查询词典 malignancies

Background: Prostate adenocarcinoma is one of the major malignancies of the genitourinary system.

背景和目的：前列腺腺癌是泌尿生殖系统的主要恶性肿瘤之一。

It also is related to bone marrow structural damage resulting from tumor invasion,large proliferation of granulation or fibrous tissue,which often affect hemopoiesis.Leukemoid reaction occurred in the majority of malignancies is myeloid leukemia response,among which some are.neutropenia,and even agranulocytosis and increasion or decreasion of platelets.These are all have close relationship with marrow invasion of malignant tumor,immune reaction of the body and chemotherapy as well as radiotherapy.

亦与骨髓被恶性肿瘤细胞浸润、肉芽和纤维组织大量增生，使骨髓结构破坏，影响红系造血有关；绝大多数恶性肿瘤并发的类白血病反应是粒细胞性的，部分患者白细胞减少，甚至粒细胞缺乏，以及血小板增高或减少，均与恶性肿瘤细胞骨髓浸润、机体的免疫反应、放化疗有关。

Gastric cancer is one of the most common malignancies in China, and is at the first place in alimentary tract malignancies.

胃癌是常见的恶性肿瘤之一，目前，我国发病率仍高居恶性肿瘤第一位。

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

More than 95% of these malignancies are cholangiocarcinomas frequently found in the extrahepatic biliary tree.

这些恶性肿瘤的95%以上是肝外胆道系统的胆管癌。

The Mayo Clinic team led by Lisa Boardman, M.D., a specialist in gastrointestinal malignancies, investigated the structures inside of cells known as telomeres, which are the caps on the ends of chromosomes that keep chromosomes from unraveling.

Mayo临床研究小组由恶性消化系统疾病专家Lisa Boardman博士领导，该小组对细胞内部的端粒酶进行研究，端粒酶是染色体两端的帽状结构，它可以保持染色体结构的完整性。

Predefined health events included malignancies, coronary artery disease, and thrombosis.

预先界定健康事件包括恶性肿瘤，冠心病和血栓形成。

Objective Chronic myeloid leukemia, with of chromosome, is one of primary clonal malignancies of hemapoietic stem cell. Philadelphia chromosome is the hallmark of malignancies clone in CML.

研究背景与目的：慢性髓系白血病是一种原发于多能造血干细胞的恶性克隆性疾病，第9号与第22号染色体相互易位形成Ph染色体是其肿瘤恶性克隆性标志。

To investigate the clonal rearrangements of immunoglobulin heavy chain gene and T-cell receptor γ gene in peripheral blood cells of patients with hemapoietic malignancies and their significance, the clonal rearrangements of IgH and TCRγ genes were detected by polymerase chain reaction in peripheral blood cells of patients with hemapoietic malignancies, including 32 cases of non-Hodgkin lymphoma, 18 cases of acute myeloid leukemia, 24 cases of multiple myeloma, 8 cases of acute lymphoblastic leukemia and 6 cases of chronic lymphoblastic leukemia.

检测各种血液系统肿瘤患者外周血细胞免疫球蛋白重链基因和T细胞受体γ基因克隆性重排并探讨其意义。通过多聚酶链式反应方法检测32例非霍奇金淋巴瘤、18例急性髓性白血病、24例多发性骨髓瘤、8例急性淋巴细胞白血病及6例慢性淋巴细胞白血病患者外周血细胞IgH及TCRγ克隆性基因重排。

However, this study groups together both haematological malignancies, most notably lymphoma, and non-haematological malignancies in the analysis.

在所纳入研究中的接受抗TNF抗体治疗的患者，在6～12月治疗期内发生1例恶性肿瘤临床危害需要人数为 154 (95% CI， 91-500)。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。