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Methods and Results— To test this hypothesis, we generated transgenic mice with cardiac-specific oerexpression of DGK . There were no differences in heart size and heart weight between DGK -TG and wild-type littermate mice. The left entricular function was normal in DGK -TG mice.

方法和结果：为验证此假说，实验采用过表达心肌特异DGK的转基因小鼠，其心脏大小及重量与野生型同窝别小鼠无差异，左室功能亦正常。

Candida colonisation did not enhance oalbumin permeation in mast cell deficient W/W mice but did in congenic littermate control +/+ mice. Reconstitution of mast cells in W/W mice by transplantation of bone marrow deried mast cells restored the ability to increase oalbumin permeation in response to Candida colonisation.

念珠菌定植不加强肥大细胞缺陷W/W小鼠的蛋白通透性，而其同系同窝对照+/+小鼠则有加强，W/W小鼠通过骨髓肥大细胞移植重建肥大细胞功能可恢复念珠菌定植后对卵白蛋白通透性的增强作用。

Using ST1KO mice, we have demonstrated that early B lymphopoiesis is impaired in the absence of STAT1, including reduced numbers of pro-B, pre-B, immature-B, and mature-B cells in BM. Interestingly, B220+CD138+ cells of ST1KO mice are also significantly decreased in BM as apposed to WT mice.

在本论文中，我们发现STAT1基因剔除小鼠的早期B淋巴球发育，不论在pro-B， pre-B， immature-B，或mature-B时期皆有明显的缺陷；特别的是，STAT1基因剔除小鼠的骨髓细胞(B220+CD138+)则有明显减少的现象。

In order to develop a safe and effective immunoadjuvant to enhance the immunity and resistance of animals against infection, a novel CpG Oligodeoxynucleotides containing 11 CpG motifs was synthesized and inserted into the VR1012 plasmid, designated as VR1C. Then the recombinant VR1C was entrapped with Chitosan nanoparticles prepared by the method of ionic cross linkage, and employed to inject muscularly 3-weeks old Kunming mice; the blank VR1012 packed with CNP and saline were used to inoculate mice as the control groups. 28 days after inoculation, all mice were orally fed with 0.4ml 2x108CFU/ per mouse virulent hemorrhagic enteritis E. coli to challenge the resistance against infection.

为研制安全高效免疫调节剂增强动物免疫抗病能力，本实验设计合成含11个C pG基序的寡聚核苷酸，重组构建含CpG的VR1012质粒(VR1C)；制备壳聚糖纳米颗粒包裹重组质粒(CNP-VR1C)，肌注接种3周龄昆明小白鼠，设壳聚糖包裹空质粒和生理盐水对照组；接种后28天口服大肠杆菌攻毒观察小鼠天然免疫的变化和对强毒感染的抵抗力，Sandwich ELISA测定血清免疫球蛋白和白细胞介素含量。

Experiments were performed in three groups of mice,20 minutes later ,mice in control group were treated with 2ml PBS by ultrasonic nebulization for 20 minutes, mice in treatment group were treated with rhIL-10(10ng) by ultrasonic nebulization for 20 minutes.

结果：经DNA测序证实，克隆的hIL-10cDNA与文献报道的一致，应用ELISA方法检测证明在大肠杆菌中成功表达出了hIL-10，含量＞400pg/ml，检测其生物学活性与标准品无明显差异。

Lucidum spore were given orally to CsA immunosuppression model mice, and the phagocytic function of macrophage and neutrophile, total hemolytic complement, weight of immune organs of the experimental mice were detected on the 2nd and 20th days after the withdrawal. Results: In mice of high, middle, and low dosage subgroups of G.

用不同剂量赤灵芝孢子粉对环孢素A模型小鼠灌胃，于停药后第2、20天分别检测小鼠腹腔巨噬细胞和中性粒细胞的吞噬功能、免疫器官重量及血清总补体活性(CH50)。

to investigate the effect of epo on hepcidin mrna expression in normal mice,acute inflammatory mice and acd mice,the acute phase model and acd model of mouse was produced by subcutaneous injection of turpentine oil.

本研究探讨红细胞生成素在正常小鼠、急性炎症小鼠和慢性病性贫血小鼠模型中对hepcidin mrna表达的影响。

The levels of nitric oxide and interferon-γ in spleen cell cultured supcrnatants of 3 kinds of infected mice were measured by using ELISA kit and Griess reaction. Results: On the 3rd day after infection, the parasitemia of DBA/2 mice was much lower than that of BALB/c and C57BL/6 mice.

结果：感染第3d之后，DBA／2小鼠的虫体血症水平显著低于BALB／c和C57BL／6小鼠；将疟原虫寄生的红细胞和脂多糖或IFN-γ分别与3种感染第3d小鼠脾细胞共同培养后，DBA／2小鼠脾细胞培养上清中的IFN-γ和NO水平明显高于BALB／c和C57BL／6小鼠。

RESULT: The activity and drinking of mice who had proceeded bone marrow transplantation after 60Co total body homogeneous radiation was no significantly different with normal mice, but their pelage became grey, blood samples detection were also same with normal mice after five weeks of bone marrow transplantation, the proportion of GFP positive cells in bone marrow cells achieved 59.62±13.21% proved by laser confocal microscopy, all these evidence proved the bone marrow reconstitution had been finished in the recipients.

结果： 60Co全身均匀照射后进行骨髓细胞移植的骨髓移植组小鼠的活动与饮食与正常小鼠无明显差别，只是毛发渐变灰白，五周后其血常规与正常鼠相较无明显差异，流式细胞仪检测显示其骨髓细胞中GFP阳性细胞的比例也达到59.62±13.21%，提示骨髓重建成功。

Recombinant expression vector k14/c-myc-paav was constructed bearing the mouse c-Myc cDNA derived by the skin specific human keratin 14 promoter, then the linear vector was microinjected into the two pronucleus of the C57BL/6 fertilized eggs to produce transgenic mice.256 microinjected eggs were transferred, 6 of the foster mothers were pregnant and 44 adult mice were produced, two of them were positive transgenic mice confirmed by PCR and Southern blot analysis, transgenic rate was about 4%.

以CMV-PAAV载体为基础载体，以皮肤特异人K14（人角蛋白14）基因启动子替换原质粒中的CMV启动子后，在其多克隆位点区依次插入鼠c-Myc基因的cDNA序列和gfp基因的编码序列，构建了高效表达c-Myc基因的真核表达载体。通过双原核显微注射技术，将线性化的载体DNA注入到C57BL/6小鼠受精卵的两个原核中，然后将注射后状态良好的胚胎移植到代孕鼠的输卵管中，共移植了256枚受精卵，6只受体怀孕，最终获得44只成年小鼠。

"Yes, now you can give yourself airs," she said, you have got what you wanted.

"对了，您现在高兴了，"她说道，这是您所期待的。

Then the LORD said to me: Rebel Israel is inwardly more just than traitorous Judah.

上主于是对我说：＂失节的以色列比失信的犹大，更显得正义。