查询词典 methylation

N-methylmaleimide was prepared by using dimethyl sulfate as methylation reagent.The paper investigated the addition of N-methyl-3,4-dibromomaleimide and indolylmagnesium bromide,and then 2-bromo-3-(1H-indolyl-3-yl)-N-methylmaleimide and 3,4-bis(1H-indolyl-3-yl-)-N-methyl-maleimide were obtained.

对吲哚在溴乙烷和镁作用下生成吲哚溴化镁，而后与3，4－二溴－N－甲基马来酰亚胺的加成反应进行了研究，合成了2－溴－3－(1H－吲哚－3)－N－甲基马来酰亚胺，并对反应条件进行了改进，研究了反应温度和原料配比对反应的影响。

Methylation profiling also poses an important topic for study of embryonic stem cell and somatic cell cloning.

此外，研究甲基化概况也在胚胎干细胞及复制动物的研究上引发一些重要的研究主题。

In recent years, crystallographers have developed a series of method to improve the quality of protein crystals, such as crystal growth in metastable zone, influencing the kinetics process of protein crystal in special environment, obtaining high quality crystals by adding detergent and reductive methylation of proteins.

近年来人们从影响蛋白质结晶过程的各个因素出发，发展了一系列提高蛋白质晶体质量的方法，如在亚稳区生长蛋白质晶体、利用特殊环境影响蛋白质晶体生长的动力学过程、利用去垢剂提高蛋白质晶体质量和分子工程改造蛋白质分子提高晶体质量等。

Objective To detect the methylation levels of genomic DNA in patients with systemic lupus erythematosus.

目的：检测系统性红斑狼疮患者基因组DNA甲基化的水平，探讨其在SLE发病中的意义。

As we have knowen that,DNA methylation is associated with transcriptional silencing of tumor suppressors or other genes important for normal cellular function and plays an important role in the development of gastrointestinal tumor.

随着对DNA甲基化的分子机制的进一步认识，以甲基化为基础的标志在临床的应用，尤其是肿瘤的防治，展现了广阔的前景。

DNA CpG island methylation can result in the transcriptional inactivation of tumor suppressors genes, which facilitate tumor progression.

CpG岛甲基化可导致基因启动子的功能异常，引发基因转录的静息，最终导致功能蛋白的下调和缺失，从而促进肿瘤的发生和发展。

Krogan N J, Kim M, Tong A, et al Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase ||. Mol Cell Biol, 2003, 12(2):476-487[12] J Biol Chem.

表达基因转录起始下游的局限性H3-K9的三甲基化不在启动子高甲基化的区域，H3-K9的三甲基化耦合于RNA聚和酶II在沉默基因中具有一致性。

Reik W. Genomic imprinting. Imprinting with and without methylation. Curr Biol, 1994, 4(2):145-147.[4] Yoshioka H, Shirayolshi Y, 0shimura M.

PWS的临床症状主要有肌张力低下、身材矮小、外生殖器发育不良和精神发育迟缓等。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。