查询词典 malignancies

Objective:To further define the ultrastructural features of the lymphocytic malignancies.

目的：进一步认识淋巴源性肿瘤的超微结构形态改变的特征。

Renal-cell carcinoma, clear-cell sarcoma, mesoblastic nephroma, rhabdoid tumour, and renal medullary carcinoma form a heterogeneous group of childhood renal malignancies known as non-Wilms' tumours.

肾细胞癌、透明细胞肉瘤、先天性中胚叶肾瘤、横纹肌样瘤以及肾髓质癌均为来自于名为非 Wilm 肿瘤的一种儿童肾脏恶性肿瘤。

Recombinant human Mullerian inhibiting substance suppresses the growth of MISIIR-positive ovarian cancer cells by inducing apoptosis and cell cycle arrest. We predict that rhMIS might be a new target to treat human ovarian malignancies.

重组人苗勒抑制物可以抑制MISIIR蛋白表达的卵巢癌细胞增殖、诱导其凋亡、阻滞细胞周期，这有望成为治疗卵巢癌的一个新靶点。

Methods The expression and change of TF and TFPI were detected in the peripheral venous blood samples from 20 normal controls, and 78 patients with haematological malignancies—34 patients with acute leukemia, 12 with chronic myeloblastic leukemia, 12 with non-Hodgkin lymphoma, 7 with multiple myeloma, 6 with myeloproliferative disorders, and 7 with myelodysplastic syndrome, by enzyme linked immunosorbent assay. After that, the correlation of TF and TFPI were analyzed.

选择正常对照组20例，恶性血液病组78例，其中急性白血病34例，慢性粒细胞白血病12例，非霍奇金氏淋巴瘤12例，多发性骨髓瘤7例，骨髓增殖性疾病6例；骨髓增生异常综合征7例。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Allogeneic stem cell transplantation is the main treatment of choice for many hematological malignancies, as well as some nonmalignant hematological disorders, but disease relapse is still the most significant obstacle to allo-HSCT.

异基因造血干细胞移植是目前许多恶性血液病和一些非恶性疾病的主要治疗手段，但疾病的复发仍是影响allo-HSCT效果的主要原因。

Petechiae, ecchymoses,"pinch purpura," and caput medusae are some of the vascular lesions associated with malignancies.

瘀点、瘀斑、&挤压性紫癜&和脐周静脉曲张是与某些恶性肿瘤有关的血管性损害。

Petechiae, ecchymoses,"pinch purpura," and caput medusae are some of the vascular lesions associated with malignancies.

瘀点、瘀斑、&拧捏性紫癜&和脐周静脉曲张是与某些恶性肿瘤有关的血管性损害。

The studies of photodynamic therapy for malignancies have been developing thrively in recent years.

光动力学治疗法作为一种新的肿瘤治疗方法，近年来发展十分迅速。

Sarcosine and other metabolites are easily detectable molecules, and the door is now wide open for the development of new diagnostic and prognostic tests in prostate cancer and other malignancies, which we urgently need.

给予外源性肌氨酸或敲除导致肌氨酸降解的肌氨酸脱氢酶后，可以诱导良性前列腺上皮细胞表型发生恶性转变。雄激素受体和ERG 融合基因产物共同调节肌氨酸信号通路元件。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。