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Increasing number of chemicals have been found to be estrogenic or possessing other endocrine disruptive effects. Among them are some organochlorine pesticides and other organochlorine chemicals, such as DDT and its metabolite p, p'-DDE, kepone, toxaphene, dieldrin, and PCBs, dioxins, and furans.

现在已经有越来越多的化学物被发现具有雌激素样作用或其它内分泌干扰作用，其中有相当一部分为有机氯农药或其他有机氯化合物，如滴滴涕及其代谢产物p，p'-DDE、开蓬、毒杀芬、狄氏剂以及多氯联苯、二恶英和呋喃类等。

By the affinity chromatography,fusion protein is purificated. The antiserum of chicken and rabbit were prepared with the fusion protein and Ghrelin-KLH.With active immunity and passive immunity,confirmed that Ghrelin of chicken have no obviously impact on ultimum metabolite,plasma Insulin,glucagons, T_3 and T_4.It entrances plasma GH,but inhibit food intake and increase of fat and body weight.These conclusion are obviously different from the mammal.

以纯化的融合蛋白和人工合成的Ghrelin-KLH为抗原，制备了鸡、兔抗血清：通过主动免疫、被动免疫中和实验证实禽类Ghrelin对鸡血浆中代谢产物、胰岛素、胰高血糖素、甲状腺素浓度没有明显的影响，对GH的分泌有促进作用，但与哺乳动物中不同，Ghrelin抑制鸡的脂重、体重的增加，抑制鸡的摄食。

for the determination of the asiaticoside metabolite asiatic acid and ursolic acid was developed.

建立大鼠血浆积雪甙代谢产物积雪酸的气相色谱质谱检测方法。

Therefore, we suppose that in the tissues where ERβwas distributed, SECO may exert anticancer bioactivity by its metabolite ENL.

因此，在ERβ分布较多的器官中，SECO发挥功效的途径之一可能是通过代谢产物ENL来实现的。

Camptothecin is an important secondary metabolite in Camptotheca acuminata, native deciduous tree of south China.

喜树碱是我国特有树种―喜树中所含的重要次生代谢产物。

We conclude that PGI2 is the major AA metabolite in lean coronaries, and AA-mediated BK channel actiation is impaired in ZDF coronaries due to reduced PGIS actiity.

由此，我们得出结论：在瘦鼠的冠脉中，前列环素是花生四烯酸主要的代谢产物，而在zdf老鼠中，由于前列腺素合酶的活性的下降，花生四烯酸介导的BK通道的活化作用被削弱了。

BP binds to AhR and subsequent translocates to the nucleus to activate the downstream gene expression, such as CYP1A1 and CYP1B1, to metabolite BP to benzopyrene-7,8- dihydrodiol-9,10-epoxide.

此外，过去研究文献指出苯芘的代谢活化是透过多环芳香烃受体而去启动下游代谢酵素CYP1A1、CYP1B1的基因转录活化，将其代谢成为benzopyrene-7，8- dihydrodiol-9，10-epoxide。

. Conclusions:(1) AA-Ⅰ could induce apoptosis of HK-2 and the secretion of FN and TGF-β1 at a range of concentrations. Analysis of their time course and the blocking test indicate that those effects of AA-Ⅰ are partly mediated by TGF-β1.(2) AL-Ⅰ as one metabolite of AA-Ⅰ could induce the direct injury of HK-2, which potency was higher than AA-Ⅰ.

(1)在一定浓度范围内AA-Ⅰ能够导致肾小管上皮细胞凋亡、并诱导FN和TGF-β1分泌，上述事件发生的时相关系分析及抗TGF-β1中和抗体阻断试验结果表明，AA-Ⅰ导致肾小管上皮细胞损伤的作用可能是由TGF-β1所介导的。

Objective:A method for determination of the TTNPB ethyl ester and its metabolite in plasma was developed.

药物分析杂志000212摘要目的：TTNPB酸乙酯及其代谢物TTNPB同属维甲酸类药物，是治疗银屑病的有效药物。

Within natural disposition cortisol treats as the CYP3A4 active with 6 beta -hydroxycortisol in the urine proportion target; Within fresh metabolite 5-MDMT and bufotenine treat as the CYP2D6 active target in the urine proportion the research not to become Yang A mainly because LC/MS/MS to be unable to decide on in the urine 5-MDMT and 6 beta -hydroxycortisol..

以内生性cortisol与6β-hydroxycortisol在尿液中的比例当作CYP3A4活性的指标；以内生代谢物5-MDMT与bufotenine在尿液中的比例当作CYP2D6活性的指标的研究均未成功，主要因LC/MS/MS无法定出尿中5-MDMT及6β-hydroxycortisol。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。