查询词典 liposomes

Results The optimum preparation formulation:drug/PC:1∶30,liposomes were pH 7.4 outside and incubated at 30℃.The encapsulation rate of Vinorelbine Bitartrate in liposomes was above 85%.

结果 制备重酒石酸长春瑞滨脂质体的最佳条件是药物与磷脂的质量比为1∶30，胆固醇与磷脂质量比为1∶4，脂质体外水相pH值最终调至7.4，孵育温度为30℃，此时的包封率可以达到85%以上。

To understand the behavior of cantharidin release, the conventional liposomes and modifier liposomes, revealed that there were no significant difference in size and the rate of drug release at 25℃ and 4℃.

关於斑蝥素渗漏实验，无论是在25℃及4℃下，传统型与表面修饰型(添加1wt﹪几丁聚醣)微脂粒的粒径与渗漏速率，都无明显差别。

Physical stability of liposomes plays the critical roles in various stages of the applications and development of liposomes. In this study, we applied low molecular weight chitosan to modify the liposomes surface, and investigated the physical stability of liposomes, Moreover, we encapsulated cantharidin to study the effects of chitosan which cause drug leakage.

微脂粒稳定性的研究在其应用发展上占有举足轻重的影响，因此本研究利用低分子量水溶性几丁聚醣来修饰微脂粒表面，观测几丁聚醣对微脂粒物理稳定性的影响，同时也一并探讨包覆抗癌药物斑蝥素，几丁聚醣对微脂粒包覆斑蝥素的渗漏情形。

It was also found that at experimental concentrations there was no regularity for the change of activity of copper salicylate encapsulated in negatively charged liposomes, and copper salicylate encapsulated in liposomes with more negative charges could promote the dismutation of superoxide anion free radicals, however, so could copper salicylate encapsulated in liposomes with fewer negative charges only in lower concentrations.

并发现在实验浓度范围内，负电性脂质体包裹的水杨酸铜，活性变化无规则，且荷负电量多的脂质体包裹的水杨酸铜促进超氧自由基的歧化，而荷负电量少的脂质体仅在低浓度区对超氧的歧化表现为促进作用。

Both the increase of lipid peroxidation reaction rate and the shortening of the latent period were dependent on the pre-existed lipid peroxides in liposomes. Al3+ accelerated the oxidation of Fe2+ in liposomal system only when liposomes contain pre-exist peroxides. The addition of Al3+ to the liposomal suspension resulted in a marked increase of turbidity of the suspension and decrease of fluidity of the liposomes.

这可能是因为在脂质体存在的条件下，Al3＋加速了Fe2＋的氧化，且加速作用与脂质体中原先存在的过氧化物的含量有关；另一方面，Al3＋可以引起脂质体的聚集，表现为浊度的增加；测量脂质体上标记的脂肪酸自旋标记物5－ Doxyl stearic acid 的ESR 波谱发现： Al3＋降低了脂质体的膜脂的流动性。

After tail iv injection, the blood exposure time of stealth liposomes and the area under blood drug concentration-time curve were pronouncedly increased, compared with the regular liposomes group and the free doxorubicin group,respectively.

以化学梯度法包封脂质体，用两亲性聚乙二醇-二硬脂酰磷脂酰乙醇胺对脂质体膜进行修饰以制备隐形脂质体；用HPLC-UV法测定给药后小鼠体内组织中的药物浓度。

Mouse MR imaging assessed MFLs efficiency as contrast agents in vivo: MR angiography performed 24 h after intravenous injection of the contrast agent provided the first direct evidence of the stealthiness of PEG-ylated magnetic-fluid-loaded liposomes

描绘的老鼠先生估定了 MFLs 效率当做差别代理人在活泼地： angiography 先生在差别代理人的静脉内注入之后运行了 24 h 提供了钉-ylated 磁性的 stealthiness 的第一个直接证据-液体-装载 liposomes

Objective: Novel liposomes composed of hydrogenated soybean phosphatidylcholine and soybean phosphatidylcholine was prepared to encapsulate total alkaloids from seed of Strychnos nux-vomica. The pharmaceutical properties of the novel liposomes were compared with corresponding HSPC or SPC liposomes.

中文摘要：目的：制备了以氢化大豆磷脂和普通大豆磷脂为膜材的马钱子总生物碱复合磷脂脂质体，并与相应的单一磷脂脂质体比较药剂学性质。

OBJECTIVE: To prepare cholesterol succinyl chitosan anchored liposomes, and to investigate the effect of CHCS anchored liposomes on the release property in vitro of loading drugs taking epirubicin as a model drug.

目的：通过"锚定"的方式制备胆甾醇琥珀酰基壳聚糖锚定脂质体，并以表阿霉素作为模型药物，考察其对包载药物体外释放性质的影响。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。