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Our previous studies have shown that ubiquitous overexpression of HmgD caused hemocytes proliferation and the formation of melanotic tumors in the Drosophila larvae. To clarify the mechanism of melanotic tumors appearance,we also generated RT-PCR analysis to test the transcriptional changes of PPAE and Spn27A,which encode the key factors in the phenoloxidasecascade pathway from larvae samples of mid-third instar,late-third instar and prior to pupation relative to wild type flies.Our result showed that in the HmgD overexpression mid-third instar larvae,the expression level.of Spn27A was lower than wild type,otherwise the expression level of PPAE was higher than wild type.It suggests that overexpression of HmgD affects the PO cascade pathway.

本研究组前期工作发现,过量表达HmgD引起果蝇幼虫体内血细胞增生,并出现黑色素瘤,为探讨HmgD过量表达导致了血细胞增生即形成黑色素瘤的分子机制,本研究分别提取三龄中期、后期和相对于野生型化蛹前时刻的幼虫的RNA,首先检测了编码酚氧化酶级联反应途径中的两个关键基因PPAE,Spn27A在突变体中的转录发生变化,结果发现,Spn27A在三龄中期的表达量低于野生型,而PPAE的表达高于野生型,表明过量表达HmgD影响了酚氧化酶级联反应途径,低水平的Spn27A不足以抑制PPAE的活性,活化的PPAE催化了PPO的活性,使其转变成有活性的PO,从而促进黑色素的生成,使果蝇体内产生黑色素瘤。

Methods 120 SD rats were divided randomly into blank group, model group, Baoliezhi control group and Qianliening granule groups with different doses. The models were established with hypodermic injection of testosterone propionate at 4 mg/kg after orchiectomy, at the same time, these rats were gastric perfused with different drugs respectively for 30 days. The body weight, prostate weight, prostate index, morphological changes, the level of T and E2 were measured. Results The body weight in model group was significantly lower than that in control group (P.05), the prostate weight and index were obviously higher than that in control group (P.01). The prostate weight and index were decreased significantly in Qianliening granule groups with meddle and high doses (P.01), the level of testosterone was increased significantly and E2 was decreased obviously in Qianliening granule group with high doses.

将雄性SD大鼠60只,随机分成空白组、模型组、保列治治疗对照组、前列宁颗粒低、中、高剂量组,采用丙酸睾丸酮皮下注射引起大鼠前列腺增生模型,连续给药30d后,观察6组动物体重前列腺湿重前列腺指数前列腺组织形态血清睾酮雌二醇(E2)水平的变化结果模型组大鼠体重较正常组明显减轻(P.05),而前列腺重量和前列腺指数明显升高(P.01);前列宁颗粒中、高剂量组的前列腺重量和前列腺指数明显下降(P.01);前列宁颗粒高剂量组可明显升高大鼠血清T水平,降低E2水平,使T/E2比例升高。

The results indicated phthalid acid, benzoic acid and cinnamic acid all inhibited the germination of different processed tomato varieties, which caused lower germination rates and shorter radicle compared with those of ck. The difference reached significant level or extremely significant level.

结果表明:邻苯二甲酸、苯甲酸和肉桂酸均抑制了加工番茄不同品种种子的萌发,表现在萌发率、胚根长较对照均有所降低,差异达到显著或极显著,而且随有机酸浓度的增加,这种抑制程度也逐渐增强。

The left ventricle ponderal index (92.35±19. 03) and LVEF [ (50. 14±7. 23)%] of GH low level group were lower than those of normal level group (P. 05 all). Conclusion; There is significant influence of GH on aged cardiovascular system. Growth hormone ; Cardiovascular system ; Aged

本研究对老年人血液生长激素水平和心室壁厚度以及心脏射血分数的关系进行分析,探讨生长激素水平对心功能的影响。1资料与方法1.1一般资料研究对象均为1999~2001年我院住院的患者,男72

Thyroid gland is located in cervical in front, Adam's apple lower part, tracheal two side, it is the endocrine organ with main human body, assume human body to absorb with memory iodine, synthesize and secrete the function of thyroid element, include estrogen and progestational hormone inside female hormone, participated in the happening of thyroid cancer, development probably, level of the estrogen inside body is higher, make thyroid cancer more possibly happen, 20-40 year old the female is in life exuberant period, level of the hormone inside body is lifetime in most

甲状腺位于颈部前面、喉结下方、气管两侧,是人体重要的内分泌器官,承担人体摄取和存储碘,合成和分泌甲状腺素的功能,包括雌激素和孕激素在内的女性激素,很可能参和了甲状腺癌的发生、发展,体内雌激素水平越高,越可能促使甲状腺癌发生,20-40岁女性处于生命旺盛期,体内激素水平是一生中最

Objective To study the mechanism in which the personality, copying style influenced survival time by changing immunity function in the patients with gastric cancer Methods The Minnesota Multiphase Personality Inventory, coping style questionnaires and immunity function were measured in patients with gastric cancer on late stage, gastric cancer patients with longer survival time, and normal control Results Psychopathic deviate, social introversion subscale scores of MMPI in groupⅡ were significantly lower than that in the other two groups ( P 05) Statistical difference were found between groupⅠand groupⅡ in problem saving factor and help seeking factor of CSQ ( P 05) Natural killer cell level in groupⅡ was significantly higher than in groupⅠ( P 05) There was negative correlation between the NKC and depression, psychopathic deviate, paranoia, psychasthenia, schizophrenia subscale scores of MMPI, there was positive correlation between NKC and SP, coping type in patients with gastric cancer Conclusion The gastric cancer patients with longer survival time are more extroversive and have more mature coping styles Their NKC level is relatively higher The results may be advantageous to improve the prognosis of gastric cancer

作者中文名:王健;邹义壮;唐丽丽;李杰;张东;金山;刘娟摘要:目的研究胃癌患者的生存期与个性特征、应付方式等心理因素,以及免疫功能的关系。方法对胃癌晚期患者、胃癌较长生存期患者及正常健康人分别进行明尼苏达多相个性测验、应对方式问卷、免疫功能测试,并做相关分析。结果(1)MMPI:胃癌Ⅱ组人格障碍评分(42.0±10.5)及社会内向评分(42.2±11.6),低于其他两组[胃癌Ⅰ组为(49.3±11.2)分和(48.3±9.4)分,对照组为(48.6±10.9)分和(39.9±11.5)分;P均<0.05];(2)CSQ:解决问题和求助因子分,胃癌Ⅰ组[分别为(0.68±0.27)分和(0.42±0.18)分]均低于胃癌Ⅱ组[分别为(0.82±0.18)分和(0.65±0.21)分;P<0.05和P<0.01],胃癌Ⅱ组更多采取成熟的应对方式;(3)自然杀伤细胞:胃癌Ⅱ组水平(21.4±9.2)高于胃癌Ⅰ组[(14.2±8.8);P<0.05];而NK细胞水平与MMPI的抑郁(r=-0.35)、人格障碍(r=-0.39)、偏执(r=-0.29)、精神衰弱(r=-0.30)及精神分裂(r=-0.30)等量表呈负相关,与CSQ的解决问题因子(r=0.35)及应付方式类型(r=0.34)呈正相关。结论与胃癌Ⅰ组比较,胃癌Ⅱ组更为外向,负性情绪较少,更多采取成熟的应对方式,其NK细胞水平较高,对胃癌的预后产生了积极的影响。

The resol phenol-formaldehyde adhesive could be prepared from liquefied wood (wood: phenol=1:2) in phenol at r(subscript F/P) 1.8, r(subscript NaOH/P) 0.7 and resinification temperature 80℃. The physical properties of the poplar three-layer plywood bonded with LWR were similar to those with normal PF resins and also satisfied the demands of I level. Free formaldehyde content of plywood (0.1 mg/L) was lower than the E0 level set by GB/T 9846-2004 Plywood.

结果表明,采用料液比为1:2的液化物,F1.8,r0.7,树脂化温度80℃条件下合成的杉木液化物树脂压制的杨木三层胶合板满足I类胶合板强度要求,各项物理力学性能与常规PF树脂压制的板材相当,板材的甲醛释放量为0.1mg/L,远低于GB/T 9846-2004《胶合板》中的E0级要求。

Results The level of antibodies against monocytes (34.94%) were higher than that of the antibodies against lymphocytes (26.67%) in pretransplant patients. The level of antibodies in first time transplant patients (32.5%) was lower than that of antibodies in retransplant patients (59.7%). The patients with intensity of antibodies against monocytes PRA more than ≥50% only accounted for 1.87%, 10%< MPRA <50% for 17.62% and MPRA <10% 15.44%,respectively.

结果 肾移植术前患者的抗单核细胞抗体水平较抗淋巴细胞抗体水平高,其百分比分别为34.94%和26.67%;而从患者初次和再次肾移植前的比较中可见,初次比再次产生的抗单核细胞抗体水平要低,其百分比分别为32.05%和59.7%;对于抗单核细胞抗体群体反应性抗体的强度,MPRA≥50%的只占1.87%,而50%<MPRA>10%以及MPRA<10%的分别占17.62%和15.44%。

Results the serum level of mmp-2 in study group was significantly higher than that of controls (p<0.01). the more critical by classification of child-pugh, the lower serumal mmp-2 level (a grade vs b grade, b grade vs c grade,c grade vs a grade;p<0.01, p<0.01, and p<0.01, respectively).

结果 肝硬化组mmp-2显著高于对照组(p<0.01、);但是肝硬化患者血清中mmp-2浓度随child-pugh分级增高显著下降,a、b、c级之间差异均有统计学意义(p均<0.01),mmp-2水平a>b>c。

As they form the level of ionisation gradually builds up, affecting first the lower frequencies, and later higher frequencies as the level of ionisation increases.

当他们形成电离的水平逐渐加强,首先影响更低的频率,和最新更高的频率作为电离增量的水平。

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Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气,收缩臀部肌肉;拱起身体,尽量抬起头来,右腿伸直朝向天花板(膝微屈,以避免肌肉紧张)。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

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