查询词典 methylation

Methylation variations of artificial F4 and F10 generations of Raphanus sativus×Brassica alboglabra allopolyploid were examined with MSAP. The results showed that the methylation levels of F4, F10 were 30.61% and 33.10%, respectively.

以人工合成的萝卜－芥蓝异源四倍体的F4和F10世代为材料，用MSAP法检测2种材料DNA甲基化变异情况，以期为远缘杂交后不同世代间基因组DNA甲基化遗传和变异规律提供实验依据。

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

Methods Using a modified semi-nested methylation-specific PCR, the status of methylation of the p16 was investigated in bronchia rinse and whole blood DNA from 26 lung cancer patients.

方法利用半巢式甲基化特异性PCR技术，检测26例肺癌患者支气管灌洗液及相应全血中DNAp16基因的异常甲基化状态。

The relationship between molecular modification of erythromycin and NMR chemical shifts was summarized. It's noticeable that downfield of shifts of H-3 (△δ 0.2) after silylation and upfield of shifts (△δ-0.4) after methylation. No changes were observed after methylation.

分析总结了红霉素分子修饰与核磁共振化学位移变化之间的关系，并且发现大环上H-3硅烷化后由高场移至低场（△δ为0.2），甲基化后又由低场移至高场（△δ为-0.4），变化均较大；而且一旦甲基化后H-3化学位移在高场几乎不再变化。

The types of histone methyltransferases, the relationship between methylation of Lysine 9 of H3 and the formation of heterochromatin, gene regulation in euchromatin, and that with DNA methylation, were mainly introduced.

主要阐述了组蛋白甲基转移酶的类型，组蛋白H3中第9位赖氨酸甲基化与异染色质的形成、常染色体中基因表达的调控，以及与DNA甲基化之间的关系，说明了组蛋白甲基化与组蛋白乙酰化、磷酸化的相互关系，指出组蛋白甲基化对维持细胞各种状态的平衡起到极其重要的作用。

Methylation is negative correlation with genetic transcription , and the mechanism is probably as follows : directly interfere the combination of specific transcripton and recognition site of each promoter ; mediated transcription inhibition by change the construction of chromatin; induced gene silencing by combination of methylation site and transcription inhibition. P16 gene is also called multiple tumor supresser gene , which is the best easily to methylate in the anti-oncogenes. P16 gene locates in 9p21 of mankind-chromatosome , and it's total length is 8.5kb .

甲基化与基因转录呈负相关，其机制可能是[3]：直接干扰特异的转录子和各自启动子识别位点的结合；通过改变染色质结构，介导转录抑制；甲基化DNA位点直接与转录抑制子结合，诱导基因沉默。p16基因又称为多肿瘤抑制基因( multiple tumor suppressor 1 ，MTS1) [4] ，是肺癌中最易发生甲基化的抑癌基因，该基因位于人类染色体9p21上，全长8.5kb ，由两个内含子和三个外显子组成。

All date above showed that SDG714 was involved in heterochromatin stability and the mechanism of histone methylation controlling DNA methylation was conserved in monocot.

表明SDG714影响异染色质的功能和染色体的稳定性，H3K9组蛋白的甲基化控制DNA的甲基化这一特性，在水稻中同样具有保守性。

Objective: To investigate the clinical significance and character of methylation of the 5'CpG island of p 16 gene promotor in pancreatic cancer and the value of detecting methylation of the 5'CpG island of p16 gene promotor from pancreatic juice in the diagnosis of pancreatic cancer.

目的：探讨胰腺癌p16基因启动子区5'CpG岛甲基化改变的特点和其临床意义，以及胰液中p16基因甲基化检测对胰腺癌早期诊断的价值。

The method has the advantages of high analysis speed and high sensitivity, can detect micro-target DNA methylation, and can carry out the joint detection of the polygene methylation.

具有分析速度快、灵敏度高，能检测微量靶DNA甲基化，可同时进行多基因甲基化的联合检测。

Because of the reversibility of methylation, the drugs reducing the level of methylation become a new way to cure leukemia.

由于甲基化的可逆性，降低甲基化水平的药物就成了治疗白血病的新手段。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。