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Anticoagulant therapy not only reduce the characteristic hypercoagulability of cancer, but also inhibits growth and metastasis of cancer, and alters the fundamental biology of cancer. In this paper thrombin and its receptor, relationship of t...

本文就凝血酶及其受体、凝血酶及其受体与肿瘤生长、转移及血管新生的关系、凝血酶影响肿瘤血管新生的可能机制及抗血管新生和抗凝治疗的应用前景进行了综述。

Objective To study the expression of epithelial-cadherin in breast cancer cells and the microvessel density in breast cancer mesenchyma, and to analyze the correlation between two factors and metastasis in breast cancer.

目的：研究乳腺癌细胞上表皮细胞黏附分子的表达和癌间质的微血管密度，并分析E-cd和MVD与乳腺癌转移的关系。

METHODS: CD44v6 protein was detected by SP immunohistochemical method in the tissues of rectal cancer, mesorectum (2 cm distal from the tumor), and distal mesorectal margin (5 cm distal from the tumor) from 47 rectal cancer patients received total mesorectal excision. RESULTS: CD44v6 was highly expressed in the tissues of rectal cancer.

行全直肠系膜切除术的直肠癌患者47例于直肠癌组织、直肠系膜（距肿瘤下缘2 cm）、直肠系膜远端切缘（距肿瘤下缘5 cm）取病理标本，采用免疫组化SP法对标本进行CD44v6检测。

Burstein, MD, PhD, from the Dana-Farber Cancer Institute and Harvard Cancer Center in Boston, Massachusetts, reported phase 2 results of a trial that randomized 62 women with stage IV breast cancer to metronomic chemotherapy (oral cyclophosphamide 50 mg/d once daily and oral methotrexate 2.5 mg twice daily on days 1 and 2 each week) with or without intravenous bevacizumab (10 mg/kg every 14 days).

Burstein医师报告一项第2期临床试验结果，这项临床试验收纳了62位第4期乳癌接受节律性化学治疗（在每周的第一、二天口服cyclophosphamide每天50毫克，以及口服methotrexate 2.5毫克每天两次），加上或是不加上bevacizumab（10毫克公斤，共14天）；「节律性」疗程被定义为使用低剂量、重复投予的化学疗法。

The two livin isoforms are expressed in gastric cancer tissues. As molecula rmarker of gastric cancer, livin may be a new target of therapy for gastric cancer.

Livin的两异构体在胃癌组织中的表达使其可能成为胃癌的分子标记物或胃癌治疗的新靶点。

We performed a hospital-based, case–control study of 100 patients with newly diagnosed oropharyngeal cancer and 200 control patients without cancer to ealuateassociations between HP infection and oropharyngeal cancer.

我们进行一项以医院为基础的病例对照研究，研究对象为100名新近诊断的口咽癌患者和200名为未患癌症的对照患者，研究评价人乳头状瘤病毒感染与口咽癌的相关性。

Survivin might be overexpress in early gastric cancer, and it could correlate with the prognostic with early gastric cancer, which can be an detective indicator for patients with early gastric cancer.

生存素在早期胃癌组织中有较高的表达率，其表达与胃癌的预后呈正相关，可作为早期胃癌的检测指标。

objective:to analyze the difference between mammary duct ectasiaand plasma cell mammitis.methods:the data of 24 cases of mde and 28 cases of pcm,including clinical manifestations,distinguished diagnoses,surgical therapy,pathological results,were analyzed.results:the clinical manifestations of mde are nipple discharge and breast mass,which should be distinguished with breast mass and early stage of breast cancer.the treatment is local resection.major pathological changes are duct ectasia and obvious periductal inflammatory changes.the clinical manifestations of pcm are breast mass and inflammatory changes,which should to be distinguished with advanced breast cancer and inflammatory breast cancer.the surgical treatment is extensive resection.the major pathological changes are inflammatory reaction and multiple abscesses in breast tissue.conclusion:mde and pcm are significant different,and they are different progressing stage of disease,thus the two diagnoses are independent.

目的：分析乳腺导管扩张症和浆细胞性乳腺炎临床上的差异。提出各自独立诊断的论据。方法：结合24例乳腺导管扩张症和28例浆细胞性乳腺炎对两病的临床症状、鉴别诊断、手术治疗、病理结果进行比较分析。结果：乳腺导管扩张症临床表现为乳头溢液和乳腺肿物，主要与乳腺肿物和早期乳腺癌鉴别诊断，手术以局部切除多见，病理表现为导管扩张及导管周围明显炎性改变。浆细胞性乳腺炎临床表现为乳腺肿物和炎性改变，主要与晚期乳腺癌和炎性乳腺癌鉴别诊断，手术切除的范围较大，病理变化以乳腺组织的炎性反应和多发性脓肿为主。结论：乳腺导管扩张症和浆细胞性乳腺炎有明显的差异，应作为这两种疾病独立诊断。

We study the express of heparinase,matrix metalloproteinase MMP-2,MMP-14 and cadherin in the gastric cancer tissue and perigastric normal mucosal tissue,and make a statistics analysis between heparinase, matrix metalloproteinase MMP-2,MMP-14,E-cadherin and gastric cancer biological behavior.We hope to knom the possibility that heparinase,matrix metalloproteinase MMP-2,MMP-14,E-cadherin are regared as clinical screen index of the gastric cancer recrudescence or metastasis.

本文就肝素酶、基质金属蛋白酶MMP-2、MMP-14、钙粘蛋白在胃癌组织及胃周正常粘膜的表达进行了研究，并就肝素酶、基质金属蛋白酶MMP-2、MMP-14、钙粘蛋白与胃癌的生物学行为进行了统计学分析，以期了解肝素酶、基质金属蛋白酶MMP-2、MMP-14、钙粘蛋白作为胃癌复发或转移的临床筛选指标的可能性。

At early stage of cancer cell formation, provoked autophagy help to eliminate damaged cell organelle、and degrade the noxious substance in endochylema(eg: peroxidate)as well, pretect normal cells from cancerization.Autophagy level modulation might be cooperation or rivalry with chemotherapy to cancer cells compares to single use of chemotherapy drugs, apoptosis rate of cancer cells fluctuates with autophagy level.

癌细胞形成早期刺激自噬能够清除受损细胞器，分解细胞内过多的有害物质，阻止正常细胞向癌细胞转化，调控自噬的表达和化疗药物联合对肿瘤细胞的生长有协同或拮抗作用，表现为与单纯用化疗药物相比，调控自噬表达后肿瘤细胞的凋亡率发生了变化。

Methods Clinical data of 3 cases of bile duct injury during laparoscopic cholecystectomy were analyzed retrospectively.

回顾总结3例LC术中胆管损伤的临床资料，分析3例胆管损伤的原因及对策。

These techniques are applied to the gobang.

本文将这些技术用于五子棋中。