查询词典 methylation

However, mosaicism of both CGG repeatlength and methylation status exists in fragile X patients.

全突变经常是嵌合性的，甲基化现象也会嵌合发生。

The methylation status of P16INK4a and the expression of its protein may have no relationship with the different type of mycosis fungoides.

P16INK4a基因甲基化状态及蛋白的表达和蕈样肉芽肿的分型可能不具有相关性。

Ischemia injury of oligodendrocyte could make obstacle on methylation of myelin sheath alkali protein after cerebral ischemia.

维生素B12参与了髓鞘形成过程，在中枢神经系统白质损伤的恢复以及脑缺血后痴呆和锥体系病变的恢复方面显示了良好疗效。

Results The hyper-methylation rates of RASSF1A gene were 93.75%(15/16 cases) in NPCs and 0 in chronic nasopharyngitis.

结果 RASSF1A基因的高甲基化率在鼻咽癌组织中为93.75%(15/16)，在慢性鼻咽炎组织中为，两组病例的RASSF1A基因高甲基化率差别显著，P.005。

It is the result that in process of pathological changes induced by nitrosamine compounds, the genome methylation level were gradually fall, and then keep the steady statements.

结果在亚苄混合物诱导的小鼠食管癌变过程中，全基因组甲基化修饰是逐渐降低的，在达到一定程度后即保持一种稳态。

AIM: To detect the differentially expressed genes in the process of esophageal carcinoma induced by nitrosamine, and analyze the property of gene expression at different stages, especially the relationship between differentially expressed genes and DNA methylation.

摘要目的：通过基因芯片技术检测亚硝胺诱导食管癌变过程中，食管组织基因表达的差异，分析不同阶段基因表达的特点以及基因差异表达与DNA甲基化的相关性。

Noma de México and the Instituto Nacional de Cancerolog?a, Mexico, demonstrate, for the first time, that a combination of a DNA methylation and a histone deacetylase inhibitor, can reactivate the expression of more than a thousand genes in primary tumours of breast cancer patients.

在PLoS ONE开始的一期，来自墨西哥国家癌症研究所和国家Aut大学Investi gaciones Biomédicas研究所的Due馻s-Gonzalez博士领导研究组第一次证明DNA甲基化和组蛋白去乙酰化的抑制物联合可以使乳腺癌患者在初期肿瘤时超过一千个基因的表达失活

Noma de México and the Instituto Nacional de Cancerolog?a, Mexico, demonstrate, for the first time, that a combination of a DNA methylation and a histone deacetylase inhibitor, can reactiate the expression of more than a thousand genes in primary tumours of breast cancer patients.

在PLoS ONE开始的一期，来自墨西哥国家癌症研究所和国家Aut大学Inesti gaciones Biomédicas研究所的Due as-Gonzalez博士领导研究组第一次证明DNA甲基化和组蛋白去乙酰化的抑制物联合可以使乳腺癌患者在初期肿瘤时超过一千个基因的表达失活

Objective To detect the expression of CD70 in peripheral T lymphocytes of patients with systemic lupus erythematosus and the effect of azacitidine, an inhibitor of DNA methylation, on it. Methods Blood samples were obtained from 10 patients with active SLE （SLEDAI score ≥5）, 10 patients with nonactive SLE （SLEDAI score 5） and 10 normal human controls.

目的 通过研究共刺激分子CD70在SLE患者外周血T淋巴细胞的表达水平，以及DNA甲基化抑制剂氮杂胞苷对正常人外周血T淋巴细胞表达CD70分子的影响，探讨DNA甲基化在SLE患者外周血T淋巴细胞表达CD70分子中的调控作用。

Results The frequency of CD70+CD4+ lymphocytes was 14.55%± 5.49% in normal control group, 85.25%± 14.08% in active SLE group, 77.65%± 18.77% in nonactive SLE group, and 81.54%± 8.71% in methylation-inhibited group. Compared with the normal control group, a significant increase was observed in both the frequency of CD70+CD4+ lymphocytes （all P 0.01） and the expression of CD70 expression （all P 0.05） in other three groups.

结果 正常人外周血CD4+CD70+ T淋巴细胞阳性率为14.55%± 5.49%，活动期、非活动期SLE分别为85.25%± 14.08%和77.65%± 18.77%，甲基化抑制组为81.54%± 8.71%，与正常人对照组相比，活动期、非活动期SLE患者和甲基化抑制组CD70+CD4+ T淋巴细胞阳性率均明显升高（P 0.01），其外周血T淋巴细胞CD70 mRNA表达水平亦明显增加（P 0.05）；SLE患者外周血CD70+CD4+ T淋巴细胞阳性率与SLE疾病活动度呈显著正相关（r = 0.72，P 0.05）。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。