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The mutagenicity of seed powder and seed oil of transgenic CryIA cotton to mammals and fish was evaluated in this study. The raw cotton seed powder or seed oil was mixed into mice and fish's diet. Cyclophosphamide and NaF were used as positive controls respectively. Regular cotton seed powder and seed oil were used as negative controls. The micronucleus frequency in mice bone marrow polychromatic erythrocytes and in eripheral erythrocytes of Zebrafish were assayed in this study. The sperm malformation rate in mice was also investigated.

摘 要：分别以环磷酰胺和氟化钠作为阳性诱变剂，以普通棉的棉籽粉及棉籽油作为对照物，同时设阴性对照组，以成年封闭群昆明种雄性小鼠和斑马鱼为实验材料，将棉籽粉或棉籽油掺入饲料中饲喂小鼠或斑马鱼，检测小鼠骨髓嗜多染红细胞（Polychromatic erythrocytes， PCE）微核率（Micronucleus frequency， MN‰）和精子畸变率，以及斑马鱼外周血红细胞微核率。

The mutagenicity of seed powder and seed oil of transgenic CryIA cotton to mammals and fish was evaluated in this study. The raw cotton seed powder or seed oil was mixed into mice and fish's diet. Cyclophosphamide and NaF were used as positive controls respectively. Regular cotton seed powder and seed oil were used as negative controls. The micronucleus frequency in mice bone marrow polychromatic erythrocytes and in eripheral erythrocytes of Zebrafishwere assayed in this study. The sperm malformation rate in mice was also investigated.

分别以环磷酰胺和氟化钠作为阳性诱变剂，以普通棉的棉籽粉及棉籽油作为对照物，同时设阴性对照组，以成年封闭群昆明种雄性小鼠和斑马鱼为实验材料，将棉籽粉或棉籽油掺入饲料中饲喂小鼠或斑马鱼，检测小鼠骨髓嗜多染红细胞（Polychromatic erythrocytes， PCE）微核率（Micronucleus frequency，MN‰）和精子畸变率，以及斑马鱼外周血红细胞微核率。

Histamine deficiency markedly potentiated the acquisition of learning in cued and contextual fear conditioning in the HDCKO mice,but had no effect on cued and contextual fear extinction.However,histamine deficiency potentiated the inhibitory role of morphine withdrawal in cued fear extinction.Consistent with the behavioral results,morphine withdrawal decreased ERK phosphorylation in the amygdala and mPFC but not in the hippocampus of WT and HDCKO mice,and ERK might not be phosphorylad in the amygdale and mPFC of HDCKO mice after the 4th training of cued fear extinction.

但HDCKO小鼠增强了吗啡戒断对线索恐惧记忆消除的抑制作用，与行为学实验结果相一致是，，吗啡戒断能明显降低WT和HDCKO小鼠在线索恐惧记忆消除第4次训练后杏仁核和mPFC脑区的ERK磷酸化水平，但对海马脑区的ERK磷酸化没有作用；HDCKO小鼠在线索恐惧记忆消除训练的第4次训练后杏仁核、mPFC脑区的ERK蛋白没有明显磷酸化激活。

The LD50 of acute toxicity to mice and chronic accumulated toxicity to bandicoots of crude and processed Radix Aristolochice were observated.Intestinal and myokinetic influence of normal and revulsive hyperactive gastrointestinal motility of mice induced by neostigmine were observated by giving aqueous extract and alcoholic extract of crude and processed Radix Aristolochice.Relieving pain and eliminating inflammation to mice also were observated .

采用小鼠急性毒性和大鼠蓄积性毒性方法观察青木香炮制前后对小鼠急性毒性LD50和对大鼠的慢性蓄积性毒性作用；观察了青木香炮制前后的水煎剂和醇提物对正常和新斯的明诱导的胃肠运动机能亢进小鼠肠肌运动的影响；并观察了对小鼠的镇痛和抗炎作用。

In this work, it was found that MT at the concentrations of 〓 and 〓 mol·〓 could enhance the proliferation in rats and mice thymic lympho- cytes and human PBL as well as enhancing the proliferation in AA rats, 11 months mice and Mor-dependent mice thymic lym- phocytes, and RA patients PBL, and what was more that MT at a lower concontrations had a marked up-regulation on the above decreased lymphocytes proliferation.

结果表明，依赖组小鼠痛阈下降，跳跃次数增加，肛温降低，伴有胸腺细胞增殖能力的低下，Mor依赖小鼠的脑和血浆甲硫氨酸脑啡肽亦明显降低。ig MT（30、90 mg·〓×7d）能明显提高依赖性小鼠的痛阈，减少跳跃次数，恢复其肛温，阻止Mor对淋巴细胞功能的抑制，并能维持脑、血浆Met-Enk接近正常对照水平。

In the first experiment, C57BL/6J mice (6weeks, females) was pre-immunized with the normal rabbit IgG in rear footpads. Five days later, mice were received intravenously injection with 100, 150 and 200ml of NTS, respectively. Control mice were treated for normal rabbit serum.

诱发肾炎实验以6周龄雌鼠(C57BL/6J mice)为宿主，先在小鼠足底皮下注射正常兔子之IgG；5日后实验组分三组分别尾静脉注射肾毒血清NTS (100ml， 150ml， 200ml)，对照组则给予正常兔子血清。

Methods Mice were treated with three different doses of extract of ginger:high dose (9.3 mL·kg-1), middle dose (4.7 mL·kg-1),and low dose (2.3 mL·kg-1). All mice were irradiated once with 2.0 Gy X-ray. At the same time, the negative group (treated with vegetable oil only) and positive one (irradiated as well as extract of ginger groups after treated with vegetable oil) were set up. The changes of activities of enzymes in testes of mice were observed.

分别以高剂量（9.3 mL·kg-1）、中剂量（4.7 mL·kg-1）和低剂量（2.3 mL·kg-1）的生姜提取物给小鼠灌胃，以剂量为2.0 Gy的X射线一次性全身照射，24 h后观察不同组小鼠睾丸酶活性的变化，同时设阴性对照组和阳性对照组（给予植物油后与生姜提取物各实验组同时照射）。

Then we bred apoE〓 hemizygous transgenic mice to mice homozygous for double mutants amyloid precursor protein (APPV717F) transgene that develop the bigenic mice with age-dependent AD neuropathology.

双转基因鼠血脂水平、学习记忆能力随年龄增加的变化，老年斑的形成等正在检测中。

METHOD: ICR male mice of tumor model was made by inoculating with tumor cells (S180, EAC, Heps). Anti-tumor activity of brucine was evaluated by tumor inhibitory ratio and life prolonging rate of mice transplanted with tumor. RESULT: Brucine had significant restraining effect on transplanted tumor growth of mice.

用ICR小鼠接种S180、EAC、Heps瘤株造成相应的移植性荷瘤小鼠模型，考察马钱子碱对实体瘤模型(S180、Heps)小鼠的抑瘤率和对腹水瘤模型小鼠生命延长率以研究其抗肿瘤活性。

Methods: The Yifuqing granula was given to rabbit with febrilis caused by the TAB vaccine. The effects of the Yifuqing granula on the ache threshold value of Jimpy mice caused by Hot plate, on auricle inflammatory swelling of Jimpy mice caused by dimethyl benzene, on the bacterium of Jimpy mice in vivo, and on CPE caused by virus were observed.

观察一服清颗粒对三联菌苗所致兔发热的影响；采用小鼠热板法观察一服清颗粒对小鼠痛阈的影响；观察一服清颗粒对二甲苯所致小鼠耳廓炎性肿胀的影响；采用小鼠体内抑菌实验观察一服清颗粒对金葡菌感染小鼠死亡率的影响；采用细胞病变法观察一服清颗粒对病毒致细胞病变作用的影响。

Given the language of section 102(2), the Supreme Court's rejection of substantive review under NEPA seems unjustifiable in principle

按照第102条的规定，最高法院否决《国家环境政策法》所规定的实质性复审在原则上似乎是不正当的。

ObjectiveTo explore the effect of variable hip abduction orthosis on children spastic cerebral palsy.

目的探讨髋关节矫形器在儿童痉挛型脑性瘫痪康复中的作用。