查询词典 marrow

Bjective In this paper,we studied the effect of the low-frequency time-varying magnetic on the micronuclear rate in polychromatic erythrocytes of the mouse bone marrow.

目的：研究低频交变磁场对小鼠骨髓嗜多染红细胞微核率的影响。

MATERIAL AND METHODS: The micronuclear test in polychromatic erythrocytesof bone marrow and the sperm abnormality test were applyed in mice model.

材料与方法：小鼠骨髓嗜多染红细胞微核实验和小鼠精子畸变分析。

After the low-frequency time-varying magnetic of 10mT and 15mT acting on mice,the micronuclear rate of mouse bone marrow was determined.

用强度为10mT和15mT的低频交变磁场作用于小鼠后，检测其骨髓嗜多染红细胞微核率。

The micronuclear frequencies of fetal liver blood were 2.67, 3.33 and 4‰ in treatment group, given intraperitoneally combined NET-OEN at doses of 10, 50 and 100mg/kg, respectively. However, the micronuclear frequencies of bone marrow erythroblasts and fetal liver blood in control group were 1.8～3‰.

作者采用微核试验观察了复方庚炔诺酮对小鼠活体骨髓多染性红细胞及胎肝血微核率的影响，检测其有无潜在的致突变作用，从而为评价复方庚炔诺酮的安全性提供依据。

compound bio-flavine;Ames tests;rat marrow osteocyte micronuclear tests;rat sperm deformation tests

复方生物黄酮；Ames实验；小鼠骨髓细胞微核实验；小鼠精子畸形实验

Results The micronuclear rate in medium dosage group and high dosage group were significantly higher than that of control group(P＜0.01). The ratio of sperm malformation in middle group and high group were higher than those of controls (P＜0.01).The ratio of sperm malformation increased in dose-dependent manner with dose, a dose-response relationship was found. Conclusion The DBP contamination presents the positive results under the certain dosage to the mouse marrow micronucleus experiment and the spermatozoon abnormal experiment.

结果 中、高剂量组微核率与阴性对照组相比明显升高(P＜0.05)，且各剂量组微核率随染毒浓度的增加而升高，呈现剂量-反应关系(r=0.937，P＜0.01)；中、高剂量组精子畸形率与阴性对照组比较差异有统计学意义(P＜0.05)，且各剂量组精子畸形率随染毒浓度的增加而升高，呈剂量-反应关系(r=0.904，P＜0.01)，畸形精子中以无钩为最多，其次是香蕉形、尾折叠、双头，分别为4.5%、3.09%和1.32%，结论 DBP染毒在一定剂量下对小鼠骨髓微核试验和精子畸形试验呈现阳性结果。

The microkemel and sperm cell abnomalities were analyzed. Results The micronuclear rate in medium dosage group and high dosage group were significantly higher than that of control group(P＜0.01). The ratio of sperm malformation in middle group and high group were higher than those of controls (P＜0.01).The ratio of sperm malformation increased in dose-dependent manner with dose, a dose-response relationship was found. Conclusion The DBP contamination presents the positive results under the certain dosage to the mouse marrow micronucleus experiment and the spermatozoon abnormal experiment.

结果 中、高剂量组微核率与阴性对照组相比明显升高(P＜0.05)，且各剂量组微核率随染毒浓度的增加而升高，呈现剂量-反应关系(r=0.937，P＜0.01)；中、高剂量组精子畸形率与阴性对照组比较差异有统计学意义(P＜0.05)，且各剂量组精子畸形率随染毒浓度的增加而升高，呈剂量-反应关系(r=0.904，P＜0.01)，畸形精子中以无钩为最多，其次是香蕉形、尾折叠、双头，分别为4.5%、3.09%和1.32%，结论 DBP染毒在一定剂量下对小鼠骨髓微核试验和精子畸形试验呈现阳性结果。

The bone marrow smear of blood diseases in first visit was observed with microscopically.

用光镜观察初次确诊的518例血液病患者骨髓涂片。

2B8a was weakly reactive to neutrophils (23.72%) and negative for T cells, NK, DC, RBC and Plt. The antibody reacted to all 3 marrow CD34+ cells with an average positive rate of 39.33% while it was negative for G-CSF-mobilized CD34+ peripheral blood stem/progenitor cells (PBSC, 1.25%). Cell line analysis showed that the antibody notably reacted to three out of 4 cell lines (Raji, SMS-SB, Nalm-6 and Nall-1) with the positive rates of 98.78%, 98.61%, 94.93% respectively and weakly to one of them with 5.68% in B lineage cell lines and monoblastic cell line (U937, 67.78%) while it was only weakly positive or negative for other myeloid leukemia cell lines including Meg01 (33.40%), HL-60 (29.70%),K562 (28.19%), KG1a (16.23 %) and HEL92.1.7 (8.02%). Among 4 T lineage leukemia,5 neuroblastoma and 1 colon cancer cell lines tested, only Molt-3 was found weakly positive (31.40%) for 2B8a, while the remaining 3 T cell lines (Molt4, JM and CCRF-CEM), 5 neuroblastoma cell lines (LA-N1, KCNR, BE, SK-N-SH, SK-N-AS) and the colon cancer cell line (HR8348) tested were negative.

结果表明： 2B8a抗原在外周血B细胞上表达（3/3例，平均阳性细胞数为26.29 ％），而在T淋巴细胞和NK细胞上不表达（0/3例）；在粒细胞和单核细胞上阳性表达均为2/3例，平均阳性细胞数分别是23.72 ％和59.84 ％；在DC细胞、红细胞和血小板上均不表达（0/3例）。2B8a抗原在骨髓CD34＋细胞上的阳性表达是3/3例，平均阳性细胞数39.33 ％，而在G-CSF动员的外周血CD34+细胞上的阳性表达仅1/3例，平均阳性细胞数为1.25 ％。2B8a抗原在B系细胞系Raji、SMS-SB、Nalm-6和Nall-1上的平均阳性细胞数分别为98.78 ％、98.61 ％、94.93 ％和5.68 ％；在T系细胞系Molt-3上的平均阳性细胞数为31.40 ％，而在Molt-4、JM和CCRF-CEM 细胞上不表达；在髓系细胞系U937、Meg-01、HL-60、K562、KG1a和HEL92.1.7上的平均阳性细胞数分别为67.78 ％、33.40 ％、29.70 ％、28.19 ％、16.23 ％和8.02 ％；在神经母细胞瘤细胞系SK-N-SH、KCNR、BE、LAN-1和SK-N-AS细胞以及结肠癌细胞系HR8348细胞上均不表达，而在羊膜细胞系FL细胞上呈一定的阳性表达，平均阳性细胞数为45.03％。

The aim of this study was to investigate the expression levels of genes psma6 and slc25a4 in bone marrow of patients with acute monocytic leukemia and their correlation with clinical features and prognosis.

本研究探讨psma6、slc25a4基因在急性单核细胞白血病(AML-M5)患者中的表达水平，并分析其与临床特征和预后的关系。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。