查询词典 liposome

To adopt antiphase evaporation transonic method and high speed agitation method to prepare Semustine Magnetic Liposome, to carry out the exosyndrome with TEM, image analysis system and energy spectrometer, to test the envelopment rate of semustine in the liposome.

采用反相蒸发超声法加高速搅拌制备纳米司莫司汀磁性脂质体，用透射电镜、图像分析系统和能谱仪对其进行表征，HPLC法检验脂质体中司莫司汀的包封率。

The Fe3O4 magnetic nanoparticle is a good carrier to prepare medical magnetic liposome. The adoption of antiphase evaporation transonic method and high speed agitation method can prepare nanometer Fe3O4 magnetic liposome.

Fe3O4纳米粒子是制备医用磁性脂质体的良好载体，采用反相蒸发超声法加高速搅拌可制备纳米级Fe3O4磁性脂质体。

Brucine and its liposome could inhibit the growth of transplanted solid tumor and the inhibitory effect of its liposome is much stronger than that of brucine.

马钱子碱及其脂质体有显著的抑制荷瘤小鼠肿瘤生长作用，马钱子碱脂质体抗肿瘤作用明显强于马钱子碱。

In a short time,the inhibition of Liposome didn\'t increase accordingly with the increasing of dose.

Liposome对细胞的抑制作用也随着浓度的增加更明显，但作用时间较短时，浓度的增加并不能同步增加对细胞生长的抑制。

Recombinant plasmid pSVH 7 DNA of avian influenza virus H7 subtype heamagglutinin gene was encapsulated with DC-chol/DOPE liposomes and PC/chol/SA liposomes separately. Two-week old SPF chickens were intramuscularly inoculated with 50 μ g/0.2ml of the liposome entrapped PSVH 7 DNA. Four-weeks later, each chicken was challenged with 0.1ml 〓 AIV . One week after the challenge, the secretion of the cloacas was collected and transfected to chicken embryos to isolate the virus. The virus was isolated from 6/6 of the control group, 1/6 of the naked DNA group, 1/6 of the PC/chol/SA entrapped DNA group and 0/6 of the DC-chol/DOPE liposome entrapped group. The HI antibody titers (log2) of the four groups were 6. 83±0.98, 7. 0±1. 26, 7. 83±1. 17 and 8. 00±0.89 respectively 1-week after challenge, and 8. 5±0.55, 8. 17±0.82, 8. 68±0.45 and 9. 33±0.54 respectively 2-week after challenge. The results showed that inoculation of liposome entrapped DNA significantly enhanced resistance to virosis in animals.

将含禽流感病毒H7亚型血凝素基因的重组质粒pSVH7用DC-chol阳离子脂质体和胆固醇／卵磷脂／十八胺脂质体包裹，免疫2周龄SPF鸡，4周后用同型禽流感病毒进行人工感染，1周后采集泄殖腔分泌物分离病毒，结果未免疫组6／6分离到病毒，裸质粒DNA免疫组1／6分离到病毒胆固醇／卵磷脂／十八胺脂质体包裹DNA免疫组1／6分离到病毒，DC-chol脂质体DNA免疫组没有分离到病毒（0／6）：人工感染后1周各组的HI抗体（Log2）分别为6.38±0.98，7.00±1.26，7.83±1.17，8.00±0.89，2周后为8.50±0.55，8.67±0.82，8.68±0.45，9.33±0.52，脂质体包裹组在同期均高于未免疫组和裸DNA免疫组，表明脂质体包裹质粒DNA免疫动物后，能增加动物对病毒感染的抵抗力和反应能力。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

Methods BALB/c nude mice were subcutaneously transplanted with SCG-7901 tumor cells, then the mice were randomly divided into antisense oligonucleotide group, sense oligonucleotide group and the control group. The HIF-1α ASOND complexed with cationic liposome, HIF-1α SOND complexed with cationic liposome and liposome were injected intra-tumorally in the above groups, respectively.

用人胃癌细胞株SCG-7901建立胃癌裸鼠皮下移植瘤模型，将荷瘤裸鼠随机分为反义寡核苷酸组、正义寡核苷酸组和对照组，瘤体内分别注射阳离子脂质体包裹的HIF-1αASOND、HIF-1αSOND和空白阳离子脂质体。

In our experiments, two different kinds of liposome were used as models, one is negatively charged POPG liposome, and the other is zwitterionic POPC liposome.

我们用两种不同电性的脂质体作为模型，一种是带负电荷的POPG脂质体，另一种是电中性的POPC脂质体，希望考察静电作用力在HIV-1融合肽进攻脂膜的过程中所起的作用。

Almost all CF was released from Dansyl-PE by CTX-IX that osmosed the Dansyl-PE liposome like detergent; CF releases from PE or PS liposome induced by CTX-IX were related with both of CTX-IX and phospholipid concentrations, this indicated that the phase seperation should be a reasonable mechanism for CF permeability of PS or PE liposome in the presence of CTX-IX rather than CTX-IX channel formation on the membrane. CTX-IX influence of CF release of PC liposome was very slight. CF release from Dansyl-PE、PE or PE liposome in response to CTX-IX could be inhibited by Ca〓.

CTX-IX对靶脂如此种种强烈的作用，使得它引起含Dansyl-PE脂质体CF的泄漏犹如击污剂那样强烈；引起含PS或PE脂质体CF渗透的增加为一个与CTX-IX及磷脂浓度有关的二级反应过程，这种动力学特征提示渗透性增加的机制可能是CTX-IX在脂膜上产生的脂质分子相分离，而不是CTX-IX脂膜上形成通道；CTX-IX对PC脂质体渗透性几乎没有影响，而对上述脂质体渗透性增加作用均可被Ca〓所抑制。

Results Brucine and its liposome had significant inhibiting effect on transplanted tumor growth in mice. Inhibitory rates of brucine on Heps were 35.05% [1.61mg/], 43.70% [3.23mg/], and 46.09% [6.46mg/], while of its liposome on Reps was 45.41% 1.61mg/1 and 58.19% [3.23 mg/, respectively. The inhibitory rate of brucine on S180 was 37.59% [1.61 mg/], 36.13% 3.23mg/, and 38.87% [6.46 mg/, while of its liposome on S180 was 53.00% [1.61mg/] and 48.37% [3.23mg/], respectively. However, both of them had no distinct effect on prolonging the life of mice with transplanted tumor.

结果 马钱子碱及其脂质体能有效抑制实体瘤模型荷瘤小鼠体内肿瘤生长，1.61、3.23、6.46mg/马钱子碱对Heps小鼠的抑瘤率分别为35.05%、43.70%和46.09%，而1.61、3.23mg/马钱子碱脂质体的抑瘤率分别为45.41%和58.19%；1.61%、3.23、6.46mg/马钱子碱对S180小鼠的抑瘤率分别为37.59%、36.13%和35.57%，而1.61和3.23mg/马钱子碱脂质体的抑瘤率分别为53.00%和48.37%，明显高于马钱子碱；但两者对腹水瘤模型荷瘤小鼠的生存时间均无延长作用。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。