查询词典 liposome

The team developed a siRNA product that specifically blocks the transcription of the gene that codes for IL-8, thereby blocking production of this protein, and encases it in a liposome delivery system. In mouse studies, this product showed activity against 2 ovarian cancer cell lines, both when used alone and when used in combination with docetaxel. In addition, the mouse studies revealed that the product was decreasing tumor growth through anti-angiogenic mechanisms — the treated tumors showed a lower microvessel density, the researchers report. This product was "highly effective in our preclinical studies and may merit clinical development," they write. However, they also caution that the cell lines used to create the mouse models might not accurately reflect the heterogeneity seen in human tumors.

该团队发展一种siRNA产品，特别阻断IL-8的基因转译密码，因此阻断此一蛋白质之产生，且将它包入一个微脂粒传递系统；在老鼠研究中，不论单独使用或者和docetaxel并用，此产品显示对两种卵巢癌细胞线有活性；此外，老鼠研究发现此产品可透过抗血管新生机转减少肿瘤生长—报告指出，治疗的肿瘤显示较少的微血管密度，此产品在我们的临床前研究中相当有效，值得临床发展；不过，他们也表示，所用的老鼠研究中的细胞线可能无法精准反应人类肿瘤的异质性。

The team developed a siRNA product that specifically blocks the transcription of the gene that codes for IL-8, thereby blocking production of this protein, and encases it in a liposome delivery system. In mouse studies, this product showed activity against 2 ovarian cancer cell lines, both when used alone and when used in combination with docetaxel. In addition, the mouse studies revealed that the product was decreasing tumor growth through anti-angiogenic mechanisms — the treated tumors showed a lower microvessel density, the researchers report. This product was \"highly effective in our preclinical studies and may merit clinical development,\" they write. However, they also caution that the cell lines used to create the mouse models might not accurately reflect the heterogeneity seen in human tumors.

该团队发展一种siRNA產品，特别阻断IL-8的基因转译密码，因此阻断此一蛋白质之產生，且将它包入一个微脂粒传递系统；在老鼠研究中，不论单独使用或者和docetaxel併用，此產品显示对两种卵巢癌细胞线有活性；此外，老鼠研究发现此產品可透过抗血管新生机转减少肿瘤生长—报告指出，治疗的肿瘤显示较少的微血管密度，此產品在我们的临床前研究中相当有效，值得临床发展；不过，他们也表示，所用的老鼠研究中的细胞线可能无法精準反应人类肿瘤的异质性。

Objective To evaluate effect of hemagglutinating virus of Japan -liposome mediated tissue factor pathway inhibitor gene transfer on neointimal hyperplasia of endothelium denuded carotid artery of rat.

目的 探讨日本凝血病毒-脂质体介导的组织因子途径抑制剂基因转移对大鼠颈总动脉内皮剥脱术后新生内膜增生的抑制作用。

So in order to get recombinant NT-3, the rat NT-3cDNA was reconstructed in a mammalian expression vector and transfected into incasing CHO cells by liposome-mediated method. The clones of the cells transferred with rNT-3cDNA were selected by G418. The Chinese hamster ovary cell line stably producing recombinant rat NT-3 was established.

因此，为了获得基因重组NT-3，研究其生物效应，本文成功构建了重组大鼠NT-3基因真核生物细胞稳定表达载体，并利用脂质体介导，转染进CHO细胞；经G418筛选，建立了中国仓鼠卵巢细胞系，稳定表达重组大鼠NT-3。

Thirdly, we incubated the gene/ liposome complex with sperm, then artificially inseminated, and 53 of 357 embryos had fluorescence.

PCR检测得到的胚胎，发现表达绿色荧光蛋白的胚胎其PCR反应阳性率为100%，说明外源基因在胚胎发育早期可以表达。

Therefore, it is possible that liposome drug delivery system raised the DXR's inhibition effect of metastasizing of carcinoma.

因此，脂质体形成了DXR的体内贮库，延缓了DXR在中央室的消除以及从中央室向周边室的分布，延长了DXR在血液循环系统中的运行时间。

Liposome properties and biological behaviors can be controlled by surface modification. Attachments of hydrophilic polymers, such as poly, enable them to have a prolonged circulation time without being opsonized and recognized by mononuclear phagocytic system.

通过表面修饰可以改变脂质体的性质和生物学行为：在脂质体表面修饰亲水性高分子可以阻碍血浆成分的调理作用，减少脂质体被网状内皮系统识别和摄取，使脂质体具有长循环的特点；在脂质体表面修饰特异性的配基，能使脂质体具有主动靶向的特性。

Besides, the cuticles that resist external invasions can be ridded of with fruit acids so that DNA vaccine wrapped with liposome can pass the skin.

而肤表面的角质层，会将很多外来的东西阻挡在外，因此只要先透过果酸把角质层去除，被微脂体包覆的DNA疫苗就可经皮传输进入体内。

At last,the optimized formula composition and technique of preparation were obtained by orthogonal design,and long-circulating praziquantel liposome was prepared.

优化后的脂质体其包封率在72%以上，体积粒径范围200 nm~300 nm，电镜结果显示，脂质体外观圆整而均匀。

At last,the optimized formula composition and technique of preparation were obtained by orthogonal design,and long-circulating praziquantel liposome was prepared.

在建立吡喹酮含量测定方法的基础上，通过葡聚糖凝胶柱色谱法、显微镜法、激光散射法等定性及定量方法考察脂质体的包封率、微粒外观、粒径及其分布等指标。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。