查询词典 mechanistically

Various classes of organic chemicals and diverse molecular structures often indicate complexity and multiplicity of toxic modes of action. Thus developing QSARs that are both mechanistically significant and highly predictive for diverse classes of chemicals that involved multiple or mixed mechanisms of toxic action will be advantageous and preferable.

有机污染物的种类多种多样，毒性机制也复杂多样，因此发展既能够准确预测包括多种作用机制的化合物的毒性，又具有明确物理意义的理想QSAR模型是结构活性关系技术发展的必然方向。

Mechanistically, CYR61 enhanced bmp-2 mRNA and protein expression in time- and dose-dependent manners, and osteoblast migration, proliferation, and differentiation abilities were significantly inhibited by BMP-2 neutralizing antibody.

实验结果发现，将CYR61重组蛋白处理造骨细胞，观察到随著CYR61处理浓度增加，可以促进造骨细胞的增生、移动；随著处理时间的延长可以促使细胞矿物质化。

These results define the atrial antiarrhythmic profile of a mechanistically noel antiarrhythmic drug and suggest that gap junction dysfunction may be more important in ischemic AF than in ATP remodeling or congestie heart failure substrates.

这些结果明确了这种新型抗心律失常药物的心房抗心律失常的特点，提示与快速心房起搏和充血性心力衰竭这两种房颤病理基础相比，缝隙连接功能失调可能在缺血性房颤中发挥更为重要的作用。

Mechanistically, the photocatalytic processes are based on the electron transfer from a excited dyes to the conduction band of TiO〓 semiconductor and subsequent some reactions such as the further reaction of injected electrons with adsorbed oxygen and complicated decomposition processes of dye cationic radicals to lead to dye degradation or mineralization, which offers a feasibility of utilizing inexpensive visible light or most part of solar spectra to treat dye pollutants.

其光催化过程的机理为：染料在可见光下被激发，电子从激发态染料传输到TiO〓半导体的导带，随后发生一系列的反应，如注入的电子与吸附的氧反应以及染料正碳自由基复杂的分解反应导致了染料的降解和矿化，这就为利用廉价的可见光或太阳光中的大部分可见光谱来处理染料污染物提供了可能。

Furthermore, MSC p43 depletion in mice caused disorganization of the axonal NF network. Mechanistically, MSC p43 is required for maintaining normal phosphorylation levels of NFs.

进一步观察发现，MSC p43 蛋白参与神经元轴突发育过程中所必需的 neurofilament 蛋白磷酸化正常水平的维持。

Because transient increases in choroidal thickness are followed by a prolonged decrease in synthesis of extracellular matrix molecules and a slowing of ocular elongation, and attempts to decouple the choroidal and scleral changes have largely failed, it seems that the thickening of the choroid may be mechanistically linked to the scleral synthesis of macromolecules, and thus may play an important role in the homeostatic control of eye growth, and, consequently, in the etiology of myopia and hyperopia.

由于细胞外基质分子合成持续减少以及眼轴变长减缓，脉络膜厚度瞬间增加，对脉络膜和巩膜变化的缓慢调节彻底失败，脉络膜增厚可能与巩膜合成大分子机械性联系在一起，因此它可能在眼生长稳态的控制方面发挥了重要作用，而且，也可能是近视和远视的病因。

Mechanistically, expression of a molecule known as P-selectin by the platelets was crucial for mediating the platelet-neutrophil interaction, which induced platelets to produce proinflammatory factors such as TXA2. The authors therefore suggest that disrupting the platelet-neutrophil interaction or blocking the proinflammatory factors produced as a result of this interaction might provide new therapeutic targets for the treatment of individuals with ALI.

具体来说，体现在分子水平上就是由血小板产生的血小板蛋白对于调解血小板和中性粒细胞交互影响起着关键作用，它能够诱导血小板产生致炎因素如血栓素A2等，该文作者因此认为，或许破坏血小板与中性粒细胞间的相互作用或者阻断相互作用所产生的致炎因素可以提供一种新的方法用于治疗急性肺损伤。

In experimental animals, exposure to a common herbicide, rotenone, induces features of Parkinsonism; mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mitochondrial complex Ⅰ.

例如，Greenamyre和他的同事在2000年报道了经大鼠颈静脉慢性灌流鱼藤酮复制了帕金森病的主要特征，包括选择性黑质纹状体多巴胺系统变性，Lewy小体样细胞浆包涵体形成和一些行为变化，例如运动减少和僵直等。从发病机制上考虑，鱼藤酮诱导的多巴胺神经通路损伤被认为是由鱼藤酮抑制线粒体复合体Ⅰ活性引起的。

With it, simple, mechanistically significant and highly predictive QSAR models were developed. These QSARs successfully model and predict the short-term phytotoxicity of substituted phenols involved both polar narcosis and bio-reactivity, the growth inhibition toxicity to Saccharomyces cerevisiae of substituted nitrobenzenes with mixed mechanisms of toxic action based on electrophilicity and the growth inhibition toxicity to Saccharomyces cerevisiae of large set of substituted benzenes with complex molecular structures and multiple mechanisms of action.

应用响应曲面分析方法建立了形式简单、意义明确并且具有高度预测性的QSAR模型，成功地预测了具有多种毒性机制的取代苯酚对高等植物的短期生长抑制毒性、具有多种亲电反应性机制的取代硝基苯对酿酒酵母菌生长抑制的反应性毒性以及结构复杂、机制多样的78种取代苯衍生物对酿酒酵母菌生长抑制毒性。

Mechanistically, the irradiation was found to alter the salient toughening mechanisms, manifest by the progressive elimination of the bone's capacity for plastic deformation which restricts the intrinsic toughening from the formation "plastic zones" around crack-like defects. Deep-ultraviolet Raman spectroscopy indicated that this behavior could be related to degradation in the collagen integrity.

机械性能方面，放射能明显的改变骨的韧性，骨的塑性形变能力被进一步降低，在破裂样损害周围形成&塑性区&，深紫外线拉曼光谱检测显示，这种现象和胶原完整性的降解有关。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。