic action was observed with allergic pruritic model caused by histamine in guinea pigs.

采用二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致大鼠足跖肿胀炎症模型，热板法和扭体法及磷酸组织胺的致痒试验，观察参宁栓的抗炎、镇痛、止痒作用。

Methods The mice were given the meloxican tablet, ig, at the dosage of 0.56,1.13,2.25 and 9.00 mg.kg-1, then ip 0.8%acetic acid, and injecting the ear of mice. The meloxicans were given to rats, at the dosage of 1.5,3.0,6.0 mg.kg-1, to observe the effect of the meloxican inhibiting the paws swelling of rats by carrageen and granulation of rats by paper method.

观察美洛昔康对醋酸导致小鼠血管通透性增加和二甲苯引起小鼠耳肿胀抑制作用，以及角叉菜胶诱发大鼠足肿胀和纸片法引起大鼠肉芽增生的抑制作用。

The ear edema of the normal and adrenalectomized mice induced by croton oil, vascular permeability formed by histamine in mice and hind paw edema caused by Carrageenin in rats were used to determine the inhibition to acute inflammnation.

提取物对急性炎症的抑制作用采用巴豆油引起的正常小鼠和摘除肾上腺小鼠的耳肿胀、组胺引起的小鼠毛细管通透性以及角叉菜胶引起的大鼠足肿胀进行分析。

It could also suppress paw edema induced by carrageenin in rat and writhing induced by acetic acid in mice, but has no effect on the ear swelling caused by dimethylbenzene and cotton granulation hyperplasia and latent period of pain reaction in tail immersion test in mice.

对角叉菜胶致大鼠足肿胀和醋酸致小鼠扭体反应有一定的抑制作用，但对二甲苯致小鼠耳肿胀、小鼠棉球肉芽肿增生、小鼠温浴致痛反应潜伏期无明显影响。

Results The extract remarkably inhibited the contraction caused by histamine and acetylcholine, as well as the ovalbumin sensitized allergic constriction of isolated ileum smooth muscle of guinea pigs. It could inhibit the increase of capillary permeability induced by acetic acid in mice, inhibit the mice paw edema produced by carrageenin and reduce the production of PGE 2 in inflammatory tissues.

结果：辛夷二氯甲烷提取物对组胺、乙酰胆碱（Ach引起的豚鼠离体回肠收缩具有显著的抑制作用，并能抑制卵白蛋白所致的豚鼠离体回肠过敏性收缩，对HAc引起的小鼠腹腔毛细血管通透性增高具有抑制作用，能显著抑制角叉菜胶引起的小鼠足肿胀，并减少前列腺素E2（PGE2）在炎症组织中产生。

RESULTS Xiaocuoling at the concentration of 2.5、5.0、10.0g.kg-1 obviously inhibited the paws swelling induced by carrageenin in mice and the granuloma with cotten pellet in rats,decreased the penetration of blood capillary caused by histamine,increased the activity of peroxide hydrogenase in RBC,reduced the reaction of the torsive body induced by acetic acid in mice,and had no effects on the serum concentrations of testosterone of serum in male rats.

结果：消痤灵颗粒 2.5、5.0、10.0g.kg-1可显著抑制角叉菜胶所致的小鼠足趾肿胀和大鼠棉球肉芽肿，降低由组胺诱导的小鼠皮肤毛细血管通透性的增加，提高红细胞过氧化氢酶的活力。对乙酸致小鼠扭体反应有抑制作用。对雄性大鼠血清睾酮含量无影响。

Result: Xinhuang Tablet had very significant inhibition on acute and chronic inflammation in model of ear edema induced by croton oil in mice, paw swelling induced by carrageenin in rats, granuloma induced by cotton pellet in rats and very significant analgesic effect on thermal and chemical stimulation in model of writhing body response induced by acetic acid in mice and tail flicking in rats.And at the same doses, Xinhuang Tablet hadn't significant difference from ig administration.

结果：新癀片外涂给药对小鼠耳肿、大鼠角叉菜胶足肿、棉球肉芽肿等急、慢性炎症有非常显著的抑制作用；对大、小鼠水浴甩尾、小鼠醋酸扭体等温热刺激、化学刺激引起的疼痛有非常显著的镇痛作用，且在相同剂量下，外涂给药和ig给药的作用无明显差异。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。