查询词典 methylation

To address this question in an unbiased and genome-wide manner, we developed a new method, methylation-specific digital karyotyping, and applied it to epithelial and myoepithelial cells, stromal fibroblasts from normal breast tissue, and in situ and invasive breast carcinomas.

为了能无偏向地并在基因组范围解答这个问题，我们开发了一种新的方法——甲基化特异性数字染色体组型，并将这一方法应用于上皮细胞和肌肉上皮细胞、正常乳腺组织来源的基质成纤维原细胞、原位及侵入性乳腺癌细胞。

With the inducing time prolonged, the amount of fusion protein increased, and the highest content amounted to 39. 14% of total protein. Different temperature (15℃, 25℃ and 37℃) could induce expression of fusion protein, and the higher inducing temperature was, the more total fusion protein and soluble fusion protein was produced. Most fusion protein was expressed in the cytoplasm and was soluble, a little of fusion protein was expressed in periplasm or expressed as inclusion bodies, and no fusion protein was found in culture. Furthermore, the results of in vitro enzymatic reaction suggested that the fusion protein could catalyze the methylation of theobromine.

随着诱导时间的延长，表达的融合蛋白产量逐渐增加，表达蛋白总量最高可达到菌体总蛋白的39.14％；在15℃、25℃和37℃三个不同的诱导温度下，均能诱导产生融合蛋白，而且产生的融合蛋白的总量及其可溶性部分所占比例均随诱导温度升高而增加；在菌体的各个部位中，融合蛋白主要在细胞质中以可溶的形式进行表达，有少量在外周质中表达或以包含体形式在细胞质中表达。

In order to find highly active pesticide, three series of 5--12-substituent-benzo phenanthridine derivatives were synthesized through the reaction of 2-methylbenzonitrile with dif-ferent aldehyde, and further dehydration with DDQ or N-methylation with NaH and CH3I, respectively.

为了寻找新的高活性农药，利用2-甲基苯甲腈与不同的醛反应，再通过2，3-二氯－5，6-二氰基－1，4-苯醌脱氢或NaH和CH3I氮甲基化，合成了3个系列共18个5-取代氨基－12-取代苯并菲啶衍生物，其中15个是未见文献报道的化合物。

A negative relationship was indicated between ERα expression and the promotor methylation in breast cancer.

乳腺癌组织ERα表达与启动子区甲基化之间呈显著负相关。

A negative relationship was indicated between ERα expression and the promotor methylation in breast cancer.

乳腺癌组织ERα表达与启动子区甲基化之间呈显著负相干。

The functions and interactions of DNA methylation regulating factors, the establishment, mantainace and removement mechanisms of DNA methylations are reviewed in this paper.

DNA转葡糖基酶有去甲基化活性从而减轻基因沉默。文章综述了以上植物DNA甲基化调控因子的生物学功能及其之间的相互作用和近年来的研究进展，以更好的理解DNA甲基化的建立、保持和去除的机制。

Based on the observation that mammalian cells appear to be dependent on methylation for activation, SAHH has recently been selected as an attractive specific target for design of agents for immunosuppression, antiviral, treatment of atherosclerosis and Alzheimer's disease.

鉴于SAHH在调节生物体转甲基化反应中的核心地位，它已被选择作为多种新药研发的重要靶点，包括免疫抑制剂、抗病毒药、防治动脉粥样硬化和阿尔茨海默病药物。

The pharmacokinetic parameters of scutellarin were significantly different in normal and model rats. The metabolic pathways of scutellarin was proposed to be dehydroxylation and methylation.

正常和模型大鼠体内灯盏乙素的药动学参数有显著性差异；灯盏乙素在大鼠血浆样品中的代谢主要是脱羟基和甲基化途径。

The specifical concentration of cholesterol could decrease the VECs genomic DNA methylation level.

一定浓度的胆固醇能降低血管内皮细胞中DNA甲基化水平。

The derivatives of the amino acids containing sulphur synthesizedfrom three sulphydry amino acids such as methione, cysteine and cystine play an important role on the methylation,sulphuration, detoxication and ,antioxidation and are very useful in pharmaceutic and food industry.

含硫氨基酸衍生物主要由三个常见的含硫氨基酸——蛋氨酸，半胱氨酸，胱氨酸衍生转化而来，可以在体内参与转甲基，转硫基等生化过程，同时也具有抗氧化，清除自由基等功能，在医药和食品中具有重要的应用价值。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。