查询词典 methylating

To investigate the characteristics of arsenic methylating metabolism in population in coal-burning type arsenism endemic area and in control area, and to explore the difference between the two population.

目的 描述燃煤型砷中毒病区人群与非病区人群砷甲基化代谢的特征，比较两区人群砷甲基化代谢水平的差异。

Their observation suggests that methylating enzymes may travel along one face of the DNA molecule, placing multiple methyl groups at once.

他们的研究提示，甲基化酶可能延着DNA分子的一面移动，一次性添加多个甲基团。

Background and Objective: Epigenetic silencing of the DNA repair gene, O^6-methylguanine-DNA methyltransferase, is associated with the therapeutic response to methylating agents.

背景与目的：如何预测和克服肿瘤细胞对化疗药物的耐药性，实施个体化治疗是肿瘤化疗急需解决的问题。

The coated non-polymer was a liver-born methylating agent with active surface property.

包被SPIO的非聚合物材料是肝内的甲基化剂，具有活泼的表面活性。

Recent progress of dimethyl carbonate which acted as methylating reagent in methylation reaction s that took place on carbon, oxygen, nitrogen and sulfur atoms was reviewed.

综述了碳酸二甲酯作甲基化试剂在碳、氧、氮和硫原子上进行甲基化反应的研究进展，提出了今后研究工作的发展方向。

In addition,we described an intriguing property of TR3 to inhibit the methyltransferase activity of PRMT1 by targeting to the PRMT1 catalytic region,resulting in the loss of the ability of PRMT1 for methylating its substrates.

我们还进一步发现，TR3不能被PRMT1甲基化的原因是TR3通过和PRMT1的催化区域直接结合抑制了PRMT1的甲基转移酶活性。

On the discussion about mechanism of mutation of methylating, we explored thermodynamics and dynamic properties on base pairs, investigating the proton transfer on base pairs.

从甲基化对嘌呤碱基电荷的影响，到甲基化引起碱基配对的改变造成碱基配对的诱变等都作了较为详细的探讨；在对甲基化诱变的探讨中，我们进行了热力学和动力学方面的研究，同时对碱基之间的质子迁移的难易程度也作了探讨；并在充分考虑水分子存在的情况下研究了甲基化对碱基之间的氢键作用和堆积作用的影响。

And we also research the impact of methylating on hydrogen bond and stacked bond in base pairs under considering water molecules.

研究结果表明，烷基化之所以能造成碱基错配是它可使碱基的质子迁移或烯醇互变现象容易发生，改变原有原子的电荷分布或配对模式，同时碱基自身的互变异构体会跟烷基作用，致使互变异构体能够稳定存在，影响正常碱基配对，引起碱基诱变，造成生理疾病的发生。

The rusults show that methylating can make the proton transfering in base pairs easily happened, changing the distribution of charges or the mode of pairing.

研究结果还表明甲基化能改变碱基之间的相互作用力，从而改变DNA的稳定构型，造成DNA复制发生错误。

cDNA microarray was an effective and useful method to survey gene expression profiles in pancreatic carcinoma. MBD1、EDG1 and its hyper methylating modulation may play an important role in the pathogenesis of pancreatic cancer, among which the high expression of MBD1 in pancreatic cancer would be the key modulating point in the down regulation of multiple methylation related suppression genes transcription.

cDNA微列阵技术为胰腺癌相关基因表达谱的分析提供了有力的工具，MBD1、EDG1等基因过甲基化表达调控可能在胰腺癌发病机制中起着关键作用，而MBD1在胰腺癌中高表达可能是多个甲基化相关抑癌基因转录表达下降的关键调控点。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。