查询词典 liposome

The objective of this study was to develop a good and stable taxol liposome and taxol modified liposome that have heart targeted effect.

本研究的主要目的是研究稳定性良好的紫杉醇脂质体和阿替洛尔修饰的紫杉醇脂质体。

To observe effect of receptor ligand on subcelluar distribution of liposome was found that alprenolol liposomes was increased in mitochondria and sarcolemma,especially in nuclei(8 fold increased), as compared with blank liposome.

观察受体配基对脂质体在心肌亚细胞器中分布的影响，结果发现，烯丙洛尔掺入脂质体，使脂质体在细胞核、线粒体和肌膜的分布增加，尤其在细胞核增加最明显，较空白脂质体增多了8倍。

HRP was coupled with the fluorochrome FITC and encapsulated with liposome . pEGFP-N1 plasmid (expressing green fluorescent protein) with encapsulation in commercially available liposome was prepared. The eyes were enucleated 1, 4 and 8 weeks after zonule rupture and anterior segments comprising lenses were incubated in medium containing one of these components. Cryo-sections were made and translocation of fluorescent macromolecule from the medium into the lens and green fluorescent protein expression in the epithelium were observed by fluorescent microscopy.

制备FITC标记的HRP脂质体；制备pEGFP-N1质粒（表达绿色荧光蛋白的质粒），并用脂质体包裹；豚鼠悬韧带部分离断后1周、4周、8周取含晶状体的眼前段标本分别在含有FITC-HRP复合物、pEGFP-N1质粒的培养基中孵育，冰冻切片，荧光显微镜观察FITC-HRP复合物进入晶状体和pEGFP-N1质粒在晶状体内表达的情况，比较悬韧带离断侧与非离断侧的差异。3。

Objective: To investigate the prepation of the liposome carried with vincristine sulfate and mitoxantrone chlorhydric acid and to evaluate the quality of the liposome.

中文摘要：目的：制备同时包结硫酸长春新碱、盐酸米托蒽醌的复方脂质体并考察其制剂学性质。

The research of liposome mainly focuses on the release of the drug controllably and the study of liposome when it is used as gene carrier.

目前对脂质体的研究主要集中在制剂的可控释放以及其作为基因载体时的研究。

We used phospholipid, Epikuron 200, and cholesterol as material to prepare liposome formulation, and discuss the effect of liposome formulation which contain phospholipid and cholesterol or the mix of ionic surfactants such as stearylamine, dicetyl phosphate and nonionic surfactant such as Tween 80. For the three group that physical properties of drug entrapment efficiency, particle size and stability of formulation on day 0, 14, 21 and 30 were respectively compared, and further, we were sieve out optimization of formulation.

我们利用Epikuron 200之磷脂质，以及胆固醇作为制备微脂粒处方之材料，并探讨处方不加或分别加入表面修饰剂stearylaminem与dicetyl phosphate以及非离子界面活性剂Tween 80对处方之影响，且比较此三组微脂粒的物理性质，包含包埋率、粒径大小以及处方在第0、14、21、30天之安定性的变化，进一步筛选出理想之处方。

Viral vector mainly contain adenovirus, retrovirus,adeno-associated virus and so on, but it has potential danger of safety; it isrepeled by immune system when it is injected to organism for a greatimmunogenicity. An injection with adenovirus vector with highconcentration, it leads to serious inflammatory reaction of liver. Viralvector such as liposome and polycation are commonly used lately. But,liposome and polycation have low specificness and targetness of genetransfer tissue, have lower transfection efficiency and short period ofgene expression, for they can be phagocytized by endothelial system.

许多的载体，病毒载体和非病毒载体以前已广泛应用，病毒载体主要包括腺病毒，逆转录病毒，腺相关病毒等；但病毒载体在安全性方面存在潜在的危险；免疫原性比较强，注射到机体后很快会被机体的免疫系统排斥，当静脉注射高浓度的腺病毒载体会使肝脏发生严重的炎症反应；非病毒载体目前常用的有脂质体及多聚阳离子聚合物；但脂质体和阳离子聚合物介导基因转移缺乏组织的特异性和靶向性，转染效率较低且易被网状内皮系统吞噬，基因表达时间短；因此研制新型的非病毒载体已成为研究的热点，纳米颗粒具有小尺寸效应，表面效应，随着颗粒直径变小，比表面积将会显著增大，故具有很高的化学活性，因而纳米成为了最有应用前景的非病毒载体。

Therefore, we used physical mechanism trigger drug release from liposome. In this study, the small unilamellar vesicles liposome were encapsulated hydrophilic marker drug 5(6)-Carboxylfluorescein and prepared by the thin layer hydration and extrusion methods. Liposomal suspension were exposed to the magnetic field.

因此希望以物理方式驱动微脂粒药物释放，本研究以薄膜水合法与挤压法制造单层微胞微脂粒包覆水溶性药物5(6)-Carboxylfluorescein的萤光指示剂经由磁场照射，以粒径仪、界面电位仪与萤光仪发现微脂粒经由磁场照射后使得微脂粒形体改变，粒径和带电性明显变化、萤光药物释放量增加。

After the RT-PCR detection of the total RNA from heart tissue, we found that the CD59 gene and MCP gene were expressed. 4. The CD59 gene and MCP gene were mixed with liposome, then used to produce transgenic swine by 3 methods. Firstly, the gene/ liposome complex was directly injected into male swine's testis. The transfected males copulated with 8 females each 44 days later.

其中睾丸注射法处理公猪1头，44d后配母猪8头，7头受孕，产仔73头，结果检测到PCR阳性猪3头(阳性率4.3%)；输精管注射法处理公猪3头，8d后配母猪3头，0头受孕；外源基因/精子共孵育法处理公猪4头，处理母猪4头，1头受孕，产仔11头，结果检测到PCR阳性猪1头(阳性率9%)。

The CD59 gene and MCP gene were mixed with liposome, then used to produce transgenic mice by 3 methods. Firstly, the gene/ liposome complex was directly injected into 5 male mice's testis. The 5 transfected males copulated with 25 females each 7 days later.

将分别含CD59基因和MCP基因的表达载体与脂质体混合制成基因-脂质体复合物，分别采用睾丸注射、输精管注射和精子/基因-脂质体复合物共孵育三种方法生产转双基因小鼠。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。