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This is a retrospective analysis of 194 patients with primary malignant brain tumor, who registered between January 1, 1970 and December 31, 1979 in cancer registration, Cancer Therapy Center, Veterans General Hospital, Taipei, Taiwan, R.O.C. There were 36 cases of glioblastoma multiforme, 86 cases of malignant astrocytoma (grade Ⅲ and a few grade Ⅱ), 22 of medulloblastoma, 12 of oligodendroglioma, 11 of ependymoma or ependymoblastoma and 27 cases of other types. There were 141 male cases with ages ranging from ito 81 years with a mean of 33.3±19.3 and median of 34 years.

自1970年1月至1979年12月台北荣民总医院癌病治疗中心癌病登记组共登记了194例原发恶性脑瘤其中多形神经胶母细胞瘤有36例,第二级及第三级星细胞瘤有86例,神经管胚细胞瘤有22例,间胶质母细胞瘤有12例,室管膜瘤或室管膜胚细胞瘤(ependy-moblastoma)有11例,其他有27例。

Based on relative literatures,this part has included five resesearch aspects as below.1 Fifteen compounds were isolated and purified by extraction,column chromatography,and their structures were determined on the basis of spectral analysis: acteoside(Ⅰ-1),isoacteoside(Ⅰ-2),crenatoside(Ⅰ-3),cistanoside F(Ⅰ-4),sinapoyl-4-O-β-D-glucoside(Ⅰ-5),adenosine(Ⅰ-6),β-siterol(Ⅰ-7),oleanic acid(Ⅰ-8), succinic acid(Ⅰ-9),caffeic acid(Ⅰ-10),protocatechuic aldehyde(Ⅰ-11),p-hydro xybenzyl alcohol(Ⅰ-12),β-daucosterol(Ⅰ-13),D-galacitol(Ⅰ-14),D-mannitol(Ⅰ-15).Ⅰ-4~15 were obtained from this plant for the first time,andⅠ-6,7,9,and 13 were isolated from Orobanche genus for the first time.2 The scavenging test of DPPH showed that most compounds have comparative antioxidant activity as L-ascorbic acid and part of them show better activity such as the O.coerulescens extract and phenylethanoid glycosides.Acteoside showed potent free radical scavenging effects with a median inhibition concentration of 25.6μg/ml.3 The anti-HBV activities of acteoside,isoacteoside and crenatoside were measured,and all of them showed suppressive activity on the expression of HBsAg and HBeAg in the HepG2.2.15 cell line.

本论文在文献调研基础上对紫花列当化学成分及生物活性进行了研究,并从免疫抗病毒角度探讨紫花列当中特征性成分类叶升麻苷的肝保护作用及其机制。1采用大孔树脂、硅胶和Sephadex LH-20等色谱技术对紫花列当进行系统的植物化学研究,从中分离得到19个化合物,利用UV和NMR等波谱手段及理化性质鉴定了其中的15个化合物,分别为类叶升麻苷(Ⅰ-1)、异类叶升麻苷(Ⅰ-2)、crenatoside(Ⅰ-3)、cistanoside F(Ⅰ-4)、sinapoyl-4-O-β-D-glucoside(Ⅰ-5)、腺苷(Ⅰ-6)、β-谷甾醇(Ⅰ-7)、齐墩果酸(Ⅰ-8)、琥珀酸(Ⅰ-9)、咖啡酸(Ⅰ-10)、原儿茶醛(Ⅰ-11)、对羟甲基苯甲酸(Ⅰ-12)、β-胡萝卜苷(Ⅰ-13)、D-半乳糖醇(Ⅰ-14)和甘露醇(Ⅰ-15除化合物Ⅰ-1、Ⅰ-2和Ⅰ-3外,其余化合物均为首次从该植物中分离得到。2)通过大孔树脂富集该药材有效部位苯乙醇总苷,并采用HPLC测得其所含特征性成分类叶升麻苷的含量可达80%以上。3DPPH自由基清除试验显示紫花列当提取物及其所含的苯乙醇苷类化合物均具有较好的抗氧化能力,其清除DPPH自由基能力接近于抗坏血酸。4采用卡介苗整体致敏、脂多糖离体攻击构建大鼠原代肝细胞免疫性损伤模型,在体外观察类叶升麻苷的保肝作用。

Mean TRACP activity was 3.25 +/- 0.59 U/L in control subjects. Median TRACP activity was significantly greater in patients with HPT (11.97 +/- 8.92 U/L) than those with other types of renal osteodystrophy (ROD; 2.17 +/- 0.61 U/L).

控制组的TRACP活性为 3.25+/- 0.59 U/ L.6个HPT患者的TRACP活性的平均值明显升高(11.97+/- 8.92 U/L)超过其他类型的肾骨发育不良的患者(ROD; 2.17+/- 0.61 U/L)。

Knee anterior median incision and medial patellar approach was applied, and anterior and posterior cruciate ligaments were excised during the surgery, osteophyma and corpus liberum of posterior articular capsule were cleared.

采用膝前正中切口和内侧髌旁入路,术中切除前后交叉韧带,清理后关节囊骨赘生物及游离体。

PRL-LIR positive perikarya were mainly seen in nucleus suprachiasmaticus, nucleus paraventricularis preopticus, nucleus supraopticus, nucleus hypothalamus paraventricularis, nucleus periventricularis arcuatus and nucleus accumbens. PRL-LIR fibers and their terminals were detected in paleostriatum and median eminence.

结果,PRL阳性胞体主要分布在视交叉上核、视前室旁核、视上核、下丘脑室旁核、弓状核和伏隔核,旧纹状体、正中隆起存在大量阳性纤维末梢,在侧脑室腹侧的室管膜和脑基底神经胶质板上也存在PRL阳性神经元。

The median overall survival durations in patients who received a curative approach ranged from 3 to 14 months and from 1 to 14 months in patients treated palliatively.

接受治疗的患者中位整体生存时间为3-14个月,而接受姑息治疗的患者中位生存时间是1-14个月。

OBJECTIVE To study the compression factor and clinical manifestation of the compression of the palmar cutaneous branch of the median nerve.

目的 介绍腕部正中神经掌皮支卡压综合征的临床表现,提高对该病的认识水平和治疗效果。

METHODS:(1)The bile-pancreatic ducts of rats were ligated,the catheters were inserted into right jugular vein and jejunum and the acute pancreatitis model was established.Forty pancreatitic rats were divided into four groups and were given simple parenteral nutrition(PN,n=10),early enteral nutrition(EEN,n=10), median enteral nutrition(MEN,n=10),and late enteral nutrition(LEN,n=10) respectively.

(1)结扎大鼠胆胰管,经右颈静脉及空肠插管建立大鼠急性胰腺炎营养支持模型。40只急性胰腺炎大鼠分别给予:单纯肠外营养(PN组,n=10),早期肠内营养(EEN组,n=10),中期肠内营养(MEN组,n=10),晚期肠内营养(LEN组,n=10)。

Distant metastases to the lungs (n=4), pleura (n=2), brain (n=3), and peritoneum (n=1), and paraaortic, paratracheal, and mediastinal LNs (n=2) were observed. Six of 9 patients (66%) died from tumor dissemination, all with a median overall survival of 4.3 years (range: 1 to 9 y).

此外,远处转移情况如下:肺(4例),胸膜(2例),脑(3例),腹膜(1例),主动脉旁、气管旁和纵膈淋巴结(2例)。6例(66%)死于肿瘤播散,其总体中位生存时间为4.3年(范围:1至9年)。

In this observational study, 65 children were treated with SLIT with a build-up phase of 11 days, culminating in a peak dose of 300 IR, and followed by a maintenance phase of 300 IR three times weekly. There were 51 boys and 14 girls; age range was 38 to 80 months (median age, 60 months). Allergens used were house dust mites in 42 patients, grass pollen in 11, olive pollen in five, Parietaria pollen in four, and cypress pollen in three patients. Adverse reactions and changes in the treatment schedule were compared in children aged 38 to 60 months vs those aged 61 to 80 months.

在这项观察性试验中,65位接受SLIT的儿童在11天的适应期后,将剂量逐渐调整到最高300 IR,接著以每周3次,每次300 IR的剂量持续接受治疗;试验中包括51位男童与14位女孩,年龄介于38至80个月(平均年龄为60个月);其中有42位病患以尘蹒、11位以花粉、5位以橄榄花粉、4位以墙草、3位以丝柏作为过敏原;年龄介于38至60个月的儿童,与61至80个月的儿童分成两组比较不良反应发生机率与治疗疗程的改变。

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