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The pleural superficial, subpleural and parenchymal vacular networks were denser, and the range of the microvessels in diameter were larger, and the proceeding distance of the subpleural arteriole and its branches were longer in the adult yak lung than those in the adult cattle lung. However, the anastomosing between the pleural superficial and the subpleural vascular networks were more often found in the adult cattle lung than that in the adult yak.

成年牦牛肺胸膜面浅层的微血管网、胸膜下微血管网以及肺实质内的微血管网比成年黄牛致密;成年牦牛肺微血管的管径范围比黄牛的大;成年牦牛肺胸膜下微动脉及其分支的走行路径比成年黄牛的长;而成年黄牛肺胸膜面浅层的微血管与胸膜下微血管之间的吻合比成年牦牛更为常见。

Methods Both in vitro and in vivo models of ventilator-induced lung injury were used. Alveolar epithelial cells were stretched in vitro to mimic the lung injury in VILI. Rats were ventilated at large tidal volume to produce ventilator-induced lung injury in vivo. A total of 23 inflammatory cytokines were screened with micro gene array in stretched alveolar epithelial cells.

方法通过呼吸机诱导肺损伤的体内及体外模型,将分离的肺泡上皮细胞于体外拉长,利用基因微阵列技术分析并筛选出上调的炎性细胞因子,之后给予大鼠呼吸机机械通气,留取血清标本,测量这些细胞因子在血清中是否上调。

Compare the lung injury extent and the important physiological parameters to determine the optimal condition for rabbit ventilator induced lung injury, Choosing another 24 new Zealand rabbit, randomly divided into 4 groups:(1)conventional ventilation+PEEP group;(2)ventilator induced lung injury group: employ the experimental condition determined by the first part experiment;(3)VILI+HO-1 inducer hemin group:pre-treated with HO-1 inducer, the ventilation method is the same with VILI group;(4)VILI+HO-1 inhibitor Zn-PP group(Zn-PP group):pre-treated with HO-1 inhibitor, the ventilation condition is the same with VILI group.

第二部分24只家兔随机分为4组:(1)常规潮气量+PEEP组;(2)呼吸机所致肺损伤组:使用实验第一部分确定的最适条件;(3)呼吸机所致肺损伤+HO-1诱导剂干预组:预先给予氯铁血红素,通气条件同VILI组;(4)呼吸机所致肺损伤+HO-1阻断剂干预组:预先给予锌原卟啉,通气条件同VILI组。

Traditional machinery aerates send lung ventilator dependency pneumonic , lung ventilator (the happening of the complication such as ALI), remove machine difficulty to lung ventilator is depended on and be being sent. In June 2005 ~2007 year in December, we are used without achieve machinery to aerate auxiliary cure spends organic phosphor again toxic choline can high resemble and ARF 30 exemple, effect satisfaction.

传统机械通气致呼吸机相关性肺炎、呼吸机相关肺损伤等并发症的发生,并对呼吸机依靠而致撤机困难。2005年6月~2007年12月,我们采用无创机械通气辅助治疗重度有机磷中毒胆碱能危象并ARF 30例,效果满足。

Lung cancer is one of the most malignant tumors which is hazarding to thepeople's health,and the incidence and motality of lung cancer is increasing in ourcountry.It is most important to research the mechanism of oncongenesis anddevelopment of lung cancer.

肺癌为我国发病率和死亡率增长最快,对人类健康和生命威胁最大的恶性肿瘤之一,对其发生和发展机制的研究是十分重要的。

The aim of this study is to investigate the relationship between PPAR-γ expression and clinicopathological characteristics of lung cancer, and to discuss the effect of PPAR-γ activators on lung cancer growth and the mechanisms of apoptosis induction for lung cancer.

本研究的目的是分析PPAR-γ的表达与肺癌临床病理特征之间的关系,并探讨PPAR-γ的配体对肺癌细胞生长的影响及其诱导凋亡的机制。

To investigate the relationship between peroxisome proliferators-activated receptorgamma and clinical pathology of lung cancer, and to study the inhibitory effect of PPAR-γ activators on lung cancer growth and the mechanism of inducing apoptosis of lung cancer.

目的研究过氧化物酶体增生物激活受体的表达与肺癌临床病理之间的关系,并探讨PPAR-γ的激动剂对肺癌细胞生长的影响以及诱导其凋亡的机制。

Compared with the control, the lungs of 3-day-hyperxia-exposure group developed into edema, hemorrhage and inflammatory infiltration and this condition aggravated at the 7th day. The pulmonary septum was significantly widened at the 14th day, the interstitial fibrocytes as well as alveolar epithelial cells proliferated obviously, and the tendency of lung fibrosis was also presented. The results mentioned above showed that the modle of hyperoxia lung injury was successfully established, and the acute inflamationm was its early symptom while the fibrosis was its late manifistation. There was no positive cytes of IFN-γ in the lung of nomal rats, The positive cytes of the groups under hyperxia-exposure for 3, 7, 14 day, which climbed to the climax at the 7th day and began to decline from the 14th day, were found in alveolus epithlia,pulmonary interstitial, bronchoepithlia and macrophage.

高氧14天(5.46±0.30)虽有所下降,但同空气组比,差异仍然具有显著性(P.05);BALF中蛋白含量高氧3天(0.45±0.10)、7天(0.66±0.08)、14天(0.79±0.14)显著高于空气组(0.18±0.08,P值均。05);肺通透系数高氧3天(6.61±2.05)、7天(10.88±1.54)、14天(12.75±2.20)均明显高于空气组(2.99±1.27,P值均。05);同时病理组织学改变也表明与空气组比较,高氧3天时肺组织水肿、出血、炎性细胞浸润,7天时进一步加重,14天时肺间隔明显增宽,间质纤维细胞和肺泡上皮细胞明显增生,出现肺纤维化倾向;以上结果均表明我们成功地建立了高氧肺损伤动物模型,且急性炎症反应是其早期表现,纤维化改变是其晚期表现。

As well as enhancing the specification of distal lung epithelium, this protocol was found to yield cells with a phenotype most closely resembling that of lung-committed progenitor cells present in the foregut endoderm and the early lung buds during embryonic deelopment.

除了提高末梢肺上皮的数量,这一个方法被发现产生了在胚胎发育期间最接近表达在前肠内胚层和早期肺芽表型的细胞。

When existing a relatively large juxta-pleural nodule in lung CT image,because of the lacunas in the segmented lung,the attached nodules may not be distinguishable from the lung.

在计算机辅助CT图像肺部肿瘤诊断系统中,当肺区内部存在较大粘连肿瘤时,将导致分割出来的肺区存在较大的缺陷,因而在肺区内部就无法识别粘连肿瘤。

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