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shuanggen cephalocathartic granule can significantly improve learing and memory ability of rat model of vd, the mechanisms might be related with the reduction of the expression of icam-1 on cmecs.

双根清脑颗粒可改善vd模型大鼠的学习与记忆的功能,其机制与下调vd模型大鼠脑微血管内皮细胞icam-1表达有关。

Centrophenoxine combined with point thread embedding protects the nerve cells in the dentale gyrus area of the hippocampus better and improves the learning and memory of the VD model rats more effectively.

在2006年3~8月采用药物和埋线结合的方法,用盐酸甲氯芬酯联合穴位埋线治疗VD大鼠,观察该方法对VD大鼠海马神经细胞及学习记忆的影响,以期为中西医结合治疗VD提供实验依据。

centrophenoxine combined with point thread embedding protects the nerve cells in the dentale gyrus area of the hippocampus better and improves the learning and memory of the vd model rats more effectively.

盐酸甲氯芬酯联合穴位埋线能保护vd大鼠海马神经细胞,明显提高其学习记忆能力。

Methods: Random single blind method was used in clinical study to observe the clinical effect of YZD and compared with that of Ritalin. The dysmnesia model animal was used to observe the effect of YZD on learning memory function and cerebral monoamine neurotransmitter content.

临床研究采用单盲法随机观察益智丹与利他林的临床疗效;实验研究制作记忆障碍模型,观察益智丹对小鼠学习记忆功能和对小鼠脑组织单胺类神经递质含量的影响。

Results Both of MED and optimized MED improved the memory results about latent time and error frequency of dysmnesia mouse models significantly comparing with model control group (P nbsp; 0.01), and the improvement of optimized MED was more noticeable than that of MED (P nbsp; 0.01). Comparing with control group, optimized MED up-regulated the expression of CREB gene significantly (P nbsp; 0.01), and the effect had a dose response relationship.

结果:强记汤及天然脑活素水煎液对动物记忆障碍模型小鼠记忆成绩中的潜伏时间、错误次数与模型对照组比较均有统计学意义(P 0.01);而且天然脑活素的改善效果明显优于原方(P 0.01);不同剂量天然脑活素水煎液 CREB 表达水平与对照组比较有统计学意义(P 0.01),且有剂量反应关系。

Objective:to compare the effects between seed stem and commercial rhizoma gastrodia on memory dysmnesia induced by scopolamine in rat .methods: a month before the scopolamine administration, seed stem and commercial rhizoma gastrodia were given to two groups of young rats with scopolamine–induced dysmnesia model, incubation period of findingplatform were measured by means of morris watter-maze.

目的比较天麻种麻与天麻商品麻改善东莨菪碱诱发的记忆障碍的疗效。方法用天麻种麻,商品麻灌胃饲养幼鼠一个月,然后用东莨菪碱诱发大鼠造记忆获得性障碍模型,通过morris水迷宫测试大鼠寻找平台的潜伏期。

Results both of med and optimized med improved the memory results about latent time and error frequency of dysmnesia mouse models significantly comparing with model control group (p nbsp; 0.01), and the improvement of optimized med was more noticeable than that of med (p nbsp; 0.01). comparing with control group, optimized med up-regulated the expression of creb gene significantly (p nbsp; 0.01), and the effect had a dose response relationship.

中药古方强记汤及天然脑活素对实验动物被动回避反应能力的记忆获得、记忆保持及记忆再现均有的改善作用,能显著增加在 b104 cns 神经元细胞中 creb 基因的表达。

Objective To explore into the probable mechanism of Alzheimer's diseaseby the acupuncture treatment combined with DGSYS of TCM.Methods Three kinds of model rats with dysmnesia which were made by injected into drug of scopolamine or NaNo 2 in the abdomen separately and injured at the hippocampal CA 1 in brian by drug of quinolinic acid treated by single acupuncture or acupuncture combined with DGSYS of TCM or DGSYS of TCM were observed separately,to compare different influence on dysfunctions of acuquisition and consoli-dation of memory induced by drugs and injure with nimodipineor the normal rats.

通过腹腔注射药物东莨菪碱或亚硝酸钠,或者用奎宁酸损毁大脑海马CA 1 区诱发大鼠发生记忆力障碍,造成不同类型的大鼠&痴呆&模型,对照性观察针刺、针刺加DGSYS、DGSYS及NM对记忆障碍功能的影响和与记忆相关实验指标参数的变化。

Li Zhongren,Shen Meihong,Mu Yanyun,et al.Nanjing University of TCM,Jiangsu210029. Objective To explore into the probable mechanism of Alzheimer's diseaseby the acupuncture treatment combined with DGSYS of TCM.Methods Three kinds of model rats with dysmnesia which were made by injected into drug of scopolamine or NaNo 2 in the abdomen separately and injured at the hippocampal CA 1 in brian by drug of quinolinic acid treated by single acupuncture or acupuncture combined with DGSYS of TCM or DGSYS of TCM were observed separately,to compare different influence on dysfunctions of acuquisition and consoli-dation of memory induced by drugs and injure with nimodipineor the normal rats.

目的 探索临床针刺加当归芍药散治疗阿尔采默氏症的可能机理方法通过腹腔注射药物东莨菪碱或亚硝酸钠,或者用奎宁酸损毁脑海马CA 1 区诱发大鼠发生记忆力障碍,造成不同类型的大鼠&痴呆&模型,对照性观察针刺、针刺加DGSYS、DGSYS及NM对记忆障碍功能的影响和与记忆相关实验指标参的变化。

Shenshu-geshu-baihui electropuncture could improve and increase the learning and memory ability of model animal,and its curative effect was better than Hydergine.

电针肾俞、膈俞、百会穴对模型动物学习与记忆能力下降有改善和提高作用,疗效优于喜德镇。

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