查询词典 lymphoblastic

Methods P-gp expression in 151 acute myeloblastic leukemia and 47 acute lymphoblastic leukemia was determined by monoclonal antibody UIC2 and flow cytometry. Results The rate of complete remission differred between P-gp+ and P-gp?

采用流式细胞术及单克隆抗体UIC2检测了151例成人急性髓细胞白血病、47例成人急性淋巴细胞白血病患者的白血病细胞P-gp表达。

Specific siRNA was used to target LMO2 in Molt-4 cells. Results Higher expression of LMO2 was detected in some of patients with acute myeloblastic leukemia or acute lymphoblastic leukemia. However, enforced expression of LMO2 in K562 cells decreased cellular clonogenecity, suggesting the activation of the gene may not be important in the pathogenesis of myeloid leukemia.

结果 LMO2基因在很多急性髓系和淋巴系白血病患者的表达水平高于慢性白血病患者及正常骨髓细胞，但LMO2转染的K562细胞克隆形成率下降，提示该基因在髓系白血病细胞的表达异常是一种伴随结果而不具有致癌作用。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Ph^1 was observed in all 11 cases of chronic myelocytic leukemia and 3 of the 7 cases of acute lymphoblastic leukemia; chimera was found in 1 of the 7 ALL cases and 4 cases demonstrated-22,+Mar, del(11)(q^23) and normal karyotyp or multiploid.

其中11例慢性粒细胞白血病，均可见费城染色体（即Ph^1）。7例急性淋巴细胞性白血病中有3例出现Ph1，其中1例为嵌合体，其余4例急性淋巴细胞白血病中分别出现－22，+MarD？

Methods The expression of CD87 was detected with flow cytometry in 54 AML patients and 20 acute lymphoblastic leukemia patients. The expressionsa of CD87 on U 937, HL-60 and K562 cells were also studied with FCM and reverse transcription-polymerase chain reaction during differentiation induced by phorbol myristate acetate in vitro.

应用流式细胞术检测了54例急性髓性白血病及20例急性淋巴细胞白血病患儿CD87的表达，还用FCM及逆转录-聚合酶链反应法检测了U937、HL-60、K562细胞在氟波酯作用下诱导分化过程中CD87表达的改变。

FINDINGS: Somatically acquired JAK2 mutations were identified in 16 (18%) patients with Down's syndrome-associated acute lymphoblastic leukaemia.

结果：唐氏综合征相关的急性淋巴母细胞白血病患者中有16例（18％）鉴定出了获得性体细胞JAK2突变。

However, on 4th March 2009, her life took a fatal turn. She was diagnosed with Acute Lymphoblastic Leukemia, a life-threatening disease that will post a staggering SGD 400,000 medical bill to her middle-income family (Xiaoou's mother is unemployed. Her father is a normal worker with average income of SGD 400 per month).

就在这梦想愈发清晰的边缘，一切都在一纸急性淋巴性白血病确诊通知书前面，瞬间崩塌了。40万新币的医药费对于她工薪阶层的家庭来说，是个天文数字（她妈妈下岗多年，爸爸是月收入约2000元人民币的普通职工）。

Mercaptopurine should remain the thiopurine of choice for continuing therapy of childhood lymphoblastic leukaemia.

在儿童淋巴细胞白血病的持续治疗阶段，若要选择巯基嘌呤类药物，仍应选 6-巯基嘌呤。

Mercaptopurine has been a standard component of long-term continuing treatment for childhood lymphoblastic leukaemia, whereas 6-thioguanine has been mainly used for intensification courses.

背景6-巯基嘌呤是治疗儿童淋巴细胞白血病的一种标准的长期维持用药，而 6-硫鸟嘌呤则主要用于强化治疗。

ALA-PDT alleviated GVHD following allo-BMT and preserved GVL in ALL mice One-way mixed lymphocytes predisposed with ALA-PDT and marrow cells from the donors were infused into ALL mice. The body weight increase, haematogenesis recovery and survival time were better then all the other groups.

ALA-PDT减轻急性淋巴细胞白血病(acute lymphoblastic leukemia，ALL)小鼠同种异基因骨髓移植后GVHD反应，并且保留了GVL效应将经过ALA-PDT处理过的单向混合淋巴细胞联合供鼠的骨髓细胞输注给ALL小鼠体内，ALL受鼠的体重增长情况、造血功能恢复情况及无病生存时间等指标明显好于对照组。

I will endeavour to find you some assistance.

我尽力帮你找人帮忙。

At first I only know bruck is the idol of American younglings, afterwards I returned back to Taiwan ,even in Beijing last year ,I saw her poster everywhere, I was so surprised at her charm.

起初我只晓得布鲁克雷德丝是美国少男少女崇拜的偶像，后来回台湾，甚至去年在北京，居然也四处看见她的海报，才惊讶她的魅力之大。