查询词典 methylated

The inhibitor for DNA methyltransferase, 5-azacytidine (5-azaC), can demethylate the methylated DNA and restore transcription of genes. High dose homocystine can mediat DNA methylation and suppress gene expression.

应用甲基转移酶抑制剂5-氮杂胞苷(5-azacytidine， 5-azaC)可以使甲基化的启动子去甲基化，启动基因重新转录；高浓度同型半胱氨酸(homocystine， Hcy)可以介导基因甲基化而抑制其表达。

Other methyl nucleophiles includingMeMgBr, MeCeCl2, MeTiCl3, Me3Al, Me3ZnMgCl, MeMnClwere tried, but in all these cases no detectable amount of exo-C8-methylated product was obtained. Although protecting C3-carbonyl as 1,3-dioxolanes could be achieved, the serious enolization of C8-carbonyl was still problematic. Converting C9-furan ring to α,β-butenolide did depress the enolization, but desired C8-methylation was completely replaced by migration of the double bond of the butenolide.

在本论文的早期阶段，主要着眼于解决二环[3.2.1]-C8-羰基加成甲基所遇到的C9-呋喃环差向异构化和C3与C8两个羰基之间化学选择性的问题：通过引入不同金属降低甲基试剂的碱性并没有取得甲基化的成功；通过不同的方法将C3-羰基掩蔽，但是C8-羰基的烯醇化依然无法抑制；虽然通过将呋喃环转化为α，β-不饱和-γ-丁内酯可以抑制烯醇化，但内酯环上的双键迁移又成了新的竞争反应。

Fluorescence in situ hybridization and immunofluorescence assay revealed that the DNA sequences associated with the heterochromatic knobs are highly divergent and heavily methylated compared with the sequences in the corresponding X chromosomal domains.

而通过NDA的分子原位杂交，专家在番木瓜的雄性区域发现了该区域有4个特异的异染色质疖，免疫荧光分析则揭示出这个区域与X染色体的相应区域发生了较大的分化，具有高度的甲基化。

The features of molecular structure of aromatics, resins and asphaltenes were investigated by ruthenium-ion-catalyzed oxidation, where involatile acid products were methylated with excess diazomethaneether and volatile acids were esterified with phenacyl bromide.

利用钌离子催化氧化方法对大港减压渣油芳香分、胶质和庚烷沥青质进行了选择性降解，通过GC、GC-MS等分析手段对降解反应产物中一元正构脂肪酸、α，ω-二元正构脂肪酸和苯二～六元羧酸的含量和分布分别进行了定量分析。

Result shows that the sulfur compounds in the diesel can react with iodomethane easily at room temperature, the most of sulfur compound derived into methylsulfonium salts; the homologue of benzothiophene get the higher conversion ratio and react selectivity than the homologue of dibenzothiophene. It is found that primarily sterically hindered alkylated DBT, for example, 4-or 4-, 6-DBT, is recalcitrant to be methylated.

结果表明：柴油中硫化物在室温条件下容易与碘甲烷发生甲基化反应，大部分硫化物转化为锍盐，总转化率超过80%，苯并噻吩类比二苯并噻吩类更易发生甲基衍生化反应，转化率也相应较高。

The complexity of the methylarginine mark is enhanced by the ability of this residue to be methylated in three different ways on the guanidino group: monomethylated, symmetrically dimethylated and asymmetrically dimethylated, each of which has potentially different functional consequences.

根据将S-腺苷甲硫氨酸(S-adenosylmethionine，AdoMet)上的甲基转移到精氨酸的胍基氮上产生甲基化的不同方式，最终可以分为三类：单甲基化、对称性双甲基化和非对称性双甲基化。

Pcr products were visualized under uv after agarose electrophresis. results: the hypermethylation of blu gene promoter was detected in all the 12 frozen tissue cases (100%) and 8 out of 35 paraffine embedded tissue cases (23%) by methylated primer and the hypermethylation of arf was observed in 1 of 20 frozen cases and 3 of 35 paraffine embedded cases.

结果：在12例鼻nk/t细胞淋巴瘤冰冻组织病例中，12例均有blu基因高度甲基化，仅1例有arf基因高度甲基化；35例石蜡组织病例中，blu基因高度甲基化8例，arf基因高度甲基化3例。

P16 gene is composed of two intervening sequences and three exons , and encodes p16 protein , which is the inhibiter of CDK4 and CDK6 . They can together prevent phosphorylation deactivation of pRB , and make the cell cycle blocked in G1 stage. P16 gene promoter region has a great of CpG islands , which can be methylated when some adverse factor appears , and so the genetic transcription of p16 can be inhibited , which leads to gene silencing, cell paraplasm, and tumor generate.

抑癌基因p16编码蛋白P16 ，是细胞周期蛋白CDK4和CDK6抑制剂，它阻止pRB磷酸化失活，使细胞周期阻滞于G1期。P16基因启动子区域富含CpG岛，当受到各种有害因素影响时，容易发生甲基化，从而抑制P16基因转录，导致基因沉默，细胞异常增生，导致肿瘤的发生[5]。

However, no significant differences were shown between the cell cultures treated with pentavalent methylated arsenicals and control cultures in reduced rates of alamarBlue and morphological observation at the highest levels of exposure.

另一方面，暴露最高1 000 μmol/L 5价甲基砷和二甲基砷的星型胶质细胞的AlamarBlue还原力及细胞形态与对照组比较未见明显差异。

It is well known that isorhamnetin is used in clinic to cure coronary artery diseases, rhamnetin is used as a fine anti-inflammatory, and these medicines are just such methylated products.

本课题通过对槲皮素甲基化的研究，力求得到五个不同位置的甲基化反应产物。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。